A novel Silva pattern-based model for precisely predicting recurrence in intermediate-risk cervical adenocarcinoma patients

Table 4 Four-factor model performance comparison

	Univariate Cox Analysis			Log-rank test		C index	95%CI
Models	p value	HR	95% CI	Chi-Square	p value	C index	95%CI
Sedlis Criteria	0.002	6.137	2–18.833	13.083	0.000	0.702	0.597–0.78
Four-factor Model: Tumor size, DSI, LVSI, Silva
Any 2 of 4 factors
Silva B + C, ≥ 3 cm, DSI > 2/3, > mild LVSI	0.008	16.028	2.083–123.36	12.964	0.000	0.752	0.676–0.804
Silva C, ≥ 3 cm, DSI > 2/3, > mild LVSI	0.005	6.507	1.787–23.694	10.684	0.001	0.715	0.606–0.798
Silva B + C, ≥ 3.5 cm, DSI > 2/3, > mild LVSI	0.007	16.676	2.166–128.37	13.55	0.000	0.756	0.676–0.809
Silva C, ≥ 3.5 cm, DSI > 2/3, > mild LVSI	0.005	6.507	1.787–23.694	10.684	0.001	0.715	0.606–0.798
Any 3 of 4 factors
Silva B + C, ≥ 3 cm, DSI > 2/3, > mild LVSI	0.001	7.714	2.37–25.105	16.07	0.000	0.734	0.640–0.837
Silva C, ≥ 3 cm, DSI > 2/3, > mild LVSI	< 0.001	10.792	3.31–35.19	24.262	0.000	0.761	0.670–0.862
Silva B + C, ≥ 3.5 cm, DSI > 2/3, > mild LVSI	0.001	6.321	2.059–19.402	13.621	0.000	0.706	0.595–0.799
Silva C, ≥ 3.5 cm, DSI > 2/3, > mild LVSI	< 0.001	9.445	3.065–29.101	22.696	0.000	0.735	0.626–0.830
All 4 factors
Silva B + C, ≥ 3 cm, DSI > 2/3, > mild LVSI	< 0.001	8.526	2.768–26.263	20.084	0.000	0.659	0.554–0.804
Silva C, ≥ 3 cm, DSI > 2/3, > mild LVSI	< 0.001	8.143	2.502–26.505	17.267	0.000	0.631	0.525–0.764
Silva B + C, ≥ 3.5 cm, DSI > 2/3, > mild LVSI	0.001	7.251	2.223–23.645	14.792	0.000	0.627	0.523–0.770
Silva C, ≥ 3.5 cm, DSI > 2/3, > mild LVSI	0.005	6.46	1.776–23.493	10.632	0.001	0.597	0.519–0.696

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