Molecular phenotypes and clinical characterization of familial hereditary breast cancer among half and full sisters

Table 6 Comparison of enzyme-labeled staining for ER, PR across subgroups

Variable	NHBC	HBC			Total
Variable	NHBC	CHBC	NCHBC	CHBC + NCHBC	Total
Expression of ER, n	152	18	20	38	190
(−)	44	2	2	4	48
(+)(++)(+++)	108	16	18	34	142
	X² = 0.43 P > 0.05	X² = 4.35 *P > 0.05	X² = 3.25 **P > 0.05	X² = 1.01 ^#P > 0.05
(−)(+)	66	3	7	10	76
(++)(+++)	86	15	13	28	114
	X² = 3.71 P > 0.05	X² = 3.73 *P > 0.05	X² = 0.51 **P > 0.05	X² = 0.83 ^#P > 0.05
Expression of PR, n
(−)	53	2	0	2	55
(+)(++)(+++)	99	16	20	36	135
	X² = 13.38 P < 0.005	X² = 5.93 *P > 0.05	X² = 0.23 **P > 0.05	X² = 3.7 ^#P > 0.05
(−)(+)	78	3	8	11	89
(++)(+++)	74	15	12	27	101
	X² = 6.11 P < 0.05	X² = 6.42 *P < 0.05	X² = 0.91 **P > 0.05	X² = 1.5 ^#P > 0.05

HBC hereditary breast cancer, NHBC non-hereditary breast cancer, CHBC contemporaneous hereditary breast cancer, NCHBC non-contemporaneous hereditary breast cancer
ER/PR, (−): less than 1% staining, (+): 1–30% staining, (++): 30–80% staining, (+++): more than 80% staining. P = NHBC versus HBC, *P = NHBC versus CHBC, **P = NHBC versus NCHBC, ^#P = CHBC versus NCHBC

ISSN: 1472-6874