Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K/AKT signaling

Table 1 Anthropometric and metabolic parameters of all participants

Characteristics	Obese PCOS group (n = 11)	Non-obese PCOS group (n = 12)	Control group (n = 10)	P value
Characteristics	Obese PCOS group (n = 11)	Non-obese PCOS group (n = 12)	Control group (n = 10)	P1	P2	P3
Age (years)	30.00 ± 2.83	29.73 ± 2.53	30.33 ± 2.52	0.821	0.852	0.730
BMI (kg/m²)	28.95 ± 4.15	20.60 ± 1.65	21.63 ± 0.92	0.000**	0.000**	0.460
WHR	0.88 ± 0.07	0.78 ± 0.07	0.77 ± 0.05	0.009**	0.022*	0.801
Years of infertility (years)	3.00 ± 1.69	2.61 ± 0.93	2.25 ± 0.50	0.527	0.336	0.634
FSH (mIU/ml)	6.00 ± 1.14	6.17 ± 1.04	6.04 ± 0.77	0.719	0.935	0.828
LH (mIU/ml)	7.11 ± 3.03	8.52 ± 4.22	4.40 ± 1.48	0.390	0.143	0.028*
E2 (pg/ml)	41.31 ± 17.03	44.26 ± 15.52	46.20 ± 7.76	0.679	0.556	0.825
P (ng/ml)	0.49 ± 0.36	0.60 ± 0.28	0.69 ± 0.25	0.469	0.440	0.738
T (ng/ml)	0.59 ± 0.08	0.51 ± 0.12	0.43 ± 0.07	0.116	0.017*	0.234
PRL (pg/ml)	14.88 ± 5.79	11.26 ± 5.50	10.96 ± 4.50	0.191	0.250	0.930
FPG (mmol/L)	5.71 ± 0.25	5.10 ± 0.36	5.38 ± 0.28	0.017*	0.198	0.246
FINS (mmol/L)	18.45 ± 5.15	9.66 ± 3.17	6.74 ± 0.61	0.015*	0.003**	0.408
HOMA-IR	4.02 ± 0.95	1.84 ± 0.77	1.65 ± 0.28	0.021*	0.010*	0.778

Data are presented as mean ± SD
BMI, body mass index; WHR, waist-to-hipratio; FSH, follicular stimulating hormone; LH, luteinizing hormone; E₂, estradiol; P, progesterone; T, testosterone; PRL, prolactin; FPG, fasting plasma glucose; FINS, fasting plasma insulin; HOMA-IR, homeostasis model assessment of insulin resistance; P1, obese PCOS group versus non-obese PCOS group; P2, obese PCOS group versus control group; P3, non-obese PCOS group versus control group
*There is a significant difference between the two groups (P < 0.05); **Difference is highly significant (P < 0.01)

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