Table 1 Causal estimations of gut microbiota on endometriosis in the MR analysis
From: Causal effects of gut microbiome on endometriosis: a two-sample mendelian randomization study
Bacterial taxa (exposure) | MR method | F-value | No. of SNP | OR (95%CI) | P-value | |
|---|---|---|---|---|---|---|
Family | Clostridiales_vadin_BB60_group | IVW | 41.99 | 15 | 0.86 (0.78 ~ 0.95) | < 0.01 |
MR-Egger | 15 | 0.97 (0.74 ~ 1.27) | 0.828 | |||
Weighted median | 15 | 0.86 (0.75 ~ 0.99) | 0.038 | |||
Weighted mode | 15 | 0.87 (0.70 ~ 1.08) | 0.216 | |||
Simple mode | 15 | 0.84 (0.66 ~ 1.06) | 0.168 | |||
Family | Oxalobacteraceae | IVW | 89.19 | 14 | 0.91 (0.85 ~ 0.98) | 0.014 |
MR-Egger | 14 | 0.83 (0.63 ~ 1.10) | 0.213 | |||
Weighted median | 14 | 0.95 (0.85 ~ 1.05) | 0.304 | |||
Weighted mode | 14 | 0.99 (0.84 ~ 1.17) | 0.904 | |||
Simple mode | 14 | 1.00 (0.83 ~ 1.19) | 0.984 | |||
Family | Porphyromonadaceae | IVW | 22.08 | 9 | 1.27 (1.03 ~ 1.56) | 0.027 |
MR-Egger | 9 | 1.84 (0.71 ~ 4.80) | 0.250 | |||
Weighted median | 9 | 1.06 (0.82 ~ 1.36) | 0.677 | |||
Weighted mode | 9 | 1.03 (0.71 ~ 1.48) | 0.888 | |||
Simple mode | 9 | 1.03 (0.66 ~ 1.61) | 0.908 | |||
Genus | Anaerotruncus | IVW | 26.63 | 13 | 1.29 (1.07 ~ 1.55) | < 0.01 |
MR-Egger | 13 | 1.13 (0.64 ~ 1.98) | 0.681 | |||
Weighted median | 13 | 1.22 (1.00 ~ 1.49) | 0.054 | |||
Weighted mode | 13 | 1.26 (0.96 ~ 1.66) | 0.127 | |||
Simple mode | 13 | 1.26 (0.94 ~ 1.71) | 0.152 | |||
Genus | Desulfovibrio | IVW | 51.27 | 10 | 0.88 (0.78 ~ 1.00) | 0.046 |
MR-Egger | 10 | 0.78 (0.54 ~ 1.11) | 0.200 | |||
Weighted median | 10 | 0.92 (0.77 ~ 1.09) | 0.318 | |||
Weighted mode | 10 | 0.92 (0.77 ~ 1.09) | 0.732 | |||
Simple mode | 10 | 0.94 (0.69 ~ 1.28) | 0.701 | |||
Genus | Haemophilus | IVW | 60.90 | 9 | 0.89 (0.80 ~ 0.99) | 0.039 |
MR-Egger | 9 | 0.90 (0.71 ~ 1.15) | 0.432 | |||
Weighted median | 9 | 0.93 (0.81 ~ 1.07) | 0.305 | |||
Weighted mode | 9 | 0.93 (0.78 ~ 1.10) | 0.430 | |||
Simple mode | 9 | 0.93 (0.77 ~ 1.13) | 0.497 | |||
Genus | Holdemania | IVW | 50.31 | 14 | 0.88 (0.78 ~ 0.98) | 0.025 |
MR-Egger | 14 | 0.78 (0.56 ~ 1.10) | 0.184 | |||
Weighted median | 14 | 0.94 (0.81 ~ 1.09) | 0.402 | |||
Weighted mode | 14 | 0.95 (0.77 ~ 1.17) | 0.647 | |||
Simple mode | 14 | 0.95 (0.76 ~ 1.21) | 0.705 | |||