- Study protocol
- Open Access
- Open Peer Review
This article has Open Peer Review reports available.
Integrative health care model for climacteric stage women: design of the intervention
© Doubova et al; licensee BioMed Central Ltd. 2011
Received: 30 November 2010
Accepted: 20 February 2011
Published: 20 February 2011
Climacteric stage women experience significant biological, psychological and social changes. With demographic changes being observed in the growing number of climacteric stage women in Mexico, it is important to improve their knowledge about the climacteric stage and its potential associated problems, encourage their participation in screening programs, and promote the acquisition of healthy lifestyles.
At Mexican health care institutions the predominant health care model for climacteric stage women has a biomedical perspective. Medical doctors provide mostly curative services and have limited support from other health professionals. This study aims to design an integrative health care model (IHCM: bio-psycho-social, multidisciplinary and women-centered) applicable in primary care services aimed at climacteric stage women.
We present the design, inclusion criteria and detailed description of an IHCM. The IHCM consists of collaborative and coordinated provision of services by a health team, which is involves a family doctor, nurse, psychologist, and the woman herself. The health team promotes the empowerment of women through individual and group counseling on the climacteric stage and health related self-care. The intervention lasts three months followed by a three-month follow-up period to evaluate the effectiveness of the model. The effectiveness of the model will be evaluated through the following aspects: health-related quality of life (HR-QoL), empowerment, self-efficacy and knowledge regarding the climacteric stage and health-related self-care activities, use of screening services, and improvement in lifestyles (regular leisure time physical activity and healthy diet).
Participation in preventive activities should be encouraged among women in Mexico. Designing and evaluating the effectiveness of an integrative health care model for women at the climacteric stage, based on the empowerment approach and focus on health-related self-care to improve their HR-QoL is pertinent for current health conditions of this age group.
The study is registered at the ClinicalTrials.gov (NCT01272115).
The climacteric stage is the transition from the reproductive to the non-reproductive period during a woman's life , and comprises 2 to 8 years before and after menopause , and coincides with a complex period in life due to biological, psychological and social changes.
Two circumstances motivated the design of this study. One is related to the unfelt and unsatisfied health needs of climacteric stage women; the other is related to the existing supply of health services in Mexico to the care of women at this stage.
Health needs and existing supply of health services in Mexico for climacteric stage women
A need arises when one sees a difference between the situation considered as optimal and the actual observed situation; the difference to be reduced is then the need. In the health field, the felt need relates to the perception people have about their health problems or whatever they want to receive from the health services. Unlike a need that is not felt, there exists a need that people do not perceive, but it must be satisfied to maintain, restore or improve their health .
Increase in life expectancy has also caused an increase in the proportion of climacteric stage women with respect to the general population. Traditionally, climacteric stage women seek medical attention when they perceive health problems attributed to this stage such as severe climacteric symptoms, osteoporosis-related fractures, symptoms and/or complications of chronic diseases. Regarding the unfelt and unsatisfied need, most women do not perceive the need to prevent or detect such health problems early. These situations result in delayed health seeking-behavior for these problems, which in turn represent a significant burden for health care systems and for the society due to the high costs of health care, decreased quality of life and premature death [4–6].
In Mexico, a high proportion of women in the climacteric stage experience important biological, psychological and social changes; 50-70% report climacteric symptoms [7, 8], 45.6% depression and other mood and sleep disorders , 31.1% suffer from hypertension, 16.7% suffer from diabetes [10, 11]; the prevalence of hip fractures secondary to osteoporosis is 169 per 10,000 women-years , of breast cancer is 27.4 per 100,000 woman-years, and of cervical cancer is 19.2 per 100,000 woman-years . This situation is worsened by women's overall limited knowledge about the potential health problems associated with the climacteric stage, and about the necessary preventive measures, indicated by their low participation in screening programs for chronic diseases and their unhealthy lifestyles (high proportion of physical inactivity and low consumption of fruits, vegetables and foods rich in calcium [8, 11, 14]), which impede a better overall health and quality of life.
Regarding the existing supply of health care for climacteric stage women (how the need is being met), Mexico has a fragmented health system, composed by Social Security institutions, the Ministry of Health (MoH) and private providers. The Mexican Institute of Social Security (IMSS) is a nation-wide social security institution that provides health and social services as well as economic benefits to formal sector workers and their families (approximately 48 million). While the MoH is central authority in charge of the policies and design of programs and while the provision of care is decentralized through the MoH in the 32 states, while granting each a certain autonomy, MoH provides health care to people without social security, mostly through the System for Social Protection of Health .
Despite the existence of preventive programs, most health care for climacteric women is based on a biomedical model in which a curative perspective predominates without support or with very limited support from other health professionals, where the relationship between health providers and patients is usually justified by authoritative professional knowledge. This model gives more importance to medical care for biological symptoms and minimizes the relevance of the psychogical and social changes that happen during the climacteric period.
