Single versus double blastocyst transfer in first and second frozen-thawed embryo transfer cycle in advance-aged women: a two-center retrospective cohort study

Table 4 Logistic regression analysis for live birth in DBT cycles compared with SBT cycles stratified by maternal age

Age (years)	Cycle rank	Group	N miscarriages/N cycles (MR per cycle, %)	N live-births/N cycles (LBR per cycle, %)	Adjusted OR (95% CI) ^*	P-value
35–37	Cycle 1 (n = 616)	SBT	30/271 (11.1)	121/271 (44.6)	Reference	0.001
		DBT	44/345 (12.8)	201/345 (58.3)	1.75 (1.27–2.43) ^a
	Cycle 2 (n = 197)	SBT	7/84 (8.3)	37/84 (44.0)	Reference	0.936
		DBT	15/113 (13.3)	51/113 (45.1)	0.94 (0.52–1.70) ^b
38–42	Cycle 1 (n = 324)	SBT	15/155 (9.7)	49/155 (31.6)	Reference	0.122
		DBT	22/169 (13.0)	68/169 (40.2)	1.45 (0.91–2.31) ^c
	Cycle 2 (n = 147)	SBT	5/75 (6.7)	16/75 (21.3)	Reference	0.036
		DBT	11/72 (15.3)	31/72 (43.1)	2.27 (1.05–4.90) ^d

N Number, LBR live birth rates, MR miscarriage rate, SBT Single blastocyst transfer, DBT Double blastocyst transfer, OR Odds ratio, CI Confidence interval
^*Adjusted for basal FSH and N of good-quality blastocyst transferred (1 or 2 vs. 0)
^aP value = 0.825 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit
^bP value = 0.929 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit
^cP value = 0.612 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit
^dP value = 0.372 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit

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