Table1 Demographic and clinical characteristics in the two study groups
Characteristic | Cases (N = 180) | Controls (N = 190) | P value |
|---|---|---|---|
Age | 44.51 ± 4.40 | 49.85 ± 6.99 | 0.001 |
Parity | 1.61 ± 1.22 | 2.47 ± 1.37 | < 0.001 |
Gravidity | 1.95 ± 1.40 | 2.8 ± 1.49 | < 0.001 |
BMI | 27 ± 4.27 | 28.7 ± 4.36 | 0.001 |
Age at menarche | 13.41 ± 1.5 | 13.33 ± 1.20 | 0.57 |
Age at first pregnancy | 22.45 ± 4.94 | 21.44 ± 5.12 | 0.07 |
Menopause age | 46.15 ± 4 | 49.34 ± 4.82 | 0.002 |
OCP usage duration (year) | 1.85 ± 2.43 | 3.51 ± 4.87 | 0.002 |
Progesterone usage duration (year) | 1.41 ± 2.46 | 1.50 ± 2.45 | 0.86 |
Lactation duration | 0.001 | ||
Never | 42 (23.3%) | 13(6.8%) | |
Less than 6 months | 3 (1.7%) | 3(1.6%) | |
7–12 month | 0 (0%) | 9 (4.7%) | |
13–24 month | 63 (35%) | 73 (38.4%) | |
More than 24 month | 72 (40%) | 92 (48.4%) | |
Menopausal status | 28 (15.4%) | 58 (30.5%) | 0.001 |
Infertility | 49 (27.2%) | 17 (8.9%) | 0.001 |
Infertility treatment (n = 66) | 33 (67%) | 9 (52.9%) | 0.28 |
History of miscarriage | 50(27.8%) | 59 (31.1%) | 0.49 |
History of curettage | 20(11.1%) | 31 (16.3%) | 0.14 |
OCP usage | 114 (63.3%) | 101 (53.2%) | 0.047 |
Progesterone usage | 93 (51.7%) | 34 (17.9%) | 0.001 |
Adenomyosis | 27 (15%) | 14 (7.4%) | 0.01 |
Abdominal surgery | 116 (64%) | 108 (56.8%) | 0.13 |
Dysmenorrhea | 121 (67.2%) | 92(48.4%) | 0.001 |
Dyspareunia | 78 (43.3%) | 49 (25.8%) | 0.001 |
Pelvic pain | 111 (61.7%) | 60 (31.6%) | 0.001 |
Breast disease | 49 (27.2%) | 74 (38.9%) | 0.01 |
Type of breast disease | 0.32 | ||
Fibro adenoma (n = 48) | 1 (2.1%) | 4 (5.8%) | |
Fibrocystic disease (n = 69) | 47 (97.9%) | 65(94.2%) | |
2nd or 3rd degree family history of breast cancer | 16 (8.9%) | 33(17.4%) | 0.01 |
Oophorectomy | 0.01 | ||
Unilateral | 4 (2.2%) | 1 (0.5%) | |
Bilateral | 10 (5.6%) | 0 (0%) | |
Hysterectomy | 16 (8.9) | 4 (2.1) | 0.004 |
Breast density | 0.001 | ||
Grade1 | 113 (62.8%) | 77 (40.5%) | |
Grade2 | 56 (31.1%) | 96 (50.5%) | |
Grade3 | 11 (6.1%) | 13 (6.8%) | |
Grade4 | 0 (0%) | 4 (2.1%) |