Interventions targeted at climacteric stage women
Most interventions for climacteric stage women have focused on informing/educating women about preventing certain diseases. Some studies have developed educational strategies to prevent osteoporosis  or to improve healthy diet , and have also aimed to improve physical activity in menopausal women, demonstrating the feasibility and effectiveness of moderate and rigorous physical activity, which in turn improves muscle strength, blood pressure, bone density and health-related quality of life (HR-QoL) [18–20]. Other studies have examined the impact of information about healthy behaviors, stress management and possible treatments during the climacteric stage; these studies have reported the favorable effect of education groups on the participants' knowledge, which is manifested by perceived ease in dealing with the changes of this stage, increase of healthy habits and increased sexual interest, when compared with a control group [21, 22]. In climacteric women, as in the general population, interventions that incorporate cognitive-behavioral strategies, such as individual and group counseling to facilitate changes in lifestyle, have greater positive effect on vasomotor symptoms, psychological distress, self-efficacy, satisfaction with care and cardiovascular risk factors when compared to printed or verbal information [23–28].
Integrative health care model and the empowerment approach
In the 1980 s, the biomedical model was strongly criticized in the middle of severe economic crises in many countries including Mexico. Alternative models that integrated biological, psychological and social areas gained momentum . In 1994, M. Flint , highlighted the relationship among the biological, social and psychological factors that women face during menopause, highlighting the need for women to receive bio-psycho-social care at this stage.
The integrative health care model (IHCM)  includes a multidisciplinary approach based on a non-hierarchical combination of conventional medicine with complementary and alternative medicine, which promotes the harmonious continuity in decision-making and care that should be focused on the patient. The IHCM is based on a specific set of core values that include the goal of addressing health care in a holistic manner, and promoting personal health and wellbeing. The multidisciplinary approach of the IHCM is based on the collaborative participation of health team members, their mutual respect and a shared vision between them and the patients. This circumstance allows each provider and each patient to contribute their knowledge and particular skills to focus on providing health care to persons within individual care plans. In the experimental field in both developed and developing countries, attempts to implement the IHCM have been made. The study results showed that the IHCM allowed increased use of preventive services, improved health education and health outcomes [32, 33]. The integrative care model is consistent with the empowerment approach. Empowerment is the social process of recognizing, promoting and enhancing the capacity of people to meet their needs, solve their problems, and mobilize the resources needed to take control of their lives . The goal of patient empowerment is to build the patients' capacity for self-care, facilitate the process of obtaining experiences to identify problems (health needs), set goals related to their own health care, identify personal and social obstacles, develop solutions, consider the possible consequences of alternative solutions and make appropriate decisions for themselves [35–37]. The empowerment approach is linked to the theory of self-determination which supports the empowering of patients to be more independent in their self-care, and raising the possibility of long-lasting changes in health-related behaviors . The counseling focused on the problems perceived and prioritized by the individual considers empowerment as an approach that also includes cultural aspects.
Interventions aimed to potentiate individual (or social) resources to prevent health damage or solve health problems implicitly adopt an empowerment approach to enable people to improve their quality of life by increasing the power to control their problems. For example, it has been shown that individual and group counseling on health-related self-care of patients with chronic diseases based on the empowerment principles, taking their cultural characteristics into account, achieved positive effects on HR-QoL, knowledge about the disease and related self-care, satisfaction with care and metabolic control compared with the control group (telephone counseling on metabolic control and traditional education) [39, 40]. In addition, patients empowered in health-related self-care used fewer medical appointments, resulting in significant savings for health services .
Conceptual model and objectives of the study
Structure and population characteristics of health institutions in Mexico
Mexican Institute of Social Security
Ministry of Health
Formal sector workers and their families
People without formal employment contracts, or unemployed and the rural population
Drug acquisition, laboratory and screening tests
Covered by the social insurance
Covered partially by the insurance + out of pocket payments
1.4 per 1000 habitants
1.3 per 1000 habitants
2.0 per 1000 habitants
1.7 per 1000 habitants
A field trial with one intervention and one comparison group, with ex ante and ex post measurements will be conducted in two IMSS primary care clinics in Mexico City. The clinics will be selected for convenience; each clinic must have more than 20 family doctors' offices and available space for the intervention (consulting room and an area for group counseling) and should have accepted to participate in the study; The intervention will be conducted in one clinic and the other clinic will serve as a comparison group, where the usual care for climacteric stage women will be observed.
The study population will consist of women affiliated with IMSS, between 45 and 59 years of age with a maximum of 5 years after menopause. The women should be users of the clinic, and should not have mental conditions that would prevent them from understanding the information or from taking independent decisions (dementia, mental retardation or psychosis), a physical disability that would impede them from participating (hearing loss, diseases affecting physical mobility as severe forms of rheumatoid arthritis), medical diagnosis of depression, diabetes mellitus, hypertension, renal or liver failure, and/or cancer, because patients with these diseases require specific care provided by several specialists. All women must agree to participate in the study through written informed consent.
