Micronutrients intake and genetic variants associated with premature ovarian insufficiency; MASHAD cohort study

Mirinezhad, Mohammad Reza; Aghsizadeh, Maliheh; Ghazizadeh, Hamideh; Ghoflchi, Sahar; Bidary, Mohammad Zamiri; Naghipour, Alireza; Ferns, Gordon A.; Hamzehloei, Tayebeh; Pasdar, Alireza; Ghayour-Mobarhan, Majid

doi:10.1186/s12905-023-02865-4

BMC Women's Health

Table 4 Association of genotypes with serum mineral concentrations in the patients with POI (N = 117)

From: Micronutrients intake and genetic variants associated with premature ovarian insufficiency; MASHAD cohort study

Polymorphism	Zinc	P-value	copper	P-value	Phosphate	P-value	Calcium	P-value	Vitamin D	P-value	Magnesium	P-value
rs4806660
TT	87.37 ± 3.8	NS	104.43 ± 8.5	NS	4.3 ± 0.06	NS	9.6 ± 0.1^b	0.002	22.24 ± 5.2	NS	1.03 ± 0.03	NS
TC	84.26 ± 2.1		107.8 ± 5.3		4.5 ± 014		8.9 ± 0.5^a		17.58 ± 3.3		1.07 ± 0.03
CC	87.6 ± 7.6		126.1 ± 10.8		4.6 ± 0.4		10.3 ± 0.2^ab		15.48 ± 2.5		1.05 ± 0.02
rs451417
CC	87.7 ± 3.03	NS	108.4 ± 7.3	NS	4.3 ± 0.06^b	0.010	9.5 ± 0.1	NS	21.11 ± 4.4	NS	1.02 ± 0.03	NS
CA	80.9 ± 2.4		116.9 ± 5.8		4.2 ± 0.1^a		8.2 ± 1.1		15.87 ± 4.8		1.07 ± 0.05
AA	84.6 ± 4.6		97.3 ± 8.9		4.7 ± 0.1^ab		9.7 ± 0.1		18.37 ± 4.1		1.08 ± 0.02
rs16991615
GG	87.3 ± 3.07	NS	103.3 ± 7.07	NS	4.5 ± 0.12	NS	9.6 ± 0.1	NS	23.2 ± 4.4	NS	1.07 ± 0.03	NS
GA	86.04 ± 3.3		11.3 ± 6.4		4.4 ± 1.3		9.4 ± 0.2		13.7 ± 4.8		1.03 ± 0.04
AA	87.26 ± 3.2		113.5 ± 9.4		4.8 ± 0.17		8.6 ± 1.08		17.35 ± 4.1		1.03 ± 0.03
rs7246479
TT	87.3 ± 3.8	NS	104.4 ± 8.5	NS	4.3 ± 0.06	NS	9.6 ± 0.1	NS	22.2 ± 5.2	NS	1.04 ± 0.06	NS
TA	84.2 ± 2.1		107.8 ± 5.3		4.5 ± 0.1		8.9 ± 0.5		17.5 ± 3.3		1.03 ± 0.03
AA	78.6 ± 7.6		126.1 ± 10.8		4.6 ± 0.4		10.3 ± 0.2		15.4 ± 2.5		1.07 ± 0.03
rs244715
AA	87.4 ± 2.7	NS	99.4 ± 6^b	0.007	4.5 ± 0.1	NS	9.4 ± 0.1	NS	21.9 ± 5	NS	1.07 ± 0.03	NS
AG	84.9 ± 3.1		108.9 ± 4.6^a		4.4 ± 0.1		8.8 ± 0.7		16.8 ± 3.3		1.04 ± 0.02
GG	73.5 ± 3		142 ± 10.3^ab		4.4 ± 0.2		10.3 ± 0.2		17.04 ± 2.1		0.9 ± 0.04
rs1046089
GG	94.8 ± 3.1	NS	103.4 ± 7.6	NS	4.4 ± 0.09	NS	9.5 ± 0.1	NS	25.4 ± 4.8	NS	1.04 ± 0.02	NS
GA	85.9 ± 2.7		110.3 ± 5.5		4.5 ± 0.1		8.9 ± 0.6		15.6 ± 3		1.07 ± 0.04
AA	77.4 ± 3.5		117.1 ± 14.2		4.3 ± 0.1		10.0 ± 0.5		11.4 ± 5.5		1.05 ± 0.02
rs2303369
CC	84.8 ± 2.8	NS	114.2 ± 7.2	NS	4.1 ± 0.1	NS	9.3 ± 0.2	NS	20.1 ± 5.6	NS	0.9 ± 0.04	NS
CT	84.8 ± 3.1		106.8 ± 6.3		4.5 ± 0.1		9.6 ± 0.09		18.9 ± 3.3		1.09 ± 0.02
TT	83.6 ± 3.3		102.07 ± 9.07		4.6 ± 0.1		8.2 ± 1.7		17.06 ± 5.9		1.03 ± 0.3
rs10183486
CC	82.3 ± 2.4	NS	106.7 ± 6.4	NS	4.3 ± 0.09	NS	9.03 ± 0.54	NS	20.9 ± 3.5	NS	1.04 ± 0.03	NS
CT	87.3 ± 3.09		112.2 ± 6.5		4.4 ± 0.12		9.5 ± 0.18		17.39 ± 4.2		1.03 ± 0.03
TT	83.5 ± 7.2		102.3 ± 12.4		5.0 ± 0.3		9.7 ± 0.35		18.4 ± 2.9		1.14 ± 0.03

One-way Analysis of Variance (ANOVA) and Tukey tests were applied; Data are represented as Mean ± SD (Standard Deviation); All data regarding the concentrations of all micronutrients had normal distribution. a,b & c:same letters show significant differences between genotypes

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