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Table 1 Patient characteristics and analyses based on recurrence-free survival status

From: Prediction of recurrence-related factors for patients with early-stage cervical cancer following radical hysterectomy and adjuvant radiotherapy

Parameter

n (%a)

Total recurrence

5-y RR

5-y RFS

p-value

n(%)

%

n (%b)

Age

     

 ≤ 40

45 (14.5)

11

24.4

34(72.6)

0.431

 40–60

199(64.2)

37

16.6

166(81.2)

 > 60

66 (21.3)

12

18.2

54(77.3)

FIGO clinical stage (2009)

    

0.002

 I B1

26

3

11.5

23(88.1%)

 I B2

109 (31.9)

15

13.7

94(84.6%)

 II A1

91 (33.1)

18

18.7

74(79.7%)

 II A2

84(7.6)

24

27.4

61(69.3%)

FIGO surgical restage (2018)

    

< 0.001*

 I

83(26.8)

6

7.2

77(92.5)

  I B1

17(5.5%)

1

5.9

16(94.1%)

  I B2

40(12.9%)

3

7.5

37(92.0%)

  I B3

26(8.4%)

2

7.7

24(92.3%)

 II

101 (32.6)

16

14.1

85(85.1)

  II A1

50(16.1%)

7

12

44(86.9%)

  II A2

29(9.4%)

3

31

27(91.2)

  II B

22(7.1%)

6

27.3

16(72.7%)

 III C1

104 (33.5)

26

25

78(75.7%)

 III C2

22(7.1)

12

54.5

10(42.4%)

Risk factors

    

< 0.001

 high-risk

145

44

34.5

95(65.5)

 intermediate-risk

165

16

9.1

150(90.9)

Parametrial invasion

    

< 0.001

 Pos

28(9.0)

19

62.9

9(32.1)

 Neg

282(91.0)

41

16.7

234(83.3)

Positive vaginal margin

    

0.006

 Pos

17(5.5)

8

47.1

9(52.9)

 Neg

293(94.5)

52

19.1

237(80.9)

No. of LN+

    

< 0.001

 ≥ 3

44(14.2)

20

52.3

21(47.7)

 1–2

82(26.5)

18

24.4

62(75.6)

0

184(59.3)

22

11.4

163(88.6)

Depth of stromal invasion

   

0.022

 Deep 1/3

204(65.8)

47

25

153(75)

 Middle 1/3

77(24.8)

11

14.3

66(85.7)

 Superficial 1/3

29(9.4)

2

6.9

27(93.1)

Tumor diameter

    

< 0.001

 > 4 cm

123(39.7)

40

34.2

81(65.8)

 ≤ 4 cm

187(60.3)

20

11.8

165(88.2)

LVSI

    

0.029

 Pos

203(65.5)

44

24.6

153(75.4)

 Neg

107(34.5)

16

14

92(86.0)

Nerve invasion

    

0.161

 Pos

41(13.2)

10

29.3

29(70.7)

 Neg

269(86.8)

50

19.7

216(80.3)

Vaginal invasion

     

 Yes

110(35.5)

26

23.6

83(75.5)

0.171

 No

200(64.5)

34

17

164(82)

Histological type

    

0.535

 SCC

265 (85.5)

49

20.4

211(79.6)

 Non-SCC

45 (14.5)

11

24.5

34(75.5)

  1. a percentage in the whole patients, b percentage in each subgroup. *compared RR difference among stage I, II, IIIC1 and IIIC2
  2. Abbreviation: RR: recurrence rate; RFS: recurrence-free survival; FIGO, International Federation of Gynecology and Obstetrics; LVSI, lymphovascular space involvement; SCC, squamous cell carcinoma. p-values were compared RR difference among subgroups of clinical/demographic factor.
  3. Bold font: p-value < 0.05