The project was authorized by the National Research and Ethics Committee of the IMSS.
Preparation of the intervention
In both intervention and control clinics the project will be presented to healthcare providers.
A healthcare team will implement the intervention comprised of family doctors, two nurses (one for each working shift) and a psychologist. The nurses and the psychologist will be selected from those with clinical experience in providing care to climacteric stage women; they will be previously trained by researchers and will work specifically in this project. The training will include theory and practice, and will last 60 hours based on a "training guide" that was developed ex profeso. The training topics include: 1) Health needs of climacteric stage women; 2) Risk factors for chronic diseases during the climacteric stage and self-care-related activities; 3) Health behaviors, self-efficacy, knowledge regarding climacteric stage and health-related self-care activities and empowerment; 4) Cognitive restructuring and problem solving, self-esteem and communication; 5) Healthy diet enriched with fruits, vegetables and milk products; 6) Regular leisure time with physical activity; 7) Individual counseling from the empowerment approach. Self-care plan: goal setting, action planning, monitoring and achievement of health goals; 8) Group counseling from the empowerment; 9) Integrative health care model for women at the climacteric stage.
All family doctors working in the intervention clinic will be invited to participate in the study. Family doctors, who agree to collaborate, will participate in a training course that consists in reviewing and discussing the proposed model, the roles and responsibilities of health providers involved in the care of climacteric stage women within IHCM. The researchers will deliver this course that will last two sessions of 60 minutes each.
Description of the intervention
The IHCM with an empowerment approach will address the care that should be given collaboratively by the health team in cooperation with the active participation of women. The IHCM will be provided under the leadership of the nurse who will coordinate with the health team members, promote preventive care, and incorporate cognitive-behavioral strategies, such as individual and group counseling. The IHCM will be provided for three months to each woman, followed by a three-month follow-up. The empowerment of women will work to facilitate women's recognition of their actual or potential health problems, enable them to solve these problems by drawing up an action plan to improve or maintain their health, and develop their autonomous health-related self-care skills.
In the control group, women will continue the usual healthcare consisting of curative care provided by their family doctor and preventive care according to the IMSS prevention programs focused on this age group (chronic disease screening) and provided by nurses according to the women's demand.
Recruitment of women and consultation with the family doctor
In both working shifts (morning and afternoon) family doctors will identify and evaluate those women who meet the inclusion criteria. Family doctors should provide preventive and curative healthcare services, according to womens' individual health needs, and send the candidates to the waiting room where they will be interviewed by study interviewers, who will explain the purpose and content of the study, and obtain the signed informed consent from those women who agree to participate. Once the participant is included in the study, the interviewer will perform the base-line interview then send the woman to the nurse of the study.
Individual counseling by nurse
Individual counseling for climacteric stage women
1) Evaluation of the current status of women (physical, emotional, cognitive, etc.) within their social environment
• The nurse and the woman collaboratively assess the woman's health and health-related self-care practices (diet, leisure time physical activity, use of screening services).
• The nurse provides relevant information on climacteric self-care: a) explains the definition of the climacteric stage and menopause and health problems the woman may experience during and after the climacteric stage; b) describe the factors (activities) that cause or protect against the occurrence of such problems; c) answers the woman's questions.
2) Facilitation of the woman's recognition of her personal health risks and responsibility for health-related self-care
• The nurse guides women on specific personal health-related values, beginning with the question: What health would you like to have in the next 10 years?
3 and 4) Guidance on the health-related goal setting and elaboration of a feasible action plan for women's self-care
• The nurse guides women to choose their personal health-related self-care goals.
• The nurse guides women to choose strategies/actions to overcome barriers, using the problem-solving model.
• The nurse facilitates the agreement of women to carry out the action plan.
• The nurse and women jointly assess the level of womens' self-efficacy regarding the achievement of the agreed actions (on a scale of 0 to 10).
5) Monitoring of the progress of the action plan
The nurse and women jointly:
• Evaluate progress in achieving the health-related goals and specific actions for development and maintenance of healthy behaviors.
• Resolve problems related to barriers for implementing the action plan, translating such barriers in the "learned lessons."
The nurse will also schedule appointments for individual and group counseling and refer the woman to the psychologist and to the family doctor, who will provide comprehensive and continuous care consistent with the personal health needs of each participant.
Individual counseling by the psychologist
Psychological counseling will be based on the Rational Emotive Behavioral Therapy and its central concept ABC . According to this concept, emotional and behavioral consequences (C) are the result of beliefs (B) on activating events (A). The psychologist and the woman will collaboratively evaluate and restructure the woman's erroneous beliefs about the climacteric stage and her emotional resources, which refer to the ability to positively guide the emotions to achieve a better level of self-esteem and self-efficacy. The psychologist and the woman will define the number of consultations required in accordance to her individual needs and characteristics.
