Table 4 Drug tolerability and adverse events compared between the CC + letrozole and CC alone groups
Event | Letrozole + CC group (n = 48) | Clomiphene citrate group (n = 47) | P-values |
|---|---|---|---|
Anaphylaxis, n | 0 | 0 | – |
Minor side effects, n (%) | 24 (50) | 22 (46.8) | 0.916 |
Side-effects acceptable | 24 (100) | 22 (100) | – |
Reported side-effects, n (%) | |||
Headache | 3 (12.5) | 1 (4.5) | 0.609 |
Dizziness | 2 (8.3) | 4 (18.2) | 0.405 |
Hot flush | 5 (20.8) | 1 (4.5) | 0.190 |
Abdominal bloating | 7 (29.2) | 6 (27.3) | 1.000 |
Abdominal pain including cramping | 3 (12.5) | 2 (9.1) | 1.000 |
Nausea | 2 (8.3) | 1 (4.5) | 1.000 |
Mood changes | 4 (16.7) | 3 (13.6) | 1.000 |
Fatigue | 5 (20.8) | 3 (13.6) | 0.702 |
Breast discomfort | 5 (20.8) | 5 (22.7) | 1.000 |
Diarrhea | 5 (20.8) | 2 (9.1) | 0.418 |
Night sweats | 4 (16.7) | 1 (4.5) | 0.349 |
Sleep disturbance | 3 (12.5) | 5 (22.7) | 0.451 |
Adverse events of ongoing pregnancy, n (%) | |||
Spontaneous complete abortion | 1 (2.08) | 1 (2.13) | NA* |
Early pregnancy loss | 1 (2.08) | 1 (2.13) | NA* |