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Table 2 Patient characteristics and pathological findings of four women with contralateral SLN metastasis following bilateral IFL

From: The potential risk of contralateral non-sentinel groin node metastasis in women with early primary vulvar cancer following unilateral sentinel node metastasis: a single center evaluation in University Hospital of Düsseldorf

  Initial diagnosis Smoker Pathological results and disease chronology
1 2005
54 years’ old
TZ = 2 cm
TI = 5 mm
BMI = 19.1
Yes SLNB showed left-sided metastasis 2 mm. IFL showed right-sided metastasis 2 mm. Subsequently, she received radiotherapy of both groins
2011: squamous cell laryngeal cancer (negative p16)
2014: squamous cell pulmonary cancer (negative p16)
2019: still alive with no signs of recurrence
2 2015
56 years’ old
TZ = 3,5 cm
TI = 9 mm
BMI = 29.8
No SLNB showed right-sided metastasis 9 mm with infiltration of blood vessel (V1)
IFL showed left-sided metastasis 7 mm with extra capsular tumor cells
Pelvic lymphadenectomy showed no metastasis. Subsequently, she received bilateral radiotherapy of her inguinal regions
2019: still alive with no signs of recurrence
3 6/2016
67 years’ old
TZ = 2,5 cm
TI = 8 mm
BMI = 28.8
Yes 2014: kidney transplantation (tacrolimus and mycophenolic acid)
6/2016: SLNB showed right-sided metastasis 3 mm. Complete IFL showed left-sided metastasis 3 mm
Tacrolimus was changed into Everolimus. The patient received bilateral radiotherapy of her inguinal regions
8/2017: passed away due to lung metastasis of vulvar cancer
4 2018
51 years’ old
TZ = 1,6 cm
TI = 2,3 mm
BMI = 25.6
Yes SLNB showed right-sided metastasis 3 mm. IFL showed left-sided metastasis 8 mm. Pelvic lymphadenectomy showed no metastasis. Subsequently, she received bilateral radiotherapy of her inguinal regions
2019: recurrent vulvar cancer after 18 months (metastasis in fat tissue at mons pubis paramedian on the left side with infiltration into venous blood vessel). Surgery followed by radio chemotherapy was performed until December 2019
  1. TZ tumor size, TI tumor infiltration, BMI body mass index