Table 1 Baseline characteristics of included participants

NLR, Mean (S.E)

2.15 (0.03)

2.09 (0.03)

2.44 (0.06)

 < 0.001

2.14 (0.03)

2.38 (0.07)

0.003

PLR, Mean (S.E)

139.48 (1.58)

137.43 (1.88)

148.67 (3.06)

0.003

139.22 (1.70)

143.89 (3.85)

0.297

MLR, Mean (S.E)

0.29 (0.00)

0.28 (0.00)

0.32 (0.01)

 < 0.001

0.28 (0.00)

0.33 (0.02)

0.003

SII, Mean (S.E)

555.38 (7.60)

537.15 (8.59)

636.88 (15.10)

 < 0.001

552.52 (8.04)

604.40 (24.14)

0.052

SIRI, Mean (S.E)

1.17 (0.02)

1.12 (0.02)

1.43 (0.05)

 < 0.001

1.16 (0.02)

1.44 (0.08)

 < 0.001

AISI, Mean (S.E)

308.33 (5.29)

292.31 (5.68)

379.95 (12.77)

 < 0.001

305.07 (5.40)

364.16 (20.53)

0.007

Age, years, Mean (S.E)

64.85 (0.27)

63.31 (0.30)

71.74 (0.44)

 < 0.001

64.36 (0.29)

73.16 (0.93)

 < 0.001

Race/ethnicity, n (%)

 < 0.001

 < 0.001

 Mexican American

393 (4.54)

331 (4.77)

62 (3.53)

371 (4.56)

22 (4.18)

 Non-Hispanic White

1672 (81.37)

1245 (80.34)

427 (86.00)

1539 (80.97)

133 (88.30)

 Non-Hispanic Black

310 (4.89)

240 (4.73)

70 (5.61)

290 (4.89)

20 (4.82)

 Other race including multi-racial

459 (9.19)

416 (10.16)

43 (4.86)

449 (9.57)

10 (2.69)

Education Level, n (%)

 < 0.001

0.002

 Less than 9th grade

331 (5.54)

251 (4.66)

80 (9.46)

306 (5.31)

25 (9.37)

 9th-11th grade

404 (11.03)

283 (9.60)

121 (17.44)

365 (10.66)

39 (17.41)

 High school grade/GED or equivalent

755 (28.06)

578 (27.37)

177 (31.18)

702 (27.92)

53 (30.50)

 Some college or AA degree

788 (29.05)

643 (29.75)

145 (25.94)

744 (29.28)

44 (25.14)

 College graduate or above

556 (26.31)

477 (28.62)

79 (15.98)

532 (26.82)

24 (17.58)

Marital status, n (%)

 < 0.001

0.020

 Married

1360 (54.63)

1147 (58.13)

213 (38.98)

1293 (55.35)

67 (42.27)

 Never married

147 (3.90)

120 (3.85)

27 (4.13)

135 (3.83)

12 (5.18)

 Other (widowed, divorced, separated, living with partner)

1327 (41.47)

965 (38.02)

362 (56.90)

1221 (40.83)

106 (52.55)

Family PIR, ratio, Mean (S.E)

3.06 (0.05)

3.19 (0.06)

2.51 (0.07)

 < 0.001

3.09 (0.06)

2.63 (0.14)

0.003

Smoked at least 100 cigarettes in life,

0.001

0.156

 Yes

1130 (42.38)

842 (40.56)

288 (50.51)

1057 (42.68)

73 (37.15)

 No

1704 (57.62)

1390 (59.44)

314 (49.49)

1592 (57.32)

112 (62.85)

MET, met*min, Mean (S.E)

544.30 (25.20)

565.48 (26.76)

449.65 (64.33)

0.094

547.60 (25.72)

487.97 (83.85)

0.484

Direct HDL-C, mmol/L, Mean (S.E)

1.60 (0.01)

1.61 (0.01)

1.57 (0.03)

0.123

1.61 (0.01)

1.53 (0.04)

0.021

Total cholesterol, mg/dL, Mean (S.E)

210.12 (1.18)

211.44 (1.24)

204.22 (1.78)

 < 0.001

210.46 (1.19)

204.15 (3.15)

0.047

Glucose, serum, mmol/L, Mean (S.E)

5.57 (0.04)

5.53 (0.04)

5.75 (0.07)

0.006

5.56 (0.04)

5.85 (0.11)

0.010

SBP, mmHg, Mean (S.E)

129.38 (0.55)

127.88 (0.62)

136.08 (1.11)

 < 0.001

128.99 (0.60)

