Table 3 Univariate and multivariate analyses of local recurrence

Age at diagnosis, years (ref =  < 40)

  ≥ 40

0.712 (0.350–1.530)

0.363

Clinical T stage before NAC (ref = cT1)

 cT2-4

1.387 (0.250- 25.810)

0.758

Clinical N stage before NAC (ref = cT0)

 cN1-3

1.232 (0.340–7.950)

0.785

Lymphovascular invasion (ref = absent)

 Present

6.416 (3.110- 14.090)

 < 0.001

5.950 (2.430–16.130)

 < 0.001

HR + (ref = negative)

 Positive

0.459 (0.220–0.910)

0.028

0.490 (0.170–1.300)

0.159

HER2⁺(ref = negative)

 Positive

0.462 (0.210- 0.970)

0.046

0.340 (0.130- 0.860)

0.026

Ki-67 before NAC (ref =  < 14%)

  ≥ 14%

1.728 (0.580- 7.430)

0.383

Ki-67 after NAC (ref =  < 14%)

  ≥ 14%

4.810 (2.090- 12.500)

 < 0.001

5.010 (1.760- 16.120)

0.004

Radiologic response of MRI (ref = CR)

 Non-CR

6.283 (1.860–39.240)

0.013

N/A

0.988

Extent of surgery (ref = total mastectomy)

 Partial mastectomy

0.661 (0.330–1.300)

0.237

Pre-NAC extent of microcalcifications, mm (ref =  < 10)

  ≥ 10

0.500 (0.120–3.440)

0.397

Post-NAC extent of microcalcifications, mm (ref =  < 10)

  ≥ 10

0.590 (0.140- 3.990)

0.512

Residual microcalcification (ref = absent)

 Present

1.119 (0.364–2.839)

0.827

1.740 (0.410–6.410)

0.423