All women of the intervention group will be invited to eight weekly, 90-minutes group sessions to facilitate and enhance their knowledge about menopause and their care, as well as to share experiences, concerns and motivations, with other women. Each group session will be coordinated by the nurse or psychologist of the study and will include five to ten women. The group sessions will focus on common educational needs. Both individual and group counseling will be supported by printed material developed ex profeso, which participants will be encouraged to keep as a source of information.
The main themes of group sessions will be: 1) the climacteric stage and the empowerment approach; 2) Emotional well-being, self-esteem and self-efficacy during menopause; 3) Factors that predispose chronic disease development during the climacteric stage and health-related self-care strategies; 4) Physical activity: barriers, benefits, type, frequency and recommended time. How to establish an individual action plan on physical activity and make it feasible (problem solving); 5) Healthy diet during the climacteric stage including increase of intake of fruits, vegetables and dairy products on a daily basis, as well as education about the barriers to and benefits of a healthy diet. How to establish an individual action plan toward a healthy diet and make it feasible; 6-8) Monitoring of the progress of women's action plans. Participants should attend to group sessions one to five, and to sessions six to eight can attend either as a group or individually.
Information on the study variables will be collected on three occasions: when the woman enters to the study (baseline), once intervention is complete (at three months) and after three more months of follow-up (six months).
The main outcome variables will be:
Health-related quality of life (HR-QoL), which will be measured with the revised version of Women's Health Questionnaire (WHQ23) . This is a specific questionnaire for women in perimenopause, menopause and post menopause stages, that comprises six domains: anxiety/depression, well-being, somatic symptoms, memory/concentration, vasomotor symptoms and sleep problems. The WHQ23 also has two optional domains: sexual behavior and menstrual symptoms, which will apply only to women who are sexually active or who have menstrual periods. The highest value for each domain score is 100, which means high HR-QoL, and the lowest is 0, which means low HR-QoL.
Other outcome variables will be:
1) Empowerment of women in relation to their self-care measured by the empowerment scale, which was modified from the diabetes empowerment short scale  to be used in climacteric women. The maximum score of empowerment is 5, the minimum is 1.
2) Self-efficacy of women in relation to menopause and its care will be assessed with Perimenopausal Health Self-efficacy Scale (PHS-ES) which consists of 23 items . The maximum score of PHS-ES is 207 (high self-efficacy) and the minimum is 23 (low self-efficacy).
3) Women's knowledge about the climacteric stage will be estimated with a questionnaire developed ex profeso. The questionnaire consists of 24 items that assess the following aspects: what is the climacteric stage, what are climacteric symptoms and health risks, and how can they be prevented during the climacteric stage. The minimum score on the scale corresponds to -24 points (without knowledge) and the maximum 24 points (full knowledge).
4) The use of screening services for: a) breast cancer by mammography in the last two years; b) cervical cancer by Pap-test in the last three years in women without a history of total hysterectomy; c) diabetes by measuring fasting plasma glucose in the last three years; d) hypertension: by measuring the systolic and diastolic blood pressure in the last year. The use of screening services will be estimated as the sum of the number of screening services that women used, divided by the total number of screening services recommended according to IMSS regulations and multiplied by 100.
5) Percentage of women who practice regular leisure time physical activity (PA), where regular was defined as moderate intensity if done for ≥150 minutes/week or vigorous intensity if done ≥75 minutes/week.
6) Percentage of women who practice a healthy diet, which included the daily consumption of fruits (3-4 servings), vegetables (4-5 servings), and dairy products (2-3 servings).
The covariates will be:
a) Women's general characteristics: Age, schooling, marital and employment status.
b) Smoking status and alcohol consumption. Smoking status will consider former and current smokers and will register the number of cigarettes actually smoked per day. Alcohol consumption will be classified as non-drinkers (never drink alcohol), occasional drinkers (drink rarely or less than once a week), moderate drinkers (from 1 to 14 drinks per week) and heavy drinkers (more than 14 drinks per week).
c) Nutritional status will be measured by body mass index (BMI) and classified into groups of normal weight (BMI of 18.5-24.9 kg/m2), overweight (BMI of 25.0 to 29.9 kg/m2), or obese (BMI ≥30.0 kg/m2).
d) Social support (SS) will be measured by applying the DUKE-UNC-11 questionnaire . This questionnaire evaluates confidential SS (possibility of having people to communicate with) with a minimum score of 7 points (low confidential SS) and a maximum score of 35 points (high confidential SS); and affective SS (demonstration of love, affection, and empathy) with a minimum score of 4 (low affective SS) and a maximum score of 20 points (high affective SS).