136.06 (1.92)

0.001

DBP, mmHg Mean (S.E)

68.36 (0.45)

69.28 (0.49)

64.28 (0.72)

 < 0.001

68.67 (0.46)

63.13 (1.56)

 < 0.001

BMI, n (%)

0.003

0.272

 Normal\underweight

1074 (41.54)

803 (40.01)

271 (48.38)

988 (41.11)

86 (48.93)

 Overweight

1021 (33.39)

815 (33.88)

206 (31.21)

966 (33.69)

55 (28.40)

 Obese

739 (25.07)

614 (26.11)

125 (20.41)

695 (25.21)

44 (22.66)

Central obesity, n (%)

0.033

0.035

 No

2103 (74.93)

1631 (74.04)

472 (78.89)

1954 (74.50)

149 (82.18)

 Yes

731 (25.07)

601 (25.96)

130 (21.11)

695 (25.50)

36 (17.82)

Osteoporosis, n (%)

 < 0.001

0.002

 No

2333 (84.19)

1903 (86.77)

430 (72.67)

2199 (84.69)

134 (75.71)

 Yes

501 (15.81)

329 (13.23)

172 (27.33)

450 (15.31)

51 (24.29)

Parents ever had fracture, n (%)

0.512

0.728

 No

2470 (85.82)

1954 (86.04)

516 (84.84)

2311 (85.88)

159 (84.68)

 Yes

364 (14.18)

278 (13.96)

86 (15.16)

338 (14.12)

26 (15.32)

Doctor told you have diabetes, n (%)

 < 0.001

 < 0.001

 Yes

406 (10.04)

293 (8.97)

113 (14.84)

363 (9.60)

43 (17.70)

 No

2428 (89.96)

1939 (91.03)

489 (85.16)

2286 (90.40)

142 (82.30)

Family history of CVD, n (%)

0.401

0.803

 Yes

454 (17.26)

355 (16.93)

99 (18.71)

422 (17.21)

32 (18.07)

 No

2380 (82.74)

1877 (83.07)

503 (81.29)

2227 (82.79)

153 (81.93)

History of CVD, n (%)

 < 0.001

 < 0.001

 Yes

440 (13.01)

271 (9.85)

169 (27.13)

381 (11.97)

59 (30.91)

 No

2394 (86.99)

1961 (90.15)

433 (72.87)

2268 (88.03)

126 (69.09)

Energy, kcal, Mean (S.E)

1684.80 (19.94)

1710.97 (23.84)

1567.71 (27.62)

 < 0.001

1710.97 (23.84)

1567.71 (27.62)

 < 0.001

Antihypertensive drug, n (%)

0.094

0.094

 No

2506 (89.36)

1987 (89.93)

519 (86.81)

1987 (89.93)

519 (86.81)

 Yes

328 (10.64)

245 (10.07)

83 (13.19)

245 (10.07)

83 (13.19)

Lipid-lowering drug, n (%)

 < 0.001

 < 0.001

 No

1885 (68.00)

1519 (69.66)

366 (60.55)

1519 (69.66)

366 (60.55)

 Yes

949 (32.00)

713 (30.34)

236 (39.45)

713 (30.34)

236 (39.45)

Osteoporosis drugs, n (%)

0.002

0.002

 No

2545 (89.93)

2028 (90.94)

517 (85.39)

2028 (90.94)

517 (85.39)

 Yes

289 (10.07)

204 (9.06)

85 (14.61)

204 (9.06)

85 (14.61)

Occupation, n (%)

 < 0.001

 < 0.001

 Employee of private company

632 (28.41)

575 (32.14)

57 (11.71)

575 (32.14)

57 (11.71)

 Work for government

171 (6.68)

160 (7.78)

11 (1.78)

160 (7.78)

11 (1.78)

 Self-employed or family business/farm

119 (4.59)

105 (4.77)

14 (3.79)

105 (4.77)

14 (3.79)

 Unknown

1912 (60.32)

1392 (55.31)

520 (82.71)

1392 (55.31)

520 (82.71)

Severity of osteoporosis, n (%)

0.003

0.034

 Osteoporosis

449 (16.81)

320 (15.60)

129 (22.22)

408 (16.40)

41 (23.78)

 Osteopenia

2385 (83.19)

1912 (84.40)

473 (77.78)

2241 (83.60)

144 (76.22)

Survival time, month, Mean (S.E)

113.51 (3.15)

117.00 (3.70)

97.92 (3.72)

 < 0.001

114.40 (3.41)

98.23 (7.29)

0.064