Biomarker |  | N | Mean values | Mean change compared to baseline (95% CI) | Effect size, Cohen’s d | T-statistics | p-value* | F-statistics | p-value, global |
---|---|---|---|---|---|---|---|---|---|
hs-CRP†(mg/l) | Baseline | 19 | 0.21 | – |  |  | – |  | 0.49 |
4 weeks | 18 | 0.41 | 0.18 (− 0.24 to 0.60) | 0.20 | 1.03 | 0.52 | 0.75 | ||
8 weeks | 18 | 0.36 | 0.18 (− 0.28 to 0.61) | 0.19 | 0.90 | 0.60 |  | ||
Plasma-ACTH†(ng/l) | Baseline | 18 | 2.79 | – |  |  | – |  | 0.19 |
4 weeks | 17 | 2.62 | − 0.16 (− 0.51 to 0.19) | − 0.26 | − 1.08 | 0.43 | 1.85 | ||
8 weeks | 17 | 2.86 | 0.025 (− 0.27 to 0.37) | 0.08 | 0.36 | 0.89 |  | ||
Serum-Cortisol (nmol/l) | Baseline | 19 | 361.2 | – |  |  | – |  | 0.93 |
4 weeks | 19 | 364.8 | 3.6 (− 58.9 to 66.2) | 0.03 | 0.14 | 0.98 | 0.08 | ||
8 weeks | 18 | 359.0 | − 6.4 (− 80.8 to 68.0) | − 0.05 | − 0.21 | 0.97 |  | ||
24-h-Urine-Cortisol†(nmol/24 h) | Baseline | 18 | 4.04 | – |  |  | – |  | 0.89 |
4 weeks | 18 | 4.03 | − 0.01 (− 0.47 to 0.45) | − 0.02 | − 0.06 | 1.00 | 0.12 | ||
8 weeks | 15 | 4.08 | 0.07 (− 0.38 to 0.52) | 0.12 | 0.37 | 0.90 |  |