Skip to main content

Table 3 Risk factors for local recurrence by Cox proportional hazard regression analysis

From: Risk factors of local recurrence following implant-based breast reconstruction in breast cancer patients

Factor Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Age    0.069    
 ≤ 40 2.90 0.92–9.15     
 > 40 1.00      
MRI findings    0.520    
Segmental lesion 1.00      
Isolated mass 1.96 0.25–15.37     
Histology    0.423    
DCIS/LCIS 1.00      
IDC/ILC 0.56 0.13–2.34     
Tumor size    0.507    
Is 1.00      
1 0.66 0.15–2.95     
2/3 0.62 0.34–6.13     
Nodal status    0.294    
 −  1.00      
 +  1.90 0.57–6.32     
Stage    0.849    
0 1.00      
I 0.80 0.18–3.60     
II/III 1.18 0.28–4.97     
ER    0.482    
 +  1.00      
 −  1.61 0.42–6.04     
PgR    0.965    
 +  1.00 0.28–3.44     
 −  0.97      
HER2    0.776    
 +  1.00      
 −  0.82 0.21–3.19     
Subtype    0.526    
Luminal A-like 1.00      
Luminal B-like HER2 negative 2.24 0.55–9.06     
Luminal B-like HER2 positive/HER2 1.56 0.38–6.48     
EIC    0.927    
 +  0.94 0.23–3.77     
 −  1.00      
Lymphatic vessel invasion    0.005    0.017
 +  6.60 1.78–24.47   6.63 1.40–31.36  
 −  1.00      
Nuclear grade    0.518    
Low/intermediate/high grade DCIS 1.00      
1 0.75 0.12–4.60     
2/3 1.64 0.33–8.16     
Operation    0.905    
TM/SSM 1.00      
NSM 1.43 0.17–11.88     
ASM 1.44 0.18–11.45     
Surgical margin (lateral)    0.568    
 + , < 2 mm 1.82 0.23–14.24     
 −  1.00      
Surgical margin (vertical)    0.018    0.031
 + , < 2 mm 10.58 1.32–84.64   9.72 1.23–77.13  
 −  1.00    1.00   
Adjuvant hormonal therapy    0.402    
 +  0.61 0.19–1.94     
 −  1.00      
Any chemotherapy ± Trastuzumab    0.650    
 +  1.31 0.41–4.16     
 −  1.00      
  1. The p-values less than 0.05 are underlined
  2. HR, Hazard ratio; CI, Confidence Interval; MRI, Magnetic Resonance Imaging; DCIS, Ductal carcinoma in situ; LCIS, Lobular carcinoma in situ; IDC, Invasive ductal carcinoma; ILC, Invasive lobular carcinoma; EIC, Extensive intraductal component; TM: Total mastectomy; SSM: Skin-sparing mastectomy; NSM: Nipple-sparing mastectomy; ASM: Areola-sparing mastectomy; PMRT: Post-Mastectomy Radiotherapy