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Table 3 Correlation between pathological types and HPV-DNA load

From: Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study

  CIN I CIN II
Univariable OR (95% CI) P Multivariable OR (95% CI) P Univariable OR (95% CI) P Multivariable OR (95% CI) P
Age < 30 years Ref   Ref   Ref   Ref  
30–40 years 0.488 (0.187, 1.274) 0.143 0.51 (0.193, 1.345) 0.173 1.057 (0.343, 3.256) 0.923 1.173 (0.371, 3.71) 0.786
≥ 40 years 0.966 (0.432, 2.158) 0.932 0.931 (0.412, 2.107) 0.864 0.523 (0.16, 1.71) 0.283 0.483 (0.144, 1.62) 0.238
Low load Ref   Ref   Ref   Ref  
Moderate load 1.803 (0.879, 3.698) 0.108 1.815 (0.882, 3.737) 0.106 1.822 (0.664, 4.998) 0.244 1.804 (0.654, 4.976) 0.254
High load 3.905 (1.285, 11.869) 0.016 3.568 (1.164, 10.941) 0.026 5.857 (1.561, 21.973) 0.009 6.939 (1.793, 26.852) 0.005
  CIN III Cervical cancer
Univariable OR (95% CI) P Multivariable OR (95% CI) P Univariable OR (95% CI) P Multivariable OR (95% CI) P
Age < 30 years Ref   Ref   Ref   Ref  
30–40 years 1.776 (0.572, 5.514) 0.321 1.92 (0.602, 6.124) 0.271 1.902 (0.188, 19.279) 0.586 2.122 (0.206, 21.864) 0.527
≥ 40 years 2.421 (0.838, 6.99) 0.102 2.275 (0.768, 6.734) 0.138 7.172 (0.903, 56.986) 0.062 6.599 (0.818, 53.229) 0.076
Low load Ref   Ref   Ref   Ref  
Moderate load 2.847 (1.324, 6.121) 0.007 2.852 (1.322, 6.152) 0.008 2.278 (0.744, 6.971) 0.149 2.308 (0.744, 7.159) 0.148
High load 7.321 (2.426, 22.093) < 0.001 7.052 (2.304, 21.586) 0.001 10.041 (2.64, 38.19) 0.001 8.266 (2.12, 32.233) 0.002
  1. CIN Cervical intraepithelial neoplasia, OR odds ratio, CI confidence interval