Effect of tamoxifen on vaginal blood flow. In control (empty bars) and tamoxifen-infused (solid bars) rats (see Figure 1), changes in vaginal blood flow were measured by laser Doppler flowmetry. Responses to pelvic nerve stimulation at varying frequencies (5–20 Hz) are expressed as the percent change in peak vascular resistance (relative to baseline values) and the area-under-the-curve (AUC). Data are the mean ± SEM and were analyzed by two-way ANOVA. *p < 0.05 versus control group.