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Fig. 1 | BMC Women's Health

Fig. 1

From: FOXO3 and PTEN expression in the ovary of girls with extra-gonadal cancer with or without chemotherapy treatment prior to cryopreservation

Fig. 1

Immunodetection of PTEN in the pre- and post-pubertal human ovary with extragonadal oncopathology. A PTEN-immunoreactive (arrowheads) and PTEN-negative (arrows) primordial follicles in a 9-year-old patient that did not receive chemotherapy treatment before sample collection. B Detail of a primordial follicle with cytoplasmic immunoreactivity for PTEN from a 9-year-old patient who received chemotherapy before sample collection. C Primary follicle negative for PTEN (untreated patient). D Secondary follicle negative for PTEN (untreated patient). E Atretic antral follicle with granulosa cells (AGC) and luteal granulosa cells (LGC) positive for (untreated patient); A, antrum. F Detail of luteal body positive for PTEN (treated patient). Insets in (A) show PTEN immunoreactive blood vessels (right inset) from the same section, used as internal positive antibody reactivity control, and negative PTEN blood vessel when primary antibody was preabsorbed with the specific commercial synthetic peptide (left inset)

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BMC Women's Health

ISSN: 1472-6874

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