Does full HPV genotyping perform similarly well in clinician-collected cervical samples and self-collected vaginal samples when using the CLART HPV4S assay?

Table 2 HPV genotype positivity and overall agreement within HPV genotype groups between self-samples and clinician-collected samples

HPV genotype group	Positive cases		Agreement (%)	P-value^a
HPV genotype group	Clinician-collected sample (%)	Self-sample (%)	(95% CI)	P-value^a
HPV 16/18^b	9 (4.3%)	11 (5.2%)	97.2 (93.9–99.0)	0.69
HPV 31/33/58^c	8 (3.8%)	6 (2.8%)	99.1 (96.6–99.9)	0.50
HPV 45/51/52^d	6 (2.8%)	7 (3.3%)	96.7 (93.3–98.7)	1.00
HPV 35/39/68^e	13 (6.1%)	12 (5.7%)	96.7 (93.3–98.7)	1.00
HPV 56/59/66^f	3 (1.4%)	5 (2.3%)	96.2 (92.7–98.4)	0.73

CI confidence interval, HPV human papillomavirus
^aMcNemars test
^bHPV16/18: HPV16 and/or HPV18 including co-infections with HPV genotypes of lesser risk (HPV 31, 33, 58, 45, 51, 52, 35, 39, 68, 56, 59 and 66)
^cHPV31/33/58: HPV31 and/or HPV33 and/or HPV58 including co-infections with HPV genotypes of lesser risk (HPV 45, 51, 52, 35, 39, 68, 56, 59 and 66)
^dHPV45/51/52: HPV45 and/or HPV51 and/or HPV52 including co-infections with HPV genotypes of lesser risk (HPV 35, 39, 68, 56, 59 and 66)
^eHPV35/39/68: HPV35 and/or HPV39 and/or HPV68 including co-infections with HPV genotypes of lesser risk (HPV 56, 59 and 66)
^fHPV56/59/66: HPV56 and/or HPV59 and/or HPV66 with no co-infections

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