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Table 4 Immunostaining levels of ACE2, TMPRSS2, NK1R, ADRB2, CD68, and MPO in endometria collected from cases before and during Covid-19 pandemic

From: Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic

 

Endometrium (pre-pandemic)

(n = 25)

Endometrium (in-pandemic)

(n = 25)

P value

ACE2-stained cells (mean ± SEM)

3.2 ± 0.2

3.1 ± 0.3

0.718

Median

3.0

2.8

 

Range of IRS

1.2–6.4

1.4–7.2

 

TMPRSS2-stained cells (mean ± SEM)

9.7 ± 0.4

8.8 ± 0.6

0.519

Median

9.6

8.6

 

Range of IRS

4.6–12.0

1.8–12.0

 

NK1R (IRS) (mean ± SEM)

5.3 ± 0.5

5.9 ± 0.6

0.283

Median

4.8

5.2

 

Range of IRS

2.0–10.6

1.4–10.6

 

ADRB2 (IRS) (mean ± SEM)

5.0 ± 0.4

6.3 ± 0.5

0.015

Median

4.0

6.4

 

Range of IRS

2.0–10.6

1.8–12.0

 

CD68-stained cells (mean ± SEM)

84.2 ± 9.1

99.6 ± 13.5

0.779

Median

79.2

90.6

 

Range of IR cells

9.8–179.2

0–287.6

 

MPO-stained cells (mean ± SEM)

22.3 ± 6.8

41.1 ± 9.2

0.202

Median

10.6

16.2

 

Range of IR cells

1.6–169

0–179

 
  1. ACE2 angiotensin-converting enzyme 2, TMPRSS2 trans-membrane serine protease 2, NK1R neurokinin receptor 1, ADRB2 beta 2-adrenergic receptor, CD68 marker of macrophages, MPO myeloperoxidase, marker of neutrophils, IR immunoreactive cells, IRS immunoreactive score
  2. *P value after adjusting for covariates by ANCOVA (analysis of covariance)