Table 5 Modification effects of estrogen exposure on the associations between reproductive tract infections and prognosis
Estrogen exposure | Reproductive tract infections | Total | OS | PFS | ||
|---|---|---|---|---|---|---|
Events (%) | HR (95%CI)a | Events (%) | HR (95%CI)a | |||
Number of menstrual cycles | ||||||
  ≤ 327 | No | 873 | 86 (7.7) | 1.00 (reference) | 177 (16.0) | 1.00 (reference) |
Yes | 232 | 17 (7.3) | 0.74 (0.38,1.43) | 45 (19.3) | 1.10 (0.73,1.64) | |
  > 327 | No | 1886 | 149 (7.9) | 1.00 (reference) | 267 (14.1) | 1.00 (reference) |
Yes | 322 | 15 (4.6) | 0.56 (0.24,1.28) | 37 (11.4) | 0.52 (0.34,0.79) | |
P for interaction | Â | 0.286 | 0.015 | |||
Reproductive time -Duration of parity—Breastfeeding duration (years) | ||||||
  ≤ 25 | No | 886 | 67 (7.5) | 1.00 (reference) | 131 (14.7) | 1.00 (reference) |
Yes | 261 | 21 (8.0) | 0.82 (0.44,1.53) | 53 (20.3) | 1.13 (0.82,1.76) | |
  > 25 | No | 1966 | 158 (8.0) | 1.00 (reference) | 280 (14.2) | 1.00 (reference) |
Yes | 341 | 12 (3.5) | 0.42 (0.22,0.80) | 38 (11.1) | 0.56 (0.38,0.84) | |
P for interaction | Â | 0.137 | 0.013 | |||
Reproductive time—Duration of all pregnancies—Breastfeeding duration (years) | ||||||
  ≤ 25 | No | 846 | 67 (7.9) | 1.00 (reference) | 125 (14.7) | 1.00 (reference) |
Yes | 254 | 21 (8.2) | 0.79 (0.43,1.47) | 54 (21.2) | 1.21 (0.83,1.76) | |
  > 25 | No | 1871 | 151 (8.0) | 1.00 (reference) | 272 (14.5) | 1.00 (reference) |
Yes | 324 | 12 (3.7) | 0.43 (0.22,0.82) | 37 (11.4) | 0.54 (0.36,0.81) | |
P for interaction | Â | 0.165 | 0.005 | |||