e) Medical and reproductive history: Presence of chronic diseases, number of pregnancies and living children, and menopause (one year after the last menstrual period). Type of menopause will be classified as natural or surgical, age at onset of menopause; time elapsed since menopause, presence and type of climacteric symptoms, and number of visits with the family doctor or other health provider in the last three months. The severity of vasomotor symptoms and vaginal atrophy symptoms is classified using the criteria proposed by the Department of Health and Human Services Food and Drug Administration , which are based upon women's self-report, and define the symptoms as mild, moderate, or severe.
f) Satisfaction with care received at the FMC will be measured with the general question of how satisfied are you with the care you have received at the clinic? The possible answers are very satisfied, satisfied, neither satisfied nor unsatisfied, unsatisfied, and very unsatisfied.
g) Women's self-esteem will be measured with the Rosenberg Self-Esteem Scale (EAR) [48, 49]. It is a one-domain instrument that consists of 10 questions. The highest score is 30 (high self-esteem) and the lowest is 0 (low self-esteem).
h) Adherence to MAIMC will be defined when the woman attends at least 60% of the planned individual and group counseling sessions.
The sample size for the primary outcome (HR-QoL) was estimated by using the formula to test change in the mean of two normally distributed samples in longitudinal studies . An average increase of at least 10 points in one or more domains of WHQ23 in the intervention group compared with control group women was considered to be clinically relevant. The assumptions included: a mean HR-QoL score of 64.9 points (standard deviation of 23.4 points) in the domain of general well-being , α = 0.05 (for one-sided hypothesis) and β = 0.20. The number of women by group, assuming a drop-out rate of 20% will be 107.
We also estimated a sample size for regular leisure time physical activity considering that this is the outcome variable more difficult to achieve. It was assumed that only 17% of women in Mexico engaged in some type of regular leisure time physical activity  and a positive increase of at least 10% will be achieved after women participation in the IHCM. For this calculation, we used the formula to test the difference of proportions between two populations  with a = 0.05 (one side) and the power of 80%. The total number of women by group to include assuming a drop-out rate of 20% will be 207.
The women characteristics of each intervention and comparison groups will be compared by using the Chi-square test to ascertain whether the groups were equivalent.
The effects of intervention for categorical outcome variables (regular leisure time physical activity, healthy diet) will be measured by comparing the baseline and post-intervention evaluation stages for differences in these variables using Chi-square test. Absolute percentage differences and corresponding 95% confidence intervals will be calculated.
Scores for the HR-QoL on the WHQ23 scale, the self-efficacy on the PHS-ES scale, the empowerment on the short form scale, knowledge about the climacteric stage, and menopause and self-care-related activities will be calculated according to the scoring algorithms. Measures of central tendency and distribution will be examined for these variables at the different measurement periods. The differences in the baseline and post-intervention stages for outcome variables will be compared within each group, and differences between the groups will be compared using the differences-in-differences (D-in-D) estimator . The generalized linear model (GLM) will be used to assess changes in the main outcome variable controlling for baseline measures and other study variables as covariates. The GLM methods allow for modeling the correlation of the repeated observations on the same subjects .
The p value <0.05 will be considered as statistically significant. The analysis will be performed with the Stata 11.0 statistical software (Stata 11.0, Stata Corp; College Station, TX).
In primary care services, it is essential to provide a source of care that has continuity and coordination, and comprehensively covers the health needs of people. The constraints resulting from limited resources and restrictive organizational characteristics of institutionalized healthcare allows a limited range of changes, and these circumstances promote that innovative healthcare models should be carefully designed and evaluated to demonstrate healthcare service relevance and feasibility. Relevance, in this case, refers to meeting the health needs of climacteric stage women and to demonstrating its potential benefit. Feasibility means that the new model of care is applicable in the local context. An integrative health care model (bio-psycho-social, multidisciplinary and women-centered) with the empowerment approach may be a better alternative to ensure that women engage in their self-care and understand its importance to their present and future health and quality of life. The evaluation of the effectiveness of this research-based model can guide the feasibility of extending it into an operational model through a specific program.
The possible limitations of the study may include the following:
It was decided to perform the intervention in one clinic, taking another as a control to prevent women from both groups from communicating and transmitting information between them. However, the implementation of the study in two clinics may result in difference baseline characteristics of women in both groups. To overcome this limitation in the data analysis step, the regression methods will be used to adjust the results of the study for possible differences between groups.
Furthermore, the baseline evaluation can affect women in the control group resulting in them seeking counseling regarding the climacteric stage, attending screening programs, and changing their lifestyles.
The request for voluntary collaboration of family doctors and women could result in better doctors and women with healthier lifestyles agreeing to participate. Previous studies have reported that patients with unhealthy lifestyles are usually reluctant to participate. To confirm or disregard this limitation we will apply a short list of questions about the general characteristics and lifestyles to women who do not agree to participate in the study.
