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Table 3 Antihypertensive medications use and risk of ovarian cancer mortality: lag time analyses

From: Evaluation of antihypertensive medications use and survival in patients with ovarian cancer: a population-based retrospective cohort study

Antihypertensive medications use

 

Follow-up excluding first 2 years after diagnosis

HR (95% CI)a

Deaths/ Cases, n

HR (95% CI)a

SNS-AH

   

 Non-use

1.00

156/467

1.00

 Use

1.05 (0.61; 1.80)

18/43

1.10 (0.58; 2.10)

Diuretics

   

 Non-use

1.00

134/410

1.00

 Use

1.03 (0.68; 1.56)

40/100

1.01 (0.62; 1.65)

Beta blockers

  

 Non-use

1.00

116/366

1.00

 Use

1.43 (0.98; 2.08)

58/144

1.47 (0.94; 2.29)

Calcium channel blockers

  

 Non-use

1.00

153/446

1.00

 Use

0.75 (0.45; 1.23)

21/64

0.78 (0.44; 1.40)

Angiotensin receptor blockers

  

 Non-use

1.00

160/461

1.00

 Use

0.73 (0.43; 1.23)

14/49

0.55 (0.29; 1.04)

ACE inhibitors

  

 Non-use

1.00

131/380

1.00

 Use

0.55 (0.36; 0.83)

43/130

0.58 (0.37; 0.93)

  1. aCox model, adjusted for age, place of residence, CCI, stage, histology, surgery, chemotherapy, radiotherapy, use of anticoagulants, statins, antidiabetics, antihypertensive medications 1-year prior to diagnosis. Mutually adjusted for the use of antihypertensive medications 1-year after diagnosis