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Table 3 Univariate and multivariate analysis for survival outcomes after recurrence

From: Reassessment of intensive surveillance practices adopted for endometrial cancer survivors

 

Univariate

Multivariate

 

Hazard ratio [95% CI]

p-value*

Hazard ratio [95% CI]

p-value*

FIGO stage

    

 I

ref

  

 II

1.736 [0.498–6.048]

0.387

  

 III

1.271 [0.678–2.385]

0.454

  

 IV

1.767 [0.845–3.691]

0.130

  

Histology

    

 Endometrioid G1/G2

ref

  

 Endometrioid G3

1.151 [0.550–2.408]

0.708

  

 Serous

0.906 [0.314–2.612]

0.885

  

 Other

1.792 [0.791–4.055]

0.162

  

Initial treatment

    

 ATH + BSO

ref

  

 ATH + BSO + PLA biopsy

0.678 [0.280–1.638]

0.388

  

 ATH + BSO + PLA

0.659 [0.327–1.329]

0.244

  

 ATH + BSO + PLA + PAN

0.596 [0.275–1.288]

0.188

  

 NAC + ATH + BSO

0.830 [0.235–2.928]

0.772

  

Time to recurrence

0.999 [0.0998–1.000]

0.008

  

Recurrence site

    

 Local

ref

ref

 Pelvic and para-aortic LN

5.836 [2.143–15.892]

0.001

5.311 [1.866–15.114]

0.002

 Peritoneal dissemination

3.088 [1.061–8.984]

0.039

2.699 [0.910–8.004]

0.073

 Distant metastasis

4.100 [1.6961–9.911]

0.002

3.876 [1.542–9.743]

0.004

Diagnosis method at recurrence

    

 Outpatient exam

ref

  

 Symptom

1.042 [0.429–2.529]

0.928

  

 Tumor marker

1.830 [0.797–4.353]

0.172

  

 Imaging analysis

1.385 [0.640–2.999]

0.409

  
  1. ATH: abdominal hysterectomy; BSO: bilateral salpingo oophorectomy; PLA: pelvic lymphadenectomy; PAN: para-aortic lymphadenectomy; NAC: neoadjuvant chemotherapy; LN: lymphnode; Out patient exam: pelvic examination, pap smear, and transvaginal ultrasoound scannning
  2. *Cox regression analysis was used