From: Effects of early estradiol valerate administration on bone turnover markers in surgically induced menopausal women
Bone turnover markers
Hormone treatment group (n = 21)
No treatment group (n = 20)
p-value
CTX levels (ng/ml)
0.21 (0.14–0.34)
0.47 (0.28–0.65)
 < 0.001
P1NP levels (ng/ml)
42.41 (31.42–63.61)
63.63 (54.98–80.45)
0.004