Compliance with the leisure time physical activity and healthy diet will be assessed through self-reporting of women unable to verify their actual practice, and will possibly overestimate the effect of the intervention regarding these variables.
Due to budgetary restrictions it is not possible to plan a long-term follow-up (12 months of study) of the IHCM impact.
Due to the financial and organizational feasibility, the study will be tested only in the population covered by IMSS, therefore, we can not say that this strategy would have the same results in women affiliated with other health institutions in Mexico, or women who receive healthcare from the Ministry of Health. However, we expect that the results of this study can be implemented in other institutions, with some necessary adaptations.
The study is sponsored by the Instituto Mexicano del Seguro Social, grant number FIS/IMSS/PROT/G09/740.
- Utian WH: Ovarian function, therapy-oriented definition of menopause and climacteric. Exp Gerontol. 1994, 29: 245-251. 10.1016/0531-5565(94)90003-5.View ArticlePubMedGoogle Scholar
- Menopause and Postmenopause Working Group: Spanish Society of Gynecology and Obstetrics. Spanish Association for the Study of Menopause, Spanish Society of Family and Community Medicine, Iberoamerican Cochrane Centre. Clinical Practice Guideline of Menopause and Postmenopause. 2004, BarcelonaGoogle Scholar
- Pineault R, Daveluy C: La planificación sanitaria. Conceptos, métodos, estratégias. Masson S.A. 1995Google Scholar
- Utian WH: Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review. Health Qual Life Outcomes. 2005, 3: 47-10.1186/1477-7525-3-47.View ArticlePubMedPubMed CentralGoogle Scholar
- Hossain P, Kawar B, El Nahas M: Obesity and diabetes in the developing world--a growing challenge. N Engl J Med. 2007, 356: 213-215. 10.1056/NEJMp068177.View ArticlePubMedGoogle Scholar
- Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J: Global burden of hypertension: analysis of worldwide data. Lancet. 2005, 365: 217-223.View ArticlePubMedGoogle Scholar
- Velasco-Murillo V, Navarrete-Hernández E, Ojeda-Mijares RI, Pozos-Cavanzo JL, Camacho-Rodríguez MA, Cardona-Pérez JA: Experiencia y conocimiento sobre climaterio y menopausia en mujeres de la ciudad de México. Gac Med Mex. 2000, 136: 555-564.PubMedGoogle Scholar
- Doubova SV, Flores-Hernández S, Rodriguez Aguilar L, Pérez-Cuevas R: Quality of care and health related quality of life of climacteric stage women cared for in family medicine clinics. Health Qual Life Outcomes. 2010, 8: 20-10.1186/1477-7525-8-20.View ArticleGoogle Scholar
- López-Correa SM, Carranza Madrigal J: El síndrome metabólico y la depresión en el climaterio y la premenopausia. Med Int Mex. 2010, 26: 307-312.Google Scholar
- Palma O, Shamah Levy T, Franco A, Olaiz G, Méndez-Ramírez I: Metodología. Encuesta Nacional de Salud y Nutrición (ENSANUT-2006). 2006, Cuernavaca: Instituto Nacional de Salud Pública, 19-33.Google Scholar
- Doubova SV, Pérez-Cuevas R, Reyes-Morales H: Self-rated health among climacteric women affiliated to Instituto Mexicano del Seguro Social. Salud Publica Mex. 2008, 50: 390-396.View ArticleGoogle Scholar
- Riera-Espinoza G: Epidemiology of osteoporosis in Latin America 2008. Salud Publica Mex. 2009, 51 (Supl1): S52-S55.View ArticlePubMedGoogle Scholar
- Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. 2010, Lyon, France: International Agency for Research on CancerGoogle Scholar
- Flores-Huerta S, Acosta-Cázares B, Rendón-Macias ME, Klunder-Klunder M, Gutiérrez-Trujillo G: ENCOPREVENIMSS 2004;5. Consumo de alimentos saludables o con riesgo para la salud. Rev Med IMSS. 2006, 44 (Supl1): S63-S78.PubMedGoogle Scholar
- Estudios de la OCDE sobre los sistemas de salud: México. 2005, Organización para la Cooperación y el Desarrollo Económicos. Secretaria de Salud de MéxicoGoogle Scholar
- Shirazi KK, Wallace LM, Niknami S, Hidarnia A, Torkaman G, Gilchrist M, Faghihzadeh S: A home-based, transtheoretical change model designed strength training intervention to increase exercise to prevent osteoporosis in Iranian women aged 40-65 years: a randomized controlled trail. Health Educ Res. 2007, 22: 305-317. 10.1093/her/cyl067.View ArticlePubMedGoogle Scholar
