Table 2 Characteristics of recurrence and secondary cytoreductive surgery
Endometrial Carcinoma(N%) | Uterine Sarcoma(N%) | P-value | |
|---|---|---|---|
Clinical symptoms at recurrence | 0.826 | ||
None | 26 (55.3) | 19 (51.4) | |
Symptomatic | 21 (44.7) | 18 (48.6) | |
Ascites | 0.725 | ||
No | 41 (87.2) | 34 (91.9) | |
Yes | 6 (12.8) | 3 (8.1) | |
Size of largest tumor (cm) | 0.001 | ||
≤ 6 | 41 (87.2) | 19 (51.4) | |
> 6 | 6 (12.8) | 18 (48.6) | |
Number of recurrent tumors | 0.186 | ||
One | 24 (51.1) | 13 (35.1) | |
Several | 23 (48.9) | 24 (64.9) | |
Sites of recurrence | |||
Central pelvis | 20 (42.6) | 27 (73) | |
Lateral pelvis | 4 (8.5) | 11 (29.7) | |
Pelvic lymphnodes | 5 (10.6) | 1 (2.7) | |
Peritoneal dissemination | 10 (21.3) | 17 (45.9) | |
Paraaortic lymphnodes | 7 (14.9) | 2 (5.4) | |
Colon | 3 (6.4) | 7 (18.9) | |
Small intestine | 1 (2.1) | 1 (2.7) | |
Liver | 1 (2.1) | 0 (0) | |
Adrenal gland | 1 (2.1) | 0 (0) | |
Lung | 3 (6.4) | 2 (5.4) | |
Chest wall mass | 0 (0) | 1 (2.7) | |
Mediastinal lymph nodes | 1 (2.1) | 0 (0) | |
Vaginal wall | 8 (17) | 1 (2.7) | |
Vulva | 2 (4.3) | 0 (0) | |
Inguinal lymphnodes | 1 (2.1) | 0 (0) | |
Parietooccipital region | 1 (2.1) | 0 (0) | |
Operative time, h (mean) | 2.85 ± 1.564 | 3.44 ± 1.308 | 0.072 |
Intraoperative bleeding, ml (mean) | 237.23 ± 265.254 | 478.92 ± 594.978 | 0.015 |
Haemoglobin drop, g/dl (mean) | 1.39 ± 1.213 | 2.12 ± 1.711 | 0.025 |
Surgical procedures | |||
Exploratomy laparotomy with biopsy | 2 (4.3) | 0 (0) | |
Pelvic lymphadenectomy | 7 (14.9) | 4 (10.8) | |
Colectomy | 7 (14.9) | 2 (5.4) | |
Rectectomy | 4 (8.6) | 4 (10.8) | |
Ileostomy | 1 (2.1) | 1 (2.7) | |
Bladder resection | 0 (0) | 3 (8.1) | |
Ureteral stents placement | 3 (6.4) | 7 (18.9) | |
Ureterostomy | 0 (0) | 1 (2.7) | |
Ureterovesical reimplantation | 2 (4.3) | 0 (0) | |
Partial ureterectomy | 1 (2.1) | 0 (0) | |
Reconstruction of bladder with ileum | 0 (0) | 1 (2.7) | |
Pelvic mass resection | 6 (12.8) | 16 (43.2) | |
Oophorectomy or oophorosalpingectomy | 2 (4.3) | 8 (21.6) | |
Paraaortic lymphadenectomy | 10 (21.3) | 4 (10.8) | |
Repair of vena cava injury | 1 (2.1) | 0 (0) | |
Omentectomy or Peritoneal dissemination resection | 10 (21.3) | 17 (45.9) | |
Small-bowel resection | 3 (6.4) | 3 (8.1) | |
Partial hepatectomy | 1 (2.1) | 0 (0) | |
Adrenal tumor resection | 1 (2.1) | 0 (0) | |
Appendectomy | 2 (4.3) | 1 (2.7) | |
Vaginectomy or Vaginal stump resection | 16 (34.0) | 4 (10.8) | |
Diaphragmatic tumor resection | 1 (2.1) | 0 (0) | |
Partial urethrectomy | 3 (6.4) | 1 (2.7) | |
Subcutaneous mass excision | 1 (2.1) | 0 (0) | |
Vulvectomy | 3 (6.4) | 0 (0) | |
Inguinal lymph node resection | 1 (2.1) | 0 (0) | |
Abdominal mass resection | 1 (2.1) | 2 (5.4) | |
Chest wall tumor resection | 0 (0) | 1 (2.7) | |
Pulmonary lobectomy | 2 (4.3) | 0 (0) | |
Mediastinal lymphadenectomy | 1 (2.1) | 0 (0) | |
Parietooccipital tumor resection | 1 (2.1) | 0 (0) | |
Complications | |||
None | 35 (74.5) | 28 (75.7) | |
Bleeding | 0 (0) | 1 (2.7) | |
Infection | 3 (6.4) | 4 (10.8) | |
Intestinal fistula | 0 (0) | 1 (2.7) | |
Urinary fistula | 1 (2.1) | 2 (5.4) | |
Ileus | 3 (6.4) | 2 (5.4) | |
Hydrothorax | 1 (2.1) | 0 (0) | |
Lymphocyst | 1 (2.1) | 0 (0) | |
Pelvic effusion | 0 (0) | 1 (2.7) | |
Poor wound healing or herniation | 6 (12.8) | 1 (2.7) | |
Thrombosis | 1 (2.1) | 0 (0) | |
Hydronephrosis | 1 (2.1) | 0 (0) | |
Peripheral neuropathy | 0 (0) | 1 (2.7) | |
Complications that require surgery | |||
No | 44 (93.6) | 34 (91.9) | 1.000 |
Yes | 3 (6.4) | 3 (8.1) | |
Length of hospital stays, day (mean) | 19.98 ± 6.883 | 24.84 ± 7.437 | 0.016 |
Residual disease | 0.010 | ||
None | 38 (80.9) | 20 (54.1) | |
> 0 | 9 (19.1) | 17 (45.9) | |
Neoadjuvent chemotherapy | 0.252 | ||
No | 44 (93.6) | 37 (100) | |
Yes | 3 (6.4) | 0 (0) | |
Adjuvent therapy after SCS | |||
None | 6 (12.8) | 10 (27) | |
Chemotherapy only | 20 (42.6) | 20 (54.1) | |
Radiotherapy only | 9 (19.1) | 2 (5.4) | |
Combined chemoradiotherapy | 0 (0) | 2 (5.4) | |
Hormonal therapy | 12 (25.5) | 2 (5.4) | |
Other | 0 (0) | 1 (2.7) | |
Recurrence | 0.001 | ||
No | 21 (44.7) | 4 (10.8) | |
Yes | 26 (55.3) | 33 (89.2) | |
Death | 0.007 | ||
No | 26 (55.3) | 9 (24.3) | |
Yes | 21 (44.7) | 28 (75.7) |