Table 2 Univariate and multivariate Cox regression model analysis of OS and CCSS
| Â | OS | CCSS | ||||||
|---|---|---|---|---|---|---|---|---|
Characteristics | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
HR (95% CI) | P | HR (95% CI) | P | HR(95% CI) | P | HR(95% CI) | P | |
Marital status | Â | Â | Â | Â | Â | Â | Â | Â |
 Unmarried | 1 |  | 1 |  | 1 |  | 1 |  |
 Married | 0.638(0.614,0.662) | 0.000 | 0.830(0.798, 0.862) | 0.000 | 0.706(0.673, 0.740) | 0.000 | 0.892(0.850, 0.937) | 0.000 |
Year | Â | Â | Â | Â | Â | Â | Â | Â |
 1975–2000 | 1 |  | 1 |  | 1 |  | 1 |  |
 2001–2017 | 0.820(0.786, 0.855) | 0.000 | 0.826 (0.786, 0.869) | 0.000 | 0.849(0.809, 0.892) | 0.000 | 0.797(0.751, 0.846) | 0.000 |
age | Â | Â | Â | Â | Â | Â | Â | Â |
 < 45 | 1 |  | 1 |  | 1 |  | 1 |  |
 45–59 | 2.183(2.076, 2.295) | 0.000 | 1.606 (1.525, 1.691) | 0.000 | 1.683(1.585, 1.786) | 0.000 | 1.089(1.024, 1.158) | 0.007 |
 ≥ 60 | 4.751(4.529, 4.983) | 0.000 | 2.896 (2.751, 3.049) | 0.000 | 2.660(2.512, 2.816) | 0.000 | 1.377(1.295, 1.464) | 0.000 |
Race | Â | Â | Â | Â | Â | Â | Â | Â |
 White | 1 |  | 1 |  | 1 |  | 1 |  |
 Black | 1.407(1.331, 1.489) | 0.000 | 1.187 (1.122, 1.257) | 0.000 | 1.394(1.300, 1.495) | 0.000 | 1.192(1.110, 1.280) | 0.000 |
 Other | 0.879(0.828, 0.932) | 0.000 | 0.825 (0.778, 0.876) | 0.000 | 0.929(0.864, 0.998) | 0.044 | 0.891(0.829, 0.958) | 0.002 |
Histologic type | Â | Â | Â | Â | Â | Â | Â | Â |
 SSC | 1 |  | 1 |  | 1 |  | 1 |  |
 AC | 0.738(0.702, 0.777) | 0.000 | 1.137 (1.078, 1.199) | 0.000 | 0.782(0.734, 0.833) | 0.000 | 1.304(1.220, 1.394) | 0.000 |
 Others | 1.036(0.978, 1.097) | 0.231 | 1.210 (1.141, 1.283) | 0.000 | 1.231(1.151, 1.317) | 0.000 | 1.398(1.304, 1.498) | 0.000 |
Grade | Â | Â | Â | Â | Â | Â | Â | Â |
 Well | 1 |  | 1 |  | 1 |  | 1 |  |
 Moderately | 1.555(1.454, 1.662) | 0.000 | 1.153 (1.076, 1.235) | 0.000 | 1.960(1.781, 2.157) | 0.000 | 1.343(1.218, 1.482) | 0.000 |
 Poorly/Undiff | 2.318(2.172, 2.473) | 0.000 | 1.386 (1.295, 1.484) | 0.000 | 3.257(2.968, 3.574) | 0.000 | 1.716(1.558, 1.890) | 0.000 |
Stage | Â | Â | Â | Â | Â | Â | Â | Â |
 Localized | 1 |  | 1 |  | 1 |  | 1 |  |
 Regional | 3.047(2.920, 3.180) | 0.000 | 1.892 (1.797, 1.991) | 0.000 | 4.517(4.248, 4.803) | 0.000 | 3.062(2.845, 3.295) | 0.000 |
 Distant | 9.461(8.942, 10.009) | 0.000 | 5.715 (5.351, 6.103) | 0.000 | 16.411(15.291, 17.613) | 0.000 | 10.472(9.627, 11.392) | 0.000 |
Regional nodes | Â | Â | Â | Â | Â | Â | Â | Â |
 Negative | 1 |  | 1 |  | 1 |  | 1 |  |
 Positive | 1.155(1.079, 1.237) | 0.000 | 1.037 (0.961, 1.119) | 0.354 | 1.391(1.289, 1.501) | 0.000 | 1.027(0.942, 1.120) | 0.547 |
Surgery | Â | Â | Â | Â | Â | Â | Â | Â |
 No | 1 |  | 1 |  | 1 |  |  |  |
 Yes | 0.266(0.256, 0.276) | 0.000 | 0.496 (0.472, 0.521) | 0.000 | 0.236(0.225, 0.248) | 0.000 | 0.429(0.403, 0.456) | 0.000 |
Radiotherapy | Â | Â | Â | Â | Â | Â | Â | Â |
 No | 1 |  | 1 |  | 1 |  | 1 |  |
 Yes | 2.882(2.760, 3.010) | 0.000 | 1.065 (1.009, 1.125) | 0.023 | 3.122(2.948, 3.305) | 0.000 | 0.964(0.899, 1.034) | 0.310 |
Chemotherapy | Â | Â | Â | Â | Â | Â | Â | Â |
 No | 1 |  | 1 |  | 1 |  | 1 |  |
 Yes | 1.651(1.584, 1.721) | 0.000 | 0.950(0.900, 1.003) | 0.062 | 1.985(1.891, 2.083) | 0.000 | 0.948(0.889, 1.010) | 0.101 |