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Table 3 Genotype frequencies in all study participants

From: Micronutrients intake and genetic variants associated with premature ovarian insufficiency; MASHAD cohort study

Polymorphism Genotype

Total

Genotype frequency in POI, N (%) (Observed)

Genotype Frequency in Control, N (%) (Observed)

P-Value

Genotype frequency in POI, N (%) (Expected)

Genotype Frequency in Control, N (%) (Expected)

 

rs4806660

   

TT

144

50 (34.7)

94 (65.3)

0.020

49.88 (42.64)

99.38 (54.31)

0.2

TC

135

53 (39.3)

82 (60.7)

52.86 (45.18)

70.65 (38.61)

CC

21

14 (66.7)

7 (33.3)

14.00 (11.97)

12.55 (6.86)

T

 

153 (65.3)

270 (73.7)

    

C

 

81 (34.6)

96 (26.2)

    

rs451417

   

CC

135

58 (35.6)

87 (64.4)

0.001

56.01 (47.88)

85.35 (46.64)

0.1

CA

112

46 (32.1)

76 (67.9)

49.70 (42.48)

78.98 (43.16)

AA

53

13 (62.3)

20 (37.7)

11.02 (9.42)

18.26 (9.98)

C

 

162 (69.2)

250 (68.3)

    

A

 

72 (30.7)

116 (31.6)

    

rs16991615

   

GG

134

47 (35.8)

96 (64.2)

0.002

38.80 (33.17)

93.01 (50.83)

0.2

GA

119

41 (33.6)

69 (66.4)

57.00 (48.72)

74.62 (40.78)

AA

47

29 (61.7)

18 (38.3)

20.93 (17.89)

14.95 (8.17)

G

 

135 (57.6)

261 (71.3)

    

A

 

99 (42.3)

105 (28.6)

    

rs7246479

   

TT

125

36 (28.8)

89 (71.2)

0.002

41.27 (35.28)

95.12 (51.98)

0.2

TA

153

67 (43.7)

86 (56.2)

56.28 (48.11)

73.34 (40.08)

AA

22

14 (63.6)

8 (36.3)

19.18 (16.40)

24.10 (13.17)

T

 

139 (59.4)

264 (72.1)

    

A

 

95 (40.5)

102 (27.8)

    

rs244715

   

AA

172

59 (32.6)

116 (67.4)

0.006

57.33 (49.0)

117.12 (64.0)

0.3

AG

110

46 (44.5)

61 (55.5)

48.97 (41.86)

58.26 (31.84)

GG

18

12 (66.7)

6 (33.6)

10.45 (8.94)

7.24 (3.96)

A

 

164 (70.0)

293 (80.0)

    

G

 

70 (29.9)

73 (19.9)

    

rs1046089

   

GG

108

37 (34.3)

81 (65.7)

0.200

37.74 (32.26)

85.86 (46.92)

0.1

GA

158

59 (43.7)

89 (56.3)

57.28 (48.96)

78.70 (43.01)

AA

34

21 (32.4)

13 (67.6)

21.72 (18.57)

19.58 (10.70)

G

 

133 (56.8)

251 (68.5)

    

A

 

101 (43.1)

115 (31.4)

    

rs2303369

   

CC

119

42 (35.3)

77 (64.7)

0.050

40.58 (34.69)

81.16 (44.35)

0.1

CT

144

54 (37.5)

90 (62.5)

56.49 (48.29)

81.16 (44.35)

TT

37

21 (56.8)

16 (43.2)

19.66 (16.81)

20.27 (11.08)

C

 

138 (58.9)

244 (66.6)

    

T

 

96 (41.0)

122 (33.3)

    

rs10183486

   

CC

140

47 (33.6)

93 (66.4)

0.020

27.22 (23.27)

97.24 (53.14)

0.2

CT

136

55 (40.4)

81 (59.6)

54.01 (46.17)

72.02 (39.36)

TT

24

15 (62.5)

9 (37.5)

15.28 (13.06)

13.34 (7.29)

C

 

149 (63.6)

267 (72.9)

    

T

 

85 (36.3)

99 (27.0)

    
  1. POI: premature ovarian insufficiency; Chi-square test has been used
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