The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Table 3 Investigation of the relationship between the risk of polymorphisms related to Primary Ovarian Insufficiency and dyslipidemia factors in the study population in a non-adjusted model

Polymorphisms Lipid profile abnormalities	POI cases				Controls
Polymorphisms Lipid profile abnormalities	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
rs16991615	GA/AA		GG/AA		GA/AA		GG/AA
High LDL (mg/dl)	0.65 (0.24, 1.74)	0.39	1.15 (0.45,2.97)	0.77	0.65 (0.23, 1.84)	0.42	0.46 (0.16,1.30)	0.14
High Triglyceride (mg/dl)	0.51 (0.17, 1.50)	0.22	0.87 (0.32, 2.35)	0.79	1.93 (0.51, 7.32)	0.33	2.41 (0.64, 9.02)	0.19
Low HDL (mg/dl)	1.43 (0.52, 3.89)	0.48	1.08 (0.41, 2.80)	0.87	0.96 (0.32, 2.85)	0.94	0.88 (0.30, 2.59)	0.82
High total cholesterol (mg/dl)	0.36 (0.12, 1.02)	0.054	0.89 (0.32, 2.51)	0.83	0.64 (0.23, 1.83)	0.41	0.63 (0.22, 1.78)	0.39

rs244715	AG/GG		AA/GG		AG/GG		AA/GG
High LDL (mg/dl)	2.06 (0.57, 7.47)	0.27	1.03 (0.29, 3.69)	0.95	1.22 (0.13, 11.47)	0.85	3.16 (0.35, 28.01)	0.30
High Triglyceride (mg/dl)	0.42 (0.11, 1.54)	0.19	0.38 (0.10, 1.38)	0.14	1.12 (0.19, 6.66)	0.89	0.66 (0.11, 3.83)	0.64
Low HDL (mg/dl)	0.61 (0.16, 2.34)	0.48	0.78 (0.21, 2.93)	0.72	0.38 (0.04, 3.47)	0.39	0.35 (0.04, 3.11)	0.34
High total cholesterol (mg/dl)	1.86 (0.52, 6.94)	0.35	0.76 (0.21, 2.72)	0.68	0.71 (0.12, 4.26)	0.71	1.31 (0.23, 7.47)	0.75

rs451417	CA/AA		CC/AA		CA/AA		CC/AA
High LDL (mg/dl)	1.23 (0.47, 3.26)	0.66	1.80 (0.71, 4.52)	0.21	0.53 (0.18, 1.55)	0.25	1.19 (0.43, 3.28)	0.73
High Triglyceride (mg/dl)	0.69 (0.25, 1.91)	0.48	0.55 (0.21, 1.48)	0.24	1.96 (0.59, 6.48)	0.27	1.52 (0.46, 5.02)	0.48
Low HDL (mg/dl)	1.27 (0.47, 3.42)	0.62	0.94 (0.37, 2.35)	0.89	0.82 (0.29, 2.30)	0.71	1.19 (0.42, 3.33)	0.73
High total cholesterol (mg/dl)	0.88 (0.33, 2.35)	0.80	1.07 (0.42, 2.75)	0.87	0.57 (0.20, 1.59)	0.28	1.01 (0.37, 2.72)	0.98

rs1046089	GA/AA		GG/AA		GA/AA		GG/AA
High LDL (mg/dl)	2.58 (0.62, 10.62)	0.18	3.50 (0.79, 15.34)	0.09	4.82 (1.05, 21.98)	0.04	6.83 (1.48, 31.46)	0.01
High Triglyceride (mg/dl)	0.46 (0.12, 1.69)	0.24	0.57 (0.14, 2.27)	0.43	1.04 (0.38, 2.83)	0.92	0.77 (0.27, 2.18)	0.63
Low HDL (mg/dl)	1.68 (0.46, 6.10)	0.42	2.21 (0.56, 8.67)	0.25	1.76 (0.70, 4.44)	0.22	3.21 (1.20, 8.53)	0.02
High total cholesterol (mg/dl)	1.92 (0.53, 6.95)	0.32	2.21 (0.56, 8.67)	0.25	2.33 (0.79, 6.85)	0.12	1.83 (0.60, 5.55)	0.28

