Polymorphism (Reference Dominant Homozygous genotype) | Serum (µg/dL) | POI cases | Control | ||||||
---|---|---|---|---|---|---|---|---|---|
OR* (95% CI) | P | OR* (95% CI) | P | OR* (95% CI) | P | OR* (95% CI) | P | ||
rs4806660 (TT) | Cu | TC | CC | TC | CC | ||||
 | ˂80 | 0.22 (0.11–0.81) | 0.03 | 0.78 (0.12–2.6) | 0.6 | 0.6 (0.25–1.6) | 0.3 | 3.2 (0.4–24) | 0.2 |
 | 80–155 | Ref |  | Ref |  | Ref |  | Ref |  |
 | > 155 | 0.17 (0.01–1.5) | 0.1 | 0.32 (0.03–3.02) | 0.3 | 1.2 (0.11–13.01) | 0.8 | 0.5 (0.16–1.8) | 0.3 |
rs7246479 (TT) | Cu | TA | AA | TA | AA | ||||
 | ˂80 | 1.4 (0.49–4.5) | 0.4 | 0.38 (0.03–3.7) | 0.4 | 0.8 (0.3-2) | 0.6 | 2.7 (0.2–34.1) | 0.4 |
 | 80–155 | Ref |  | Ref |  | Ref |  | Ref |  |
 | > 155 | 1.2 (0.3–5.05) | 0.7 | 0.9 (0.1–7.2) | 0.9 | 3.04 (0.7–12.1) | 0.1 | 41.08 (3.7-450.8) | 0.002 |
rs244715 (AA) | Cu | AG | GG | AG | GG | ||||
 | ˂80 | 0.36 (0.12–1.05) | 0.06 | 0.29 (0.03–2.7) | 0.2 | 1.7 (0.3–3.6) | 0.9 | 5.7 (0.7-45.06) | 0.09 |
 | 80–155 | Ref |  | Ref |  | Ref |  | Ref |  |
 | > 155 | 1.2 (0.28–5.3) | 0.7 | 6.7 (1.3–24.3) | 0.02 | 0.6 (0.2–1.8) | 0.4 | 1.17 (0.11–12.3) | 0.8 |
rs1046089 (GG) | Cu | GA | AA | GA | AA | ||||
 | ˂80 | 0.7 (0.25–2.05) | 0.5 | 1.19 (0.2–6.4) | 0.8 | 0.7 (0.3–1.9) | 0.5 | 0.7 (0.13–3.6) | 0.6 |
 | 80–155 | Ref |  | Ref |  | Ref |  | Ref |  |
 | > 155 | 0.6 (0.1–2.3) | 0.5 | 1.2 (0.17–8.8) | 0.8 | 0.3 (0.08–1.2) | 0.9 | 1.8 (0.4–8.1) | 0.3 |
rs2303369 (CC) | Cu | CT | TT | CT | TT | ||||
 | ˂80 | 0.4 (0.1–1.5) | 0.2 | 0.2 (0.04–1.2) | 0.08 | 0.8 (0.3–2.1) | 0.7 | 0.5 (0.06–5.06) | 0.6 |
 | 80–155 | Ref |  | Ref |  | Ref |  | Ref |  |
 | > 155 | 0.5 (0.1–2.1) | 0.4 | 0.2 (0.02–2.03) | 0.1 | 0.2 (0.07–1.11) | 0.07 | 2.01 (0.3–10.7) | 0.4 |
rs4806660 (TT) | Calcium | TC | CC | TC | CC | ||||
 | 9.5> | 13.7 (0.2–65.6) | 0.1 | 0.07 (0.002-3.4) | 0.1 | 7.8 (0.98–34.3) | 0.9 | 6.8 (0.64–72.8) | 0.1 |
 | 9.5< | Ref | Ref | Ref | Ref | ||||
rs451417 (AA) | Phosphate | CC | CA | CC | CA | ||||
 | 4.5> | 10.5 (0.2–45.7) | 0.2 | 3.2 (0.09–10.8) | 0.5 | 2.02 (0.1–39.3) | 0.6 | 0.4 (0.04–4.2) | 0.4 |
 | 4.5< | Ref | Ref | Ref | Ref |