- Manios Y, Moschonis G, Katsaroli I, Grammatikaki E, Tanagra S: Changes in diet quality score, macro- and micronutrients intake following a nutrition education intervention in postmenopausal women. J Hum Nutr Diet. 2007, 20: 126-133. 10.1111/j.1365-277X.2007.00750.x.View ArticlePubMedGoogle Scholar
- Asikainene TM, Syni JH, Pasanen ME, Oja P: Effect of brisk walking in 1 or 2 daily bouts and moderate resistance training on lower-extremity muscle strength, balance, and walking performance in woman who recently went through menopause: a randomized, controlled trial. Phys Ther. 2006, 7: 912-924.Google Scholar
- Teoman N, Ozcan A, Acar B: The effect of exercise on physical fitness and quality of life in postmenopausal women. Maturitas. 2004, 47: 71-77. 10.1016/S0378-5122(03)00241-X.View ArticlePubMedGoogle Scholar
- Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A: Effect of exercise on total and intra-abdominal body fat in postmenopausal women. JAMA. 2003, 289: 323-330. 10.1001/jama.289.3.323.View ArticlePubMedGoogle Scholar
- Hunter M, O'Dea : An evaluation of a health education intervention for mid-aged women: Five-year follow-up of effects upon knowledge, impact of menopause and health. Patient Educ Couns. 1999, 37: 249-255. 10.1016/S0738-3991(98)00143-8.View ArticleGoogle Scholar
- Liao KL, Hunter MS: Preparation for menopause: prospective evaluation of a health education intervention for mid-aged women. Maturitas. 1998, 29: 215-224. 10.1016/S0378-5122(98)00033-4.View ArticlePubMedGoogle Scholar
- Adams J, White M: Why don't stage-based activity promotion interventions work?. Health Educ Res. 2005, 20: 237-243. 10.1093/her/cyg105.View ArticlePubMedGoogle Scholar
- Shapiro DA, Shapiro D: Meta-analysis of comparative therapy outcome studies: a replication and refinement. Psycol Bull. 1982, 92: 581-604. 10.1037/0033-2909.92.3.581.View ArticleGoogle Scholar
- Tremblay A, Sheeran L, Aranda SK: Psychoeducational interventions to alleviate hot flashes: a systematic review. Menopause. 2008, 15: 193-202.PubMedGoogle Scholar
- Larroy García C, Gómez-Calcerrada SG: Intervención cognitivo-conductual en sintomatología menopáusica: efectos a corto plazo. Psicothema. 2009, 21: 255-261.PubMedGoogle Scholar
- Keefer L, Blanchard EB: A behavioral group treatment program for menopausal hot flashes: results of a pilot study. Appl Psychophysiol Biofeedback. 2005, 30: 21-30. 10.1007/s10484-005-2171-1.View ArticlePubMedGoogle Scholar
- Rothert ML, Holmes-Rovner M, Rovner D, Kroll J, Breer L, Talarczyk G, Schmitt N, Padonu G, Wills C: An Educational Intervention as Decision Support for Menopausal Women. Res Nurs Health. 1997, 20: 377-387. 10.1002/(SICI)1098-240X(199710)20:5<377::AID-NUR2>3.0.CO;2-L.View ArticlePubMedGoogle Scholar
- Engel GL: The clinical application of the biopsychosocial model. Am J Psychiatry. 1980, 137: 535-544.View ArticlePubMedGoogle Scholar
- Flint M: Menopause-the global aspect. The modern management of the menopause: A perspective for the 21st century. The International Congress, Symposium, and Seminar Series Proceedings of the Seventh International Congress on the Menopause, Stockholm, Sweden, june 1993. Edited by: Hammar M, Berg G. 1994, New York: Parthenon, 8: 17-22.Google Scholar
- Boon H, Verhoef M, O'Hara D, Findlay B: From parallel practice to integrative health care: a conceptual framework. BMC Health Serv Res. 2004, 4: 15-10.1186/1472-6963-4-15.View ArticlePubMedPubMed CentralGoogle Scholar
- Pinotti JA, Tojal ML, Nisida AC, Pinotti M: Integrated approach to women's health. Int J Gynaecol Obstet. 2000, 70: 191-198. 10.1016/S0020-7292(00)00238-1.View ArticlePubMedGoogle Scholar
- Pérez-Cuevas R, Reyes-Morales H, Doubova SV, Zepeda Arias M, Díaz Rodríguez G, Peña Valdovinos A, Muñoz Hernández O: Atención integral de pacientes diabéticos e hipertensos con participación de enfermeras en medicina familiar. Rev Panam Salud Publica. 2009, 26: 511-517.View ArticlePubMedGoogle Scholar
