Table 2 Changes in mammographic and MRI characteristics after NAC according to subtype
|  | HR+ HER2− (n = 90) | HR− HER2− (n = 51) | HR+ HER2+ (n = 81) | HR− HER2+ (n = 101) | P value |
|---|---|---|---|---|---|
Post-NAC tumor size (invasive), mm | 25.0 (12.0, 50.0) | 19.5 (6.3, 33.5) | 13.0 (3.3, 25.0) | 14.0 (3.3, 25.0) | 0.004 |
Post-NAC tumor size (in situ), mm | 30.0 (11.5, 60.0) | 25.0 (7.0, 40.0) | 20.0 (5.3, 46.5) | 25.0 (6.0, 43.5) | 0.346 |
Post-NAC extent of microcalcifications, mm | 44.0 (27.0, 71.0) | 23.5 (13.3, 35.8) | 41.0 (20.5, 70.0) | 48.0 (28.8, 70.3) | 0.003 |
Changes in extent of microcalcifications | Â | Â | Â | Â | 0.147 |
 No change | 60 (66.7) | 31 (60.8) | 50 (61.7) | 67 (66.3) |  |
 Decreased | 18 (20.0) | 8 (15.7) | 19 (23.5) | 25 (24.8) |  |
 Increased | 5 (5.6) | 2 (3.9) | 6 (7.4) | 4 (4.0) |  |
 New | 2 (2.2) | 2 (3.9) | 1 (1.2) | 4 (4.0) |  |
 Not specified | 5 (5.6) | 8 (15.7) | 5 (6.2) | 1 (1.0) |  |
Change in morphology of microcalcifications |  |  |  |  |  < 0.001 |
 No change | 46 (51.1) | 18 (35.3) | 35 (43.2) | 51 (50.5) |  |
 Change | 14 (15.6) | 1 (2.0) | 20 (24.7) | 22 (21.8) |  |
 Not specified | 30 (33.3) | 32 (62.7) | 26 (32.1) | 28 (27.7) |  |
Radiologic response of breast cancer on MRI | Â | Â | Â | Â | 0.073 |
 CR | 11 (12.2) | 10 (19.6) | 26 (32.1) | 27 (26.7) |  |
 Non-CR | 78 (86.7) | 41 (80.4) | 54 (66.7) | 73 (72.3) |  |
 Not specified | 1 (1.1) | 0 (0.0) | 1 (1.2) | 1 (1.0) |  |
Pathologic response of breast cancer |  |  |  |  |  < 0.001 |
 pCR | 10 (11.1) | 16 (31.4) | 33 (40.7) | 43 (42.6) |  |
 Non-pCR | 80 (88.9) | 35 (68.6) | 48 (59.3) | 58 (57.4) |  |