Fig. 4From: First diagnosed invasive lobular carcinoma of the breast combined with gastric metastasis and bone metastasis: a case report and review of the literatureVASH2 induces EMT pathway: VASH2 induces TGFβ1 expression in vitro and in vivo, and the activated TGFβ pathway downregulates E-cadherin. VASH2 also decreases E-cadherin expression by downregulating GATA3 expression under hypoxic conditions in vitro or in vitro, GATA3 is an ESR1 transcription factor, and the reduction of GATA3 transcript level GATA3 is an ESR1 transcription factor, and the reduction of GATA3 transcript level resulted in the down-regulation of ESR1Back to article page