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Table 2 The associations of inflammatory markers with all-cause mortality and CVD mortality in postmenopausal women with osteoporosis or osteopenia

From: Association of inflammatory markers with all-cause mortality and cardiovascular mortality in postmenopausal women with osteoporosis or osteopenia

 

All-cause mortality

CVD mortality

Unadjusted Model

Adjusted Model

Unadjusted Model

Adjusted Model

Variables

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

NLR

1.24 (1.14–1.34)

 < 0.001

1.17 (1.09–1.26)

 < 0.001

1.21 (1.11–1.33)

 < 0.001

1.16 (1.04–1.29)

0.007

PLR

1.06 (0.97–1.16)

0.224

1.05 (0.98–1.13)

0.131

1.00 (0.86–1.16)

0.972

0.98 (0.88–1.09)

0.669

MLR

1.36 (1.29–1.43)

 < 0.001

1.16 (1.08–1.25)

 < 0.001

1.41 (1.31–1.52)

 < 0.001

1.18 (1.05–1.33)

0.005

SII

1.18 (1.10–1.26)

 < 0.001

1.11 (1.04–1.18)

 < 0.001

1.12 (1.00–1.26)

0.043

1.09 (0.97–1.23)

0.156

SIRI

1.36 (1.29–1.44)

 < 0.001

1.21 (1.12–1.30)

 < 0.001

1.37 (1.25–1.51)

 < 0.001

1.27 (1.10–1.46)

 < 0.001

AISI

1.26 (1.18–1.34)

 < 0.001

1.13 (1.06–1.20)

 < 0.001

1.24 (1.10–1.39)

 < 0.001

1.15 (1.01–1.30)

0.032

  1. AISI, neutrophil × monocyte × platelet /lymphocyte ratio, CI Confidence interval, CVD Cardiovascular disease, HR Hazard ratio, MLR Monocyte-to-lymphocyte ratio, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, SII Immune-inflammation index, SIRI Systemic inflammation response index
  2. For the all-cause mortality, age, race, education, marital status, the severity of osteoporosis, poverty-to-income ratio (PIR), smoking status, total cholesterol, glucose, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), central obesity, history of CVD, history of fracture, diabetes, lipid-lowering drugs, osteoporosis drugs, occupation, and energy intake were adjusted for; adjusted covariates for the CVD mortality included age, race, education, marital status, the severity of osteoporosis, PIR, high density lipoprotein cholesterol (HDL-C), total cholesterol, glucose, SBP, DBP, BMI, central obesity, CVD history, fracture history, diabetes, lipid-lowering drugs, and occupation