A cross-sectional study observing the association of psychosocial stress and dietary intake with gut microbiota genera and alpha diversity among a young adult cohort of black and white women in Birmingham, Alabama

Knight, Rachel O.; Cedillo, Yenni E.; Judd, Suzanne E.; Baker, Elizabeth H.; Frugé, Andrew D.; Moellering, Douglas R.

doi:10.1186/s12905-024-02968-6

Table 3 Mediation Analysis: Psychosocial Stress, Diet, and the Gut Microbiota

From: A cross-sectional study observing the association of psychosocial stress and dietary intake with gut microbiota genera and alpha diversity among a young adult cohort of black and white women in Birmingham, Alabama

X	Mediator	Y	Path a		Path b		Path c’		Path c
X	Mediator	Y	b	p-value	b	p-value	b	p-value	Adj R	p-value
RED	Fiber	Alistipes	−0.642	0.103	−0.0001	0.389	0.001	0.029	0.093	0.065
RED	DIS	Alistipes	0.132	0.054	0.001	0.198	0.001	0.029	0.116	0.041
RED	HEI	Alistipes	−0.074	0.803	−0.0000	0.993	0.001	0.029	0.074	0.095
RED	SC	Alistipes	0.002	0.604	0.028	0.126	0.001	0.024	0.134	0.024
LED	Fiber	Alistipes	−0.391	0.514	−0.000	0.285	0.001	0.026	0.104	0.049
LED	DIS	Alistipes	0.058	0.572	0.001	0.138	0.001	0.026	0.130	0.029
LED	HEI	Alistipes	0.119	0.799	0.000	0.943	0.001	0.026	0.076	0.087
LED	HC	Alistipes	0.008	0.341	0.011	0.172	0.001	0.133	0.057	0.127
RED	Fiber	Blautia	−0.650	0.115	−0.0003	0.570	−0.003	0.054	0.059	0.136
RED	DIS	Blautia	0.111	0.116	−0.002	0.594	−0.003	0.054	0.057	0.139
RED	HEI	Blautia	0.057	0.849	−0.0002	0.757	−0.003	0.054	0.052	0.152
RED	SC	Blautia	0.002	0.450	−0.042	0.593	−0.003	0.019	0.101	0.056
LED	Fiber	Blautia	−0.391	0.514	0.0004	0.608	−0.003	0.215	−0.005	0.410
LED	DIS	Blautia	0.058	0.572	−0.003	0.566	−0.003	0.215	−0.003	0.340
LED	HEI	Blautia	0.119	0.799	−0.001	0.599	−0.003	0.215	−0.004	0.408
LED	HC	Blautia	0.006	0.431	−0.081	0.178	−0.004	0.183	0.041	0.167
LED	Fiber	ASV	−0.276	0.499	0.024	0.927	−1.188	0.110	0.012	0.282
LED	DIS	ASV	0.006	0.933	−1.234	0.375	−1.188	0.110	0.028	0.191
LED	HEI	ASV	0.014	0.967	0.333	0.298	−1.188	0.110	0.034	0.164
LED	HC	ASV	0.005	0.260	−4.260	0.866	−1.426	0.104	0.013	0.265
LED	Sugar	ASV	0.319	0.492	−0.119	0.606	−1.188	0.110	0.017	0.248
PSSUM	Fiber	ASV	−0.571	0.035	−0.164	0.595	−1.04	0.077	0.028	0.185
PSSUM	DIS	ASV	0.169	0.001	−0.649	0.717	−1.04	0.077	0.025	0.200
PSSUM	HEI	ASV	−0.782	0.000	0.284	0.490	−1.04	0.077	0.032	0.168
PSSUM	Sugar	ASV	0.617	0.063	−0.289	0.248	−1.04	0.077	0.048	0.109

RED recent experiences of discrimination, LED lifetime experiences of discrimination, PSSUM perceived stress score, DIS dietary inflammation score, HEI healthy eating index, SC salivary cortisol, HC hair cortisol, ASV amplicon sequence variant
Path a: The effect of X on the mediator
Path b: The effect of the mediator on Y
Path c’: The direct effect of X on Y, controlled for the mediator. (Both X and mediator are predictor variables)
Path c: The total effect of X on Y

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ISSN: 1472-6874

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