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Fig. 5 | BMC Women's Health

Fig. 5

From: Fanconi anemia complementation group D2 promotes sensitivity of endometrial cancer cells to chemotherapeutic agents by inhibiting the ferroptosis pathway

Fig. 5

Knock-down of Fancd2 increased the sensitivity of Ishikawa/TAX cells to paclitaxel by promoting ferroptosis. A, B Flow cytometry was adopted to detect the level of reactive oxygen species (ROS) in Ishikawa/TAX cells. C–B Malondialdehyde (MDA) activity (C), glutathione (GSH) level (D), and Fe2+ (E) in Ishikawa/TAX cells. F The protein expression levels of SLC7A11 and GPX4 in Ishikawa/TAX cells were assessed via western blot. ** P < 0.01 vs. siNC; ## P < 0.01 vs. si-Fancd2; $$ P < 0.01, vs. Fer-1

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BMC Women's Health

ISSN: 1472-6874

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