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Table 6 Multivariable logistic regression analysis; Most common genotypes significantly associated with the minerals

From: Micronutrients intake and genetic variants associated with premature ovarian insufficiency; MASHAD cohort study

Polymorphism (Reference Dominant Homozygous genotype)

Serum (µg/dL)

POI cases

Control

OR* (95% CI)

P

OR* (95% CI)

P

OR* (95% CI)

P

OR* (95% CI)

P

rs4806660 (TT)

Cu

TC

CC

TC

CC

 

Ë‚80

0.22 (0.11–0.81)

0.03

0.78 (0.12–2.6)

0.6

0.6 (0.25–1.6)

0.3

3.2 (0.4–24)

0.2

 

80–155

Ref

 

Ref

 

Ref

 

Ref

 
 

> 155

0.17 (0.01–1.5)

0.1

0.32 (0.03–3.02)

0.3

1.2 (0.11–13.01)

0.8

0.5 (0.16–1.8)

0.3

rs7246479 (TT)

Cu

TA

AA

TA

AA

 

Ë‚80

1.4 (0.49–4.5)

0.4

0.38 (0.03–3.7)

0.4

0.8 (0.3-2)

0.6

2.7 (0.2–34.1)

0.4

 

80–155

Ref

 

Ref

 

Ref

 

Ref

 
 

> 155

1.2 (0.3–5.05)

0.7

0.9 (0.1–7.2)

0.9

3.04 (0.7–12.1)

0.1

41.08 (3.7-450.8)

0.002

rs244715 (AA)

Cu

AG

GG

AG

GG

 

Ë‚80

0.36 (0.12–1.05)

0.06

0.29 (0.03–2.7)

0.2

1.7 (0.3–3.6)

0.9

5.7 (0.7-45.06)

0.09

 

80–155

Ref

 

Ref

 

Ref

 

Ref

 
 

> 155

1.2 (0.28–5.3)

0.7

6.7 (1.3–24.3)

0.02

0.6 (0.2–1.8)

0.4

1.17 (0.11–12.3)

0.8

rs1046089 (GG)

Cu

GA

AA

GA

AA

 

Ë‚80

0.7 (0.25–2.05)

0.5

1.19 (0.2–6.4)

0.8

0.7 (0.3–1.9)

0.5

0.7 (0.13–3.6)

0.6

 

80–155

Ref

 

Ref

 

Ref

 

Ref

 
 

> 155

0.6 (0.1–2.3)

0.5

1.2 (0.17–8.8)

0.8

0.3 (0.08–1.2)

0.9

1.8 (0.4–8.1)

0.3

rs2303369 (CC)

Cu

CT

TT

CT

TT

 

Ë‚80

0.4 (0.1–1.5)

0.2

0.2 (0.04–1.2)

0.08

0.8 (0.3–2.1)

0.7

0.5 (0.06–5.06)

0.6

 

80–155

Ref

 

Ref

 

Ref

 

Ref

 
 

> 155

0.5 (0.1–2.1)

0.4

0.2 (0.02–2.03)

0.1

0.2 (0.07–1.11)

0.07

2.01 (0.3–10.7)

0.4

rs4806660 (TT)

Calcium

TC

CC

TC

CC

 

9.5>

13.7 (0.2–65.6)

0.1

0.07 (0.002-3.4)

0.1

7.8 (0.98–34.3)

0.9

6.8 (0.64–72.8)

0.1

 

9.5<

Ref

Ref

Ref

Ref

rs451417 (AA)

Phosphate

CC

CA

CC

CA

 

4.5>

10.5 (0.2–45.7)

0.2

3.2 (0.09–10.8)

0.5

2.02 (0.1–39.3)

0.6

0.4 (0.04–4.2)

0.4

 

4.5<

Ref

Ref

Ref

Ref

  1. POI: Premature Ovarian Insufficiency, OR: Odds Ratio, CI: Confidence Interval; Multivariable logistic regression analysis was performed after adjusting for confounding factors including age and BMI; Dominant homozygous of each SNPs was considered as the reference genotype in the regression analysis