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Table 3 Demographic and clinicopathological characteristics and the associations with female reproductive tract infections for patient cohort

From: Interaction of reproductive tract infections with estrogen exposure on breast cancer risk and prognosis

Characteristics

Total

Reproductive tract infections

P

N = 4264(%)

Yes (n = 685)

No (n = 3579)

Age (years)

   

< 0.001

  ≤ 40

1023 (24.0)

239 (34.9)

784 (21.9)

 

 41–60

2687 (63.0)

406 (59.3)

2281 (63.8)

 

  > 60

552 (13.0)

40 (5.8)

512 (14.3)

 

 Mean ± SD

48.00 ± 10.69

44.58 ± 9.19

48.65 ± 10.83

< 0.001

Education

   

0.027

 Junior and below

1909 (47.6)

292 (43.7)

1617 (48.4)

 

 Senior and above

2098 (52.4)

376 (56.3)

1722 (51.6)

 

Marital status

   

0.010

 Unmarried

117 (2.8)

7 (1.0)

110 (3.2)

 

 Married/cohabiting

3853 (92.7)

636 (94.5)

3217 (92.4)

 

 Divorced/widowed/separated

185 (4.5)

30 (4.5)

155 (4.5)

 

Age at menarche

   

0.388

  ≤ 12

558 (13.4)

98 (14.5)

460 (13.2)

 

  > 12

3614 (86.6)

580 (85.5)

3034 (86.8)

 

Menopause

   

< 0.001

 Pre

2607 (62.9)

526 (78.2)

2081 (59.9)

 

 Post

1538 (37.1)

147 (21.8)

1391 (40.1)

 

Parity

   

0.004

  ≤ 2

2815 (81.2)

450 (85.7)

2365 (80.4)

 

  > 2

650 (18.8)

75 (14.3)

575 (19.6)

 

Breastfeeding history

   

0.388

 No

548 (13.6)

84 (12.5)

464 (13.8)

 

 Yes

3485 (86.4)

588 (87.5)

2897 (86.2)

 

Family history of breast cancer

   

< 0.001

 No

3718 (89.8)

623 (93.5)

3095 (89.1)

 

 Yes

421 (10.2)

43 (6.5)

378 (10.9)

 

BMI

   

0.010

  < 18.5

245 (6.0)

39 (5.8)

206 (6.0)

 

 18.5–23.9

2412 (58.7)

427 (63.8)

1985 (57.7)

 

  ≥ 24.0

1450 (35.3)

203 (30.3)

1247 (36.3)

 

Oral contraceptive use

   

0.085

 No

1991 (95.5)

294 (93.6)

1697 (95.8)

 

 Yes

94 (4.5)

20 (6.4)

74 (4.2)

 

ER

   

0.269

 Positive

3035 (76.2)

508 (77.9)

2527 (75.8)

 

 Negative

949 (23.8)

144 (22.1)

805 (24.2)

 

PR

   

0.007

 Positive

2668 (67.1)

466 (71.7)

2202 (66.2)

 

 Negative

1306 (32.9)

184 (28.3)

1122 (33.8)

 

HER2

   

< 0.001

 Positive

837 (21.8)

106 (16.6)

731 (22.8)

 

 Equivocal

982 (25.6)

134 (21.0)

848 (26.5)

 

 Negative

2019 (52.6)

397 (62.3)

1622 (50.7)

 

Stage

   

0.515

 I/II

3135.(79.6)

501 (80.7)

2634 (79.4)

 

 III/IV

802.(20.4)

120 (19.3)

682 (20.6)

 
  1. Bold indicates statistically significant values
  2. Note, the total number may not be the same because of the missing data