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Rare case of complete colon structure in a mature cystic teratoma of the ovary in menopausal woman: a case report
BMC Women's Health volume 16, Article number: 70 (2016)
Mature cystic teratoma (MCT) of the ovary is benign germ cell tumor and shows the highest incidence in women of reproductive age. Histologically, it includes components derived from endoderm, mesoderm, and ectoderm. Although there have been many reports of MCT having small part of the intestinal component, ovarian MCT containing complete colon structure was very rare.
A 54-year-old woman underwent laparoscopic left salpingo-oophorectomy due to an incidentally found ovarian mass. The pathologic diagnosis of the ovary was MCT containing complete colonic structure. The colonic wall exhibited complete structure of the large intestine composed of mucosa, submucosa, proper muscle, subserosa and serosa. It also contained sebaceous gland, sweat glands, fat tissue, and bone. The patient recovered without any complications.
Immunohistochemical staining can be used for differential diagnosis between MCT with colonic wall and mucinous tumor. We report a very rare case of MCT that had complete colon structure with a brief literature review.
Mature cystic teratoma (MCT) of the ovary, as a synonym for the ovarian dermoid cyst, is a benign germ cell tumor. The words “teratoma” and “dermoid” were first described by Leblanc in 1831 . The incidence of MCT is 10–20 % of all ovarian tumors and 70 % of benign ovarian tumors in young women aged under 30 years. MCT shows the highest incidence in reproductive women (age range from 20 to 40 years) [2, 3]. MCT contains components originating from 3 germ cell layers (ectoderm, mesoderm, and endoderm) with different ratios, which include skin, neural components, teeth, cartilage, respiratory epithelium, and intestinal epithelium . About 7–13 % of MCT cases include intestinal epithelium , however, there have been only a few cases of ovarian MCT including complete colon structures [5, 6].
Herein, we report an extremely rare case of MCT that had complete colon structures.
A 54-year-old woman visited our outpatient clinic for pap-smear and routine medical check-up. She had a history of cesarean section and vaginal mesh operation due to urinary incontinence. She had no specific history of medication. We found a left ovarian cyst that had hypoechoic and hyperechoic lesions in the cyst on ultrasonography. The ovary measured 5.0 × 5.6 cm (Fig. 1). The right ovary and uterus showed no abnormal findings. Physical examination exhibited no tenderness or rebound tenderness on the left lower quadrant. The patient had negative cytologic findings on pap-smear. The patient underwent laparoscopic left salpingo-oophorectomy. The left ovarian mass tightly adhered to the omentum (Fig. 2), so we removed the left tube and ovary after adhesiolysis. Macroscopically, the ovarian mass was mainly filled with sebaceous materials, whose cystic wall contained complete colon structure (Fig. 3).
On light microscopy with hematoxylin and eosin staining, the pathologic diagnosis of the ovary was MCT containing complete colonic structures without any sign of malignancy (Fig. 4a). Normal colonic structure was composed of mucosa, submucosa, proper muscle, subserosa and serosa layer (Fig. 4a, b). The magnified view of the muscle layer exhibited well oriented inner circular and outer longitudinal muscle layers and myenterix nerve plexus (Fig. 4c). The ovarian mass also had sebaceous gland, sweat gland, fat tissue, and bone (Fig. 4d). It showed positivity for CK 20 and negativity for CK 7 on immunohistochemistry (Fig. 4f and g). These results supported the MCT containing colonic epithelial structure as normal. The patient recovered very well without complication.
MCT of the ovary can occur in women from adolescents to postmenopausal women. It usually develops unilaterally, but 8–15 % of MCT cases occur bilaterally. MCT is a slowly growing tumor, and the estimated increasing rate is 1.8 cm per year . Furthermore, the long term recurrence rate is 4.7 % after surgery . Therefore, fertility - sparing surgery has been performed on women with MCT in reproductive age .
Approximately 2 % of all MCT cases undergo malignant transformation. Squamous cell carcinoma is the most common type that account for 83 %, and adenocarcinoma, sarcoma, and carcinoid tumors account for the majority of the rest . The intestinal type of MCT is associated with adenocarcinoma developed from MCT. Fishman et al.  documented a rare case of adenocarcinoma arising from gastrointestinal epithelium of MCT. Since then, many authors reported gastrointestinal epithelium associated with MCT [10–12]. As the germline components of MCT were arranged haphazardly, MCT containing well oriented complete intestinal structureis very rare, and only 3 cases have been reported in the literature (Table 1). Fujiwara et al.  reported 2 cases of MCT, one being a benign MCT containing a complete segment of the intestinal wall and the other being adenocarcinoma from MCT with complete colonic structure and bronchial epithelium as well. The prognosis of benign MCT was favorable, and patients were alive at 5 years after surgery without recurrences. Tang et al.  reported 1 case of a patient who was diagnosed with benign MCT containing complete colonic structures.
