Fragile X premutation carrier screening in Pakistani preconception women in primary care consultation

BMC Women's Health

Table 3 Characteristics of preconception women with FMR1 PM Alleles

Characteristics	FMR1 PM CARRIERS						Total (%)
Characteristics	PM1	PM2	PM3	PM4	PM5	PM6	Total (%)
Ages in years	25	29	30	32	35	37
CGG repeats’ number	61	72	59	71	64	58
Primary ovarian insufficiency symptoms
Irregular menstruation	+	+	_	+	+	+	83.3
Skipped menstruation	_	+	+	_	_	_	33
Subfertility	_	_	_	_	_	+	16.6
Hot splashes and night sweats	_	_	+	+	+	+	66
Low AMH level	+	+	+	+	+	+	100
High FSH level	+	+	+	+	+	+	100
Difficulty getting pregnant	_	_	_	+	_	_	16.6
Obstetric and perinatal difficulties
Antepartum hemorrhage	_	+	_	_	+	_	33
Obstructed labor	_	_	_	_	+	_	16.6
Pre-eclampsia	_	_	+	_	_	_	16.6
Hypoestrogenism conditions
Lower bone mineral density	+	_	_	_	+	_	33
Early onset osteoporosis	+	+	+	+	+	_	83.3
Bone fractures	_	+	_	+	_	_	33
Postpartum depression	+	_	+	+	+	+	83.3
Medical conditions
Hypertension	+	_	+	+	+	_	66
Migraine	+	_	_	+	+	_	50
Diabetes	_	_	+	_	_	_	16.6
Obesity	+	_	_	+	_	_	33
Neuropsychiatric features
Language issues	_	+	+	_	_	+	50
Memory loss	_	+	_	_	_	+	33
Trouble performing daily activities	+	+	_	_	_	_	33
Normal IQ level	+	+	+	+	+	+	100
Difficulty in concentrating	+	+	+	_	_	+	66
Anxiety	+	+	+	_	+	+	83.3
Attention deficit disorder	+	_	_	_	+	_	33
Sleep disturbance	+	+	+	_	+	+	83.3
Aggression	+	+	+	_	+	+	83.3
Reasoning (irritability)	_	+	_	_	+	_	33
Hyperreactivity	+	+	+	_	+	_	66

ISSN: 1472-6874