Table 2 Two-sample MR estimates of relationship between female reproductive factors and female genital prolapse
Exposure | MR Method | Female genital prolapse | Heterogeneity | Horizontal pleiotropy | ||||
|---|---|---|---|---|---|---|---|---|
No. of SNPs | OR (95% CI) | P-Value | Cochran’s Q | P-Value | Egger intercept | P-Value | ||
Age at menarche | IVW | 6 | 0.824 (0.707–0.961) | 0.014 | 1.723 | 0.885 | -0.012 | 0.766 |
MR-Egger | 0.925 (0.447–1.913) | 0.844 | ||||||
WM | 0.823 (0.675–1.004) | 0.054 | ||||||
Simple mode | 0.871 (0.665–1.142) | 0.364 | ||||||
Weighted mode | 0.809 (0.637–1.026) | 0.141 | ||||||
Age at menopause | IVW | 38 | 1.002 (0.957–1.048) | 0.945 | 63.447 | 0.004 | -0.002 | 0.896 |
MR-Egger | 1.009 (0.892–1.142) | 0.883 | ||||||
WM | 1.005 (0.950–1.063) | 0.857 | ||||||
Simple mode | 0.988 (0.893–1.094) | 0.821 | ||||||
Weighted mode | 1.001 (0.933–1.073) | 0.986 | ||||||
Age at first birth | IVW | 55 | 0.846 (0.759–0.943) | 0.003 | 115.379 | 2.392e-06 | 0.007 | 0.717 |
MR-Egger | 0.770 (0.459–1.293) | 0.327 | ||||||
WM | 0.854 (0.758–0.962) | 0.010 | ||||||
Simple mode | 0.738 (0.542–1.005) | 0.059 | ||||||
Weighted mode | 0.762 (0.588–0.989) | 0.046 | ||||||
Age at last live birth | IVW | 4 | 0.621 (0.303–1.272) | 0.193 | 1.670 | 0.644 | 0.072 | 0.445 |
MR-Egger | 0.038 (0.000–13.374) | 0.388 | ||||||
WM | 0.711 (0.288–1.759) | 0.461 | ||||||
Simple mode | 0.766 (0.216–2.711) | 0.707 | ||||||
Weighted mode | 0.748 (0.216–2.594) | 0.678 | ||||||
Age at first sexual intercourse | IVW | 154 | 0.710 (0.575–0.878) | 0.002 | 161.365 | 0.306 | 0.004 | 0.622 |
MR-Egger | 0.567 (0.226–1.422) | 0.228 | ||||||
WM | 0.665 (0.487–0.908) | 0.010 | ||||||
Simple mode | 0.650 (0.240–1.763) | 0.399 | ||||||
Weighted mode | 0.706 (0.298–1.670) | 0.429 | ||||||