Fig. 2
From: Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report
The histology and immunophenotype of breast DLBCL with signet ring cells. a The tumour cells are medium to large lymphoid cells with oval to round nuclei, diffusely distributed in the breast interstitium and eroding the breast lobules. b-c Many of the lymphoid cells have intracytoplasmic vacuoles that press the nucleus, imparting a signet ring appearance. Immunohistochemical stains show that the signet ring cell-like lymphocytes are negative for cytokeratin (d) and CD3 (e) and positive for CD79a (f), CD20 (g), and MUM-1 (H). The Ki-67 proliferation index was approximately 70% (I)