Immunohistochemical staining can be used for differential diagnosis between MCT with colonic wall and mucinous tumor. They also identified that normal colons are positive for CK20 and negative for CK7 on immunohistochemistry. However, ovarian mucinous cystadenoma shows positivity for CK7 and negativity on CK 20 . In contrast to benign mucinous epithelium, malignant epithelium associated with MCT more frequently shows negativity for CK7 and positivity for CK20, MUC2, and CDX2 . Also, immunohistochemical positivity for CEA, CA19-9, and CK-20 was reported to have a strong relationship with malignant mucinous epithelium .
In our case, we found MCT of the ovary containing complete colonic structure in menopausal woman. Also, there was no evidence of malignant transformation.
In summary, our case provides evidence that benign MCT of the ovary containing complete colonic structure shows positivity for CK 20 and negativity for CK 7 on immunohistochemistry.
Mature cystic teratoma
- H & E:
Hematoxylin and eosin
Total abdominal hysterectomy
Pelvic lymph node dissection
Para-aortic lymph node dissection
No evidence of disease
Kim MJ, Kim NY, Lee DY, Yoon BK, Choi D. Clinical characteristics of ovarian teratoma: age-focused retrospective analysis of 580 cases. Am J Obstet Gynecol. 2011;205(1):32. e1-4.
Alotaibi MO, Navarro OM. Imaging of ovarian teratomas in children: a 9-year review. Can Assoc Radiol J. 2010;61(1):23–8.
Templeman CL, Fallat ME, Lam AM, Perlman SE Hertweck SP, O’Connor DM. Managing mature cystic teratomas of the ovary. Obstet Gynecol Surv. 2000;55(12):738–45.
Caruso PA, Marsh MR, Minkowitz S, Kartan G. An intense clinicpathologic study of 305 teratomas of the ovary. Cancer. 1971;27(2):343–8.
Fujiwara K, Ginzan S, Silverberg SG. Mature cystic teratomas of the ovary with intestinal wall structures harboring intestinal type epithelial neoplasms. Gynecol Oncol. 1995;56:97–101.
Tang P, Soukkary S, Kahn E. Mature cystic teratoma of the ovary associated with complete colonic wall and muconpus cystadenoma. Ann Clni Lab Sci. 2003;33(4):465–70.
Caspi B, Appelman Z, Rabinerson D, Zalel Y, Tulandi T, Shoham Z. The growth pattern of ovarian dermoid cysts: a prospective study in premenopausal and postmenopausal women. Fertil Steril. 1997;68(3):501–5.
Chang CF, Lin CK. A case of recurrent, bilateral ovarian mature teratoma in a young woman. BMC Womens Health. 2014;14:57–60.
Fishman A, Edelstein E, Altaras M, Beyth Y, Bernheim J. Adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary. Gynecol Oncol. 1998;70:418–20.
Levine DA, Villella JA, Poynor EA, Soslow RA. Gastrointestinal adenocarcinoma arising in a mature cystic teratoma of the ovary. Gynecol Oncol. 2004;94(2):597–9.
Min KJ, Jee BC, Lee HS, Kim YB. Intestinal adenocarcinoma arising in a mature cystic teratoma of the ovary: a case report. Pathol Res Pract. 2006;202(7):531–5.
Wheeler L, Weshoff GL, O’Keefe MC, Kong CS, Karam A. Adenocarcinoma with breast/adnexal and upper gastrointestinal differentiation arising in an ovarian mature cystic teratoma: a case report and review of the literature. Int J Gynecol Pathol. 2016;35(1):72–7.
McKenney JK, Soslow RA, Longacre TA. Ovarian mature teratomas with mucinous epithelial neoplasms: morphological heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol. 2008;32(5):645–55.
We are very thankful for the preparation of pathologic slides to Dr. CJ Kim.
This study was not supported by any funding.
Availability of data and materials
We all authors ensure that our datasets are either deposited in publicity available repositories or presented in the main manuscript.
SJL: investigation of the patient, drafting of the manuscript, and corresponding author. DGJ: Investigation of the patient, literature research. DJJ and CJK: review of pathologic diagnosis and confirm the diagnosis. EYK: Drafting of the manuscript and literature research. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written consent was obtained from the patient for publication of this study.
Ethics approval and consent to participate
This study have been performed in accordance with the declaration of Helsinki, was approved by the Institutional Review Board of our hospital (KC16ZISE0037).
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Ki, E.Y., Jang, D