rs7246479	TA/AA		TT/AA		TA/AA		TT/AA
High LDL (mg/dl)	0.46 (0.13, 1.61)	0.22	1.36 (0.35, 5.24)	0.64	2.86 (0.33, 24.54)	0.33	3.93 (0.46, 33.38)	0.21
High Triglyceride (mg/dl)	1.04 (0.25, 4.29)	0.95	2.25 (0.51, 9.76)	0.27	0.34 (0.07, 1.49)	0.15	0.43 (0.10, 1.87)	0.26
Low HDL (mg/dl)
High total cholesterol (mg/dl)	0.53 (0.14, 1.93)	0.34	1.68 (0.40, 7.09)	0.47	1.44 (0.27, 7.63)	0.66	1.85 (0.35, 9.71)	0.46

rs4806660	TC/CC		TT/CC		TC/CC		TT/CC
High LDL (mg/dl)	2.72 (0.72, 10.21)	0.13	1.63 (0.43, 6.13)	0.47	–	–	–	–
High Triglyceride (mg/dl)	1.87 (0.45, 7.76)	0.38	0.97 (0.22, 4.18)	0.97	0.61 (0.12, 2.96)	0.54	0.45 (0.09, 2.19)	0.32
Low HDL (mg/dl)	7.40 (1.75, 31.16)	0.01	3.68 (0.88, 15.27)	0.07	073 (0.13, 4.01)	0.72	0.73 (0.13, 4.02)	0.72
High Total Cholesterol (mg/dl)	2.14 (0.57, 7.92)	0.25	0.63 (0.17, 2.26)	0.48	–	–	–	–

rs10183486	CT/TT		CC/TT		CT/TT		CC/TT
High LDL (mg/dl)	0.82 (0.23, 2.94)	0.76	2.71 (0.74, 9.92)	0.13	1.95 (0.38, 10.02)	0.42	1.43 (0.27, 7.33)	0.66
High Triglyceride (mg/dl)	1.75 (0.34, 8.98)	0.50	3.39 (0.66, 17.25)	0.14	0.33 (0.08, 1.37)	0.12	0.65 (0.16, 2.61)	0.55
Low HDL (mg/dl)	0.62 (0.16, 2.32)	0.48	0.80 (0.21, 3.06)	0.75	0.23 (0.02, 1.98)	0.18	0.20 (0.02, 1.72)	0.14
High Total Cholesterol (mg/dl)	1.50 (0.42, 5.34)	0.52	4.58 (1.21, 17.35)	0.02	1.30 (0.30, 5.60)	0.72	0.90 (0.21, 3.87)	0.89

rs2303369	CT/TT		CC/TT		CT/TT		CC/TT
High LDL (mg/dl)	2.41 (0.82, 7.11)	0.11	1.34 (0.43, 4.10)	0.61	6.77 (0.85, 53.83)	0.07	9.06 (1.13, 72.25)	0.03
High Triglyceride (mg/dl)	3.23 (0.83, 12.49)	0.08	2.20 (0.54, 8.99)	0.26	1.42 (0.42, 4.80)	0.56	1.05 (0.30, 3.64)	0.93
Low HDL (mg/dl)	6.03 (1.92, 18.94)	0.002	2.51 (0.79, 7.89)	0.11	4.94 (1.47, 16.55)	0.01	9.83 (2.82, 34.27)	< 0.001
High Total Cholesterol (mg/dl)	0.75 (0.23, 2.44)	0.64	0.30 (0.09, 1.01)	0.05	2.88 (0.76, 10.86)	0.11	2.08 (0.54, 7.98)	0.28

Binary logistic regression models were performed; POI: Primary Ovarian Insufficiency; LDL: Low-Density Lipoprotein; HDL: High-Density Lipoprotein; High LDL > 130 and Normal LDL < 130; High Triglyceride > 150 and Normal Triglyceride < 150; Low HDL < 40 (Male) or < 50 (Female) and Normal HDL > 40 (Male) or > 50 (Female), High Total Cholesterol > 200 and Normal Total Cholesterol < 200; Normal groups of all lipid profile measures were considered as references; The common genotypes of each studied variants were considered as references; Significant P-value < 0.05

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