The causal effect of reproductive factors on pelvic floor dysfunction: a Mendelian randomization study

BMC Women's Health

Table 4 MVMR estimates of relationship between female reproductive factors and Pelvic floor dysfunction

Exposure	MR Method	Female genital prolapse			Stress urinary incontinence
Exposure	MR Method	No. of SNPs	OR (95% CI)	P-Value	No. of SNPs	OR (95% CI)	P-Value
Age at menarche	IVW	3	0.920 (0.793–1.069)	0.276	3	1.000 (0.999–1.002)	0.706
Age at menopause		67	1.098 (0.958–1.258)	0.180	59	1.001 (0.999–1.002)	0.339
Age at first birth		29	0.756 (0.610–0.936)	0.010	28	0.999 (0.997–1.002)	0.620
Age at last live birth		2	1.376 (0.591–3.204)	0.460	2	1.000 (0.990–1.009)	0.923
Age at first sexual intercourse		101	1.171 (0.733–1.872)	0.509	97	0.994 (0.989–0.999)	0.032

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