Table 2 Description of clinical data

Time since diagnosis

≤ 1year

> 1year

10[6-13.75]

171(74.3)

59(25.7)

-

11.97 ± 3.86

12.86 ± 4.91

0.090

0.208

-

13.88 ± 4.01

15.27 ± 4.29

0.009***

0.025*

Histological type

Invasive breast carcinoma

In situ carcinoma

Other

222(96.5)

6(2.6)

2(0.9)

12.24 ± 4.18

10.17 ± 2.86

13.50 ± 4.95

0.440

14.32 ± 4.11

13.00 ± 4.00

9.00 ± 2.83

0.146

Molecular type

Luminal A

Luminal B

HER+

Triple negative

Non-class

92(40)

71(30.9)

30(13)

31(13.5)

6(2.6)

12.35 ± 4.44

11.14 ± 3.51

13.10 ± 4.33

13.48 ± 4.27

11.33 ± 3.33

0.052

14.20 ± 4.37

13.37 ± 3.86

15.27 ± 4.02

15.45 ± 3.79

13.83 ± 3.92

0.098

SBR grade

Grade I

Grade II

Grade III

5(2.2)

125(54.3)

100(43.5)

10.80 ± 4.66

11.91 ± 3.91

12.63 ± 4.43

0.329

11.20 ± 5.76

14.06 ± 4.19

14.62 ± 3.91

0.149

TNM Stage

Stage I-II

Stage III

Stage IV

87(39.3)

94(42.5)

40(18.1)

10.86 ± 4.22

12.33 ± 3.72

14.55 ± 3.88

< 0.001**

12.75 ± 3.89

14.57 ± 3.94

16.45 ± 3.61

< 0.001**

Chemotherapy

Yes

No

228(99.1)

2(0.9)

12.19 ± 4.16

13.50 ± 4.95

0.658

14.28 ± 4.11

9.00 ± 2.83

0.071

Hormonotherapy

Yes

No

123(53.5)

107(46.5)

11.85 ± 3.88

12.61 ± 4.44

0.171

14.05 ± 3.84

14.46 ± 4.43

0.459

Targeted therapy

Yes

No

100(43.5)

130(56.5)

11.63 ± 3.87

12.64 ± 4.33

0.068

13.76 ± 3.87

14.61 ± 4.29

0.122

Radiotherapy

Yes

No

176(76.5)

54(23.5)

12.22 ± 4.28

12.13 ± 3.79

0.887

14.20 ± 4.16

14.37 ± 4.04

0.790

Surgery

Lumpectomy

Mastectomy

No

47(20.4)

157(68.3)

26(11.3)

10.94 ± 4.77

12.40 ± 3.89

13.27 ± 4.24

0.040**

13.06 ± 4.06

14.37 ± 4.03

15.58 ± 4.41

0.034**

Recurrence

Yes

No

15(6.5)

215(93.5)

17.27 ± 3.63

11.85 ± 3.97

< 0.001*

17.73 ± 4.03

13.99 ± 4.03

< 0.001*