Table 4 Univariate and multivariate analyses of survival after SCS in patients with uterine sarcoma

Age at recurrence (years)

0.004

0.345

0.006

0.006

 < 60

1

1

1

1

 ≥ 60

4.265 (1.572–11.574)

2.153 (0.438–10.577)

3.511 (1.424–8.656)

3.868 (1.469–10.185)

ECOG performance status before SCR

0.031

0.237

0.069

 0

1

1

1

 1–2

3.232 (1.113–9.388)

3.000 (0.485–18.550)

2.521 (0.932–6.821)

FIGO stage at initial diagnosis

0.362

0.533

 I/II

1

1

 III/IV

1.575 (0.593–4.183)

1.408 (0.481–4.122)

Histology

 Uterine leiomyosarcoma

1

1

 Low-grade ESS

0.566 (0.246–1.299)

0.179

0.610 (0.250–1.491)

0.279

 High-grade ESS

1.493 (0.430–5.185)

0.528

1.454 (0.415–5.095)

0.559

 Other

0.645 (0.187–2.222)

0.487

0.615 (0.140–2.693)

0.518

Clinical symptoms at recurrence

0.776

0.814

 No

1

1

 Symptomatic

0.905 (0.456–1.797)

0.915 (0.435–1.924)

Size of largest tumor (cm)

0.774

0.643

 ≤ 6

1

1

 > 6

0.904 (0.455–1.798)

0.839 (0.398–1.767)

Number of recurrent tumors

0.016

0.532

0.036

0.925

 One

1

1

1

1

 Several

2.523 (1.187–5.362)

1.333 (0.541–3.287)

2.471 (1.063–5.742)

0.947 (0.308–2.910)

DFI before SCS (months)

0.090

0.034

0.024

 < 12

1

1

1

 ≥ 12

0.540 (0.265–1.101)

0.414 (0.183–0.934)

0.341 (0.134–0.870)

Retroperitoneal lymph node metastasis

0.820

0.616

 No

1

1

 Yes

1.182 (0.280–5.001)

0.599 (0.081–4.429)

Distant metastasis

0.601

0.842

 No

1

1

 Yes

0.728 (0.221–2.394)

1.131 (0.339–3.775)

Peritoneal dissemination

0.004

0.007

0.021

0.006

 No

1

1

1

1

 Yes

2.926 (1.404–6.096)

3.118 (1.356–7.169)

2.458 (1.144–5.282)

3.672 (1.441–9.361)

Ascites

0.498

0.534

 None

1

1

 Yes

0.662 (0.201–2.184)

0.633 (0.150–2.675)

Residual disease

0.002

0.026

0.017

0.789

 None

1

1

1

1

 > 0

3.239 (1.563–6.711)

2.662 (1.122–6.319)

2.531 (1.182–5.421)

1.138 (0.443–2.924)

Adjuvant therapy after SCS

 None

1

1

 Chemotherapy only

0.753 (0.347–1.634)

0.472

0.652 (0.284–1.495)

0.312

 Radiotherapy only

0.832 (0.180–3.849)

0.814

0.444 (0.056–3.512)

0.441

 CCRT

0.338 (0.043–2.677)

0.304

0.562 (0.071–4.458)

0.586

 Hormonal therapy

0.312 (0.040–2.467)

0.270

0.402 (0.051–3.191)

0.389

 Other

14.008 (1.211-162.075)

0.035

2.497 (0.297–21.022)

0.400