Table 3 Two-sample MR estimates of relationship between female reproductive factors and Stress urinary incontinence
Exposure | MR Method | Female genital prolapse | Heterogeneity | Horizontal pleiotropy | ||||
|---|---|---|---|---|---|---|---|---|
No. of SNPs | OR (95% CI) | P-Value | Cochran’s Q | P-Value | Egger intercept | P-Value | ||
Age at menarche | IVW | 5 | 0.999 (0.997–1.001) | 0.462 | 4.057 | 0.398 | 1.069e-04 | 0.856 |
MR-Egger | 0.998 (0.989–1.008) | 0.760 | ||||||
WM | 1.000 (0.997–1.002) | 0.779 | ||||||
Simple mode | 1.001 (0.997–1.005) | 0.613 | ||||||
Weighted mode | 1.001 (0.998–1.004) | 0.554 | ||||||
Age at menopause | IVW | 37 | 1.000 (0.999–1.001) | 0.484 | 70.584 | 0.501e-03 | 1.287e-04 | 0.418 |
MR-Egger | 0.999 (0.998–1.001) | 0.588 | ||||||
WM | 1.000 (0.999–1.001) | 0.365 | ||||||
Simple mode | 1.001 (0.999–1.002) | 0.113 | ||||||
Weighted mode | 1.001 (1.000–1.001) | 0.189 | ||||||
Age at first birth | IVW | 54 | 0.998 (0.997–0.999) | 7.659e-05 | 71.058 | 0.049 | 3.223e-05 | 0.869 |
MR-Egger | 0.998 (0.992–1.003) | 0.372 | ||||||
WM | 0.998 (0.997–0.999) | 0.004 | ||||||
Simple mode | 0.998 (0.995–1.001) | 0.189 | ||||||
Weighted mode | 0.997 (0.994–0.999) | 0.032 | ||||||
Age at last live birth | IVW | 4 | 0.993 (0.985–1.001) | 0.071 | 2.268 | 0.519 | 0.001 | 0.286 |
MR-Egger | 0.946 (0.886–1.010) | 0.240 | ||||||
WM | 0.995 (0.985–1.001) | 0.358 | ||||||
Simple mode | 0.996 (0.980–1.013) | 0.683 | ||||||
Weighted mode | 0.996 (0.982–1.011) | 0.655 | ||||||
Age at first sexual intercourse | IVW | 145 | 0.994 (0.991–0.997) | 8.716e-05 | 216.998 | 8.082e-05 | 1.427e-04 | 0.178 |
MR-Egger | 0.985 (0.972–0.999) | 0.035 | ||||||
WM | 0.994 (0.990–0.997) | 4.820e-04 | ||||||
Simple mode | 0.996 (0.985–1.007) | 0.418 | ||||||
Weighted mode | 0.994 (0.985–1.004) | 0.224 | ||||||