Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative

Table 2 Association between quartiles of activity level and mortality risk in 8543 participants with breast cancer in the WHI study

# of participants		Physical activity level group				P_trend	HR (95% CI)	P_Interaction^c
# of participants		0 N = 1987	> 0–2.9 N = 892	3–8.9 N = 1958	≥ 9 N = 3706	P_trend	HR (95% CI)	P_Interaction^c
All-cause mortality^a
All	# Deaths	768	306	575	1106
All	HR (95% CI)	1.00	0.96 (0.84–1.10)	0.80 (0.72–0.90)	0.86 (0.78–0.95)	< 0.001	0.95 (0.92–0.98)
# of metabolic risk factors
0	HR (95% CI)	1.00	0.98 (0.71–1.36)	0.83 (0.65–1.07)	0.84 (0.67–1.05)	0.09	0.94 (0.88–1.01)	0.75
1–2	HR (95% CI)	1.00	0.96 (0.82–1.13)	0.76 (0.66–0.87)	0.84 (0.75–0.95)	0.001	0.94 (0.90–0.97)
3–4	HR (95% CI)	1.00	1.10 (0.73–1.66)	0.87 (0.61–1.26)	0.91 (0.65–1.28)	0.48	0.96 (0.86–1.07)
Breast cancer mortality^b
All	# Deaths	190	75	156	259
All	HR (95% CI)	1.00	1.00 (0.76–1.31)	0.92 (0.74–1.15)	0.85 (0.70–1.04)	0.09	0.95 (0.89–1.01)
# Of metabolic risk factors
0	HR (95% CI)	1.00	1.16 (0.64–2.09)	0.85 (0.54–1.34)	0.92 (0.62–1.37)	0.54	0.96 (0.85–1.09)	0.46
1–2	HR (95% CI)	1.00	0.86 (0.61–1.20)	0.85 (0.65–1.11)	0.77 (0.60–0.99)	0.04	0.92 (0.85–1.00)
3–4	HR (95% CI)	1.00	2.71 (0.85–8.64)	0.82 (0.28–2.38)	1.18 (0.45–3.11)	0.87	0.97 (0.72–1.32)

Median follow-up since enrollment was 19 years, median follow-up since breast cancer diagnosis was 9.5 years
^aThe all cause multivariate model adjusts for age group, race/ethnicity alcohol intake, smoking status, BMI kg/m², # of metabolic risk factors, hormone receptor status, grade, HER2/NEU number of examined lymph nodes, number of positive lymph nodes, tumor size, and stage
^bThe breast cancer multivariate model adjusts for age group, alcohol intake, # of metabolic risk factors, hormone receptor status, grade, # positive lymph nodes, tumor size, and stage
^cP_Interaction was calculated with the cross-product between physical activity level, and # of metabolic risk factors the separate multivariate Cox proportional hazards model

ISSN: 1472-6874