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Giant uterine artery pseudoaneurysm after a missed miscarriage termination in a cesarean scar pregnancy
© Mou et al.; licensee BioMed Central Ltd. 2014
Received: 30 December 2013
Accepted: 17 July 2014
Published: 29 July 2014
Uterine artery pseudoaneurysms are dangerous and can lead to severe hemorrhage. We report an uncommon cause of a giant pseudoaneurysm in a missed miscarriage in a woman with a cesarean scar pregnancy.
The patient was a 25-year-old Chinese woman with a missed miscarriage in a cesarean scar pregnancy. Curettage was performed under ultrasound monitoring. A uterine artery pseudoaneurysm measuring 71 × 44 × 39 mm was detected the next day by Doppler ultrasonography. While waiting for admittance to an advanced institution to undergo embolization treatment, the pseudoaneurysm ruptured spontaneously. The subsequent severe hemorrhage necessitated hysterectomy.
A delay in diagnosis of uterine artery pseudoaneurysms may result from a long period between the curettage and follow-up examination. Ultrasound and Doppler ultrasonography should be performed repeatedly at short intervals to rule out them, especially in cesarean scar pregnancies. For a giant uterine artery pseudoaneurysm, interventional embolization might be the first treatment choice. If time allows, intra-operative ligation of the feeding vessels should be attempted before any decision to perform a hysterectomy is made. However, hysterectomy remains a possibility when severe bleeding occurs.
Uterine artery pseudoaneurysms are rare complications that can arise after repeated curettage, abortions, cesarean sections, uncomplicated vaginal deliveries or reproductive tract infections. They are dangerous and can lead to severe hemorrhage. The interval from pelvic surgery to the onset of symptoms is typically 1 week to 3 months [1–4]. This delay is supposed to be caused by a gradual increase in the size of the pseudoaneurysm caused by a characteristic pressure increment. The blood flow into the pseudoaneurysm is greater during systole than diastole. This leads to a gradual pressure build up and eventual rupture. It can be treated with hysterectomy with or without hypogastric artery ligation. In recent years, uterine artery embolization has become an accepted treatment method for this condition. The option depends on the patient’s reproductive desires and hemodynamic situation.
A literature search found three case reports of cesarean scar pregnancies complicated with a uterine artery pseudoaneurysm [5–7]. Here, it occurred in a patient with a missed miscarriage during a cesarean scar pregnancy and the lesion was the largest reported to date.
The 25-year-old Chinese female patient had been amenorrheic for 2 months and was referred to the hospital because of painless vaginal bleeding that had lasted for 15 days. Four years ago she had a missed miscarriage at 9 weeks of gestation, which was managed by surgical curettage. Two years prior to presentation she had delivered a baby by elective cesarean. Twenty days before presenting at the hospital she had been diagnosed as 40 days pregnant based on elevated urinary levels of beta human chorionic gonadotropin (β-hCG).
Uterine artery pseudoaneurysms are very dangerous and should be diagnosed as soon as possible. Potential causes include vascular injury following abortion, curettage, and pelvic surgery. Traumatic injury to the vessel wall causes wall incompetence and hemorrhage leading to a pseudoaneurysm. In this case, both two-dimensional and Doppler ultrasound scans were useful in detecting the pseudoaneurysm.
In two-dimensional ultrasonographic images, a pseudoaneurysm manifests as a hypoechoic mass and is thereby not easily differentiated from a hematoma or a true aneurysm. Color Doppler ultrasonography was helpful in this case as it demonstrated turbulent arterial flow with a to-and-fro pattern, connected to a parent artery by a narrow neck in the pseudoaneurysm. Blood flow into the mass during systole and away from the mass during diastole can be explained by the pressure gradient between a distended high-pressure pseudoaneurysm and the low pressure in the artery during diastole . A true aneurysm manifests as a color-coded fusiform dilation of the parent artery and spectral analysis can demonstrate a typical arterial flow pattern. A simple hematoma does not reveal any color signal caused by turbulent blood flow. The wall of a pseudoaneurysm is formed by a peripheral thrombus. In this case, decidual tissue and chorionic tissue were also found in the wall. We diagnosed the pseudoaneurysm by ultrasonography at the day after curettage. Therefore, we think it is necessary for patients to undergo a Doppler ultrasound examination as a required postoperative investigation especially in cases of cesarean scar pregnancy. Repeating these examinations several times over a short time period might allow early diagnosis of a pseudoaneurysm, when it is still small in size.
In this case, the pseudoaneurysm was located in the cesarean scar. The wall of the pseudoaneurysm was very thin and at high risk of rupture, it should have been treated as rapidly as possible. In such cases, endovascular treatment is often the first-line therapy. Embolization can be achieved with coils, stents and injectable liquids [9, 10], and offers the potential of preserving fertility for the patient. However, in the literature, the pseudoaneurysms treated successfully by this method were only 0.6–3.5 cm in diameter .
If time allows, and if embolization is not an option, intra-operative ligation of the pseudoaneurysm feeding vessels should be attempted prior to resorting to hysterectomy, especially in patients with low parity . Ligation of the ascending branch of the uterine artery may successfully stop postabortal hemorrhage in approximately 90% of patients.
