Factors associated with health-related quality of life in gynaecologic cancer survivors with lower limb lymphedema: a cross-sectional study in Taiwan

Table 3 Factors significantly associated with overall health-related quality of life related to lower limb lymphoedema and five domains of health-related quality of life related to lower limb lymphoedema based on multiple regression analysis (N = 85)

Domains of health-related quality of life	Predictive Variable	Adjusted R²	Beta	F	p	95% CI
Domains of health-related quality of life	Predictive Variable	Adjusted R²	Beta	F	p	Lower	Upper
Overall health-related quality of life (Lymph-ICF-LL)	Symptom distress (SDS)	0.765	0.576	69.273	0.001	24.488	13.221
	Body image (BIS)		0.345		0.001	6.425	13.678
	Grade of lymphoedema		0.141		0.022	0.442	5.475
	Time since lower limb lymphoedema onset (year)		0.116		0.036	0.019	0.556
	Constant				0.001	−47.626	−26.018
Physical function (Lymph-ICF-LL)	Symptom distress (SDS)	0.675	0.728	88.364	0.001	30.220	44.342
	Body image (BIS)		0.185		0.009	1.299	8.983
	Constant				0.001	−42.528	−18.722
Mental function (Lymph-ICF-LL)	Body image (BIS)	0.672	0.523		0.001	11.814	25.872
	Depression (POMS–Depression and Dejection subscale)		0.371		0.001	4.101	13.007
	Cancer stage (early vs. advanced)		−0.148		0.023	−22.477	−1.729
	Constant
General tasks/household (Lymph-ICF-LL)	Symptom distress (SDS)	0.565	0.642	37.427	0.001	30.525	48.819
	Performance status (KPS)		−0.201		0.010	−0.867	−0.120
	Time since lower limb lymphoedema onset (year)		0.178		0.019	0.087	0.932
	Constant				0.627	−49.006	29.719
Mobility (Lymph-ICF-LL)	Symptom distress (SDS)	0.565	0.643	55.478	0.001	30.932	49.858
	Grade of lymphoedema		0.251		0.001	2.466	9.896
	Constant				0.001	−58.856	−25.376
Life/social life (Lymph-ICF-LL)	Symptom distress (SDS)	0.601	0.511	143.259	0.001	2.831	15.575
	Grade of lymphoedema		0.254		0.001	25.808	48.194
	Body image (BIS)		0.234		0.005	2.887	11.555
	Constant				0.001	−69.620	−31.884

SDS, Symptom Distress Scale, higher scores reflect more symptom distress
BIS, Body Image Scale, higher score indicating greater symptoms or distress about body image
Lymph-ICF-LL, Lymphoedema Functioning, Disability and Health Questionnaire for Lower Limb Lymphoedema, higher score indicating worse QOL.
1. Dependent variable: health-related quality of life (Lymph-ICF-LL).
2. Input independent variable: covariates included cancer stage (early vs. advanced), time since lower limb lymphoedema onset (continuous score), grade of lymphedema, performance status (continuous score), symptom distress (continuous score), depression (continuous score), and body image (continuous score)
CI, confidence interval

ISSN: 1472-6874