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Table 2 Predictors for future HIV-1 infections using Cox proportional hazard models for women that had participated in the MIRA study

From: Biological factors that place women at risk for HIV: evidence from a large-scale clinical trial in Durban

Risk factors

Hazard ratio (95 % confidence interval)

p-value

Pre-existing STIsa

1.05 (0.70, 1.57)

0.81

Genital ulcer/sores

1.72 (1.01, 2.94)

0.04

Pain in urinating

1.01 (0.64, 1.57)

0.96

Pre-existing HSV-2 infection

1.72 (1.18, 2.51)

0.004

Pain during sex

1.22 (0.80, 1.86)

0.34

Genital irritation

1.26 (0.73, 2.20)

0.39

Genital epithelial disruptionb

4.3 (2.20,8.21)

<0.001

Genital signs

1.62 (1.04, 2.54)

0.03

Candidiasis

1.45 (0.70, 2.96)

0.30

Abnormal vaginal discharge

2.22 (1.57, 3.12)

<0.001

Bacterial vaginosis (symptomatic)

1.36 (0.85, 2.19)

0.19

Diagnosed with Treponema pallidum (syphilis)

0.58 (0.21, 1.58) 

0.29

Vaginal bleeding

1.39 (0.86, 2.26)

0.17

Warts

0.75 (0.10, 5.40) 

0.78

  1. aNeisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis
  2. bVaginal, vulva, perineum