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Table 2 Multivariable hazard ratios (HR) and 95% confidence intervals (CI) of incident T2DM by number of parity until phase VI (2015–2018): Tehran Lipid and Glucose Study

From: The association of parity/live birth number with incident type 2 diabetes among women: over 15 years of follow-up in The Tehran Lipid and Glucose Study

 

E/N

Model 1

Model 2

Model 3

Model 4

Model 5

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Parity (continuous variable)

           

Per each additional

557/2552

1.10 (1.05–1.16)

< 0.001

1.10 (1.04–1.15)

< 0.001

1.09 (1.04–1.15)

0.001

1.05 (1.00–1.11)

0.075

1.04 (0.99–1.10)

0.108

Number of parity

           

1

19/180

1

 

1

 

1

 

1

 

1

 

2

99/614

1.48 (0.90–2.41)

0.121

1.48 (0.91–2.43)

0.116

1.48 (0.90–2.42)

0.119

1.41 (0.86–2.31)

0.172

1.39 (0.85–2.27)

0.193

3

128/640

1.74 (1.07–2.83)

0.025

1.75 (1.07–2.86)

0.025

1.73 (1.06–2.83)

0.028

1.54 (0.94–2.52)

0.084

1.50 (0.92–2.45)

0.107

≥ 4

311/1118

2.28 (1.40–3.70)

0.001

2.27 (1.39–3.72)

0.001

2.23 (1.36–3.65)

0.001

1.72 (1.05–2.83)

0.031

1.64 (1.00–2.70)

0.051

P value for trend

  

< 0.001

 

< 0.001

 

< 0.001

 

0.027

 

0.055

  1. Model 1: Adjusted for age. Model 2: Adjusted for age, education level, low physical activity, family history of diabetes, systolic and diastolic blood pressure, and anti-hypertensive medications usage. Model 3: Model 2 + further adjusted for history of macrosomia, preeclampsia, and oral contraceptive pill (OCP) usage. Model 4: Model 3 + further adjusted for body mass index and waist circumference. Model 5: Model 4 + further adjusted for triglyceride/ high-density lipoprotein cholesterol. T2DM: type 2 diabetes mellitus; E: event; N: number