Another possible treatment method was direct injection of thrombin into the pseudoaneurysm , but no further experience has been reported in the literature. Thus, we lack knowledge on the scope of possible complications associated with this procedure, such as subsequent arterial thrombosis or allergic responses.
A delay in diagnosis of uterine artery pseudoaneurysms may be caused by a long period between the curettage and follow-up examination. Ultrasound and Doppler ultrasonography are recommended to be performed repeatedly at short intervals to rule out them, especially in cesarean scar pregnancies. For a giant uterine artery pseudoaneurysm, interventional embolization might be the first treatment option when the diagnosis is made. Alternatively, if time allows, intra-operative ligation of the feeding vessels should be performed prior to any decision to resort to hysterectomy. However, hysterectomy remains a possibility when severe bleeding occurs.
Written informed consent was obtained from the patient for publication of this Case Report and the accompanying images. A copy of the written consent is available for review by the Editor of this journal.
This study was supported by the Zhejiang Provincial Natural Science Foundation, P. R. China (No LY13H180008), the National Natural Science Foundation, P. R. China (No 81371571) and the Education Agency of Zhejiang Province, P. R. China (No Y200907825).
- Asai S, Asada H, Furuya M, Ishimoto H, Tanaka M, Yoshimura Y: Pseudoaneurysm of the uterine artery after laparoscopic myomectomy. Fertil Steril. 2009, 91: 929.e1-929.e3.View ArticleGoogle Scholar
- Langer JE, Cope C: Ultrasonographic diagnosis of uterine artery pseudoaneurysm after hysterectomy. J Ultrasound Med. 1999, 18: 711-714.PubMedGoogle Scholar
- Lee WK, Roche CJ, Duddalwar VA, Buckley AR, Morris DC: Pseudoaneurysm of the uterine artery after abdominal hysterectomy: radiologic diagnosis and management. Am J Obstet Gynecol. 2001, 185: 1269-1272. 10.1067/mob.2001.117974.View ArticlePubMedGoogle Scholar
- Higon MA, Domingo S, Bauset C, Martinez J, Pellicer A: Hemorrhage after myomectomy resulting from pseudoaneurysm of the uterine artery. Fertil Steril. 2007, 87: 417.e5-417.e8.View ArticleGoogle Scholar
- Chou MM, Hwang JI, Tseng JJ, Huang YF, Ho ES: Cesarean scar pregnancy: quantitative assessment of uterine neovascularization with 3-dimensional color power Doppler imaging and successful treatment with uterine artery embolization. Am J Obstet Gynecol. 2004, 190: 866-868. 10.1016/j.ajog.2003.11.030.View ArticlePubMedGoogle Scholar
- Rygh AB, Greve OJ, Fjetland L, Berland JM, Eggebo TM: Arteriovenous malformation as a consequence of a scar pregnancy. Acta Obstet Gynecol Scand. 2009, 88: 853-855. 10.1080/00016340902971466.View ArticlePubMedGoogle Scholar
- Akbayir O, Gedikbasi A, Akyol A, Ucar A, Saygi-Ozyurt S, Gulkilik A: Cesarean scar pregnancy: a rare cause of uterine arteriovenous malformation. J Clin Ultrasound. 2011, 39: 534-538. 10.1002/jcu.20848.View ArticlePubMedGoogle Scholar
- Polat P, Suma S, Kantarcý M, Alper F, Levent A: Color Doppler US in the evaluation of uterine vascular abnormalities. Radiographics. 2002, 22: 47-53. 10.1148/radiographics.22.1.g02ja0947.View ArticlePubMedGoogle Scholar
- Sharma N, Ganesh D, Devi L, Srinivasan J, Ranga U: Prompt diagnosis and treatment of uterine arcuate artery pseudoaneurysm: a case report and review of literature. J Clin Diagn Res. 2013, 7: 2303-2306.PubMedPubMed CentralGoogle Scholar
- Jesinger RA, Thoreson AA, Lamba R: Abdominal and pelvic aneurysms and pseudoaneurysms: imaging review with clinical, radiologic, and treatment correlation. Radiographics. 2013, 33: E71-E96. 10.1148/rg.333115036.View ArticlePubMedGoogle Scholar
- Matsubara S, Takahashi Y, Usui R, Nakata M, Kuwata T, Suzuki M: Uterine artery pseudoaneurysm manifesting as postpartum hemorrhage after uneventful second-trimester pregnancy termination. J Obstet Gynaecol Res. 2010, 36: 856-860. 10.1111/j.1447-0756.2010.01190.x.View ArticlePubMedGoogle Scholar
- Mullins JA, O’Leary JA, Askel S: Uterine artery ligation for postabortal hemorrhage. Obstet Gynecol. 1979, 54: 383-384.PubMedGoogle Scholar
- Kovo M, Behar DJ, Friedman V, Malinger G: Pelvic arterial pseudoaneurysm-a rare complication of Cesarean section: diagnosis and novel treatment. Ultrasound Obstet Gynecol. 2007, 30: 783-785. 10.1002/uog.5139.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6874/14/89/prepub
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