- Jones PS, Meleis AI: Health is empowerment. ANS Adv Nurs Sci. 1993, 15: 1-14.View ArticlePubMedGoogle Scholar
- Lau DH: Patient empowerment--a patient-centered approach to improve care. Hong Kong Med J. 2002, 8: 372-374.PubMedGoogle Scholar
- Anderson RM, Funnell MM: Patient empowerment: reflections on the challenge of fostering the adoption of a new paradigm. Patient Educ Couns. 2005, 57: 153-157. 10.1016/j.pec.2004.05.008.View ArticlePubMedGoogle Scholar
- Funnell MM, Anderson RM: Empowerment and Self-Management of Diabetes. Clin DIiabetes. 2004, 22: 123-127. 10.2337/diaclin.22.3.123.View ArticleGoogle Scholar
- Williams GC, Minicucci DS, Kouides RW, Levesque CS, Chirkov VI, Ryan RM, Deci EL: Self-determination, smoking, diet and health. Health Educ Res. 2002, 17: 512-521. 10.1093/her/17.5.512.View ArticlePubMedGoogle Scholar
- Anderson RM, Funnell MM, Aikens JE, Krein SL, Fitzgerald JT, Nwankwo R, Tannas CL, Tang TS: Evaluating the Efficacy of an Empowerment-Based Self-Management Consultant Intervention: Results of a Two-Year Randomized Controlled Trial. Ther Patient Educ. 2009, 1: 3-11. 10.1051/tpe/2009002.View ArticlePubMedPubMed CentralGoogle Scholar
- Anderson RM, Funnell MM, Butler PM, Arnold MS, Fitzgerald JT, Feste CC: Patient empowerment. Results of a randomized controlled trial. Diabetes Care. 1995, 18: 943-949. 10.2337/diacare.18.7.943.View ArticlePubMedGoogle Scholar
- Vickery DM, Golaszewski TJ, Wright EC, Kalmer H: The effect of self-care interventions on the use of medical service within a medicare population. Medical Care. 1988, 26: 580-588. 10.1097/00005650-198806000-00006.View ArticlePubMedGoogle Scholar
- Ellis A, Bernard ME: What is rational-emotive therapy?. Handbook of rational-emotive therapy. Edited by: Ellis A, Griegar RM. 1986, New York: Springer, 2: 3-30.Google Scholar
- Girod I, de la Loge C, Keininger D, Hunter MS: Development of a revised version of the Women's Health Questionnaire. Climacteric. 2006, 9: 4-12. 10.1080/13697130500487372.View ArticlePubMedGoogle Scholar
- Anderson RM, Fitzgerald JT, Gruppen LD, Funnell MM, Oh MS: The diabetes empowerment scale-short form (DES-SF). Diabetes Care. 2003, 26: 1641-1643. 10.2337/diacare.26.5.1641.View ArticlePubMedGoogle Scholar
- Reece SM, Harkless G: Testing of the PHS-ES: A measure of perimenopausal health self-efficacy. J Nurs Meas. 2002, 10: 15-26. 10.1891/jnum.10.1.15.52549.View ArticlePubMedGoogle Scholar
- Bellón Saameño JA, Delgado Sánchez A, Luna del Castillo JD, Lardelli Claret P: Validez y fiabilidad del cuestionario de apoyo social funcional Duke-UNC-11. Aten Primaria. 1996, 18: 153-163.PubMedGoogle Scholar
- U.S. Department of Health and Human Services Food and Drug Administration: Guidance for Industry. Estrogen and Estrogen/Progestin Drug Products to Treat Vasomotor Symptoms and Vulvar and Vaginal Atrophy Symptoms -- Recommendations for Clinical Evaluation. 2003, Center for Drug Evaluation and Research (CDER), [http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/WomensHealthResearch/UCM133343.pdf]Google Scholar
- Vázquez AJ, Jiménez R, Vázquez-Morejón R: Escala de autoestima de Rosenberg: fiabilidad y validez en población clínica española. Apuntes de Psicol. 2004, 22: 247-55.Google Scholar
- Rojas-Barahona CA, Zegers PB, Foster MCE: La escala de autoestima de Rosenberg: Validación para Chile en una muestra de jóvenes adultos, adultos y adultos mayores. Rev Méd Chile. 2009, 137: 791-800.View ArticlePubMedGoogle Scholar
- Rosner B: Fundamentals of biostatistics. 2000, Pacific Grove,. Ca: Duxbury Ress, 5Google Scholar
- Girod I, Abetz L, de la Loge C, Fayol-Paget C, Hunter MS: Women's Health Questionnaire user manual. 2004, MAPI Research InstituteGoogle Scholar
- Jack B, Shang Y: Estimating policy and program effects with observational data: the "differences-in-differences" estimator. Practical Assessment, Research & Evaluation. 2003, 8: 24.Google Scholar
- Liang KY, Zeger SL: Longitudinal date analysis using generalized linear models. Biometrika. 1986, 73: 13-22. 10.1093/biomet/73.1.13.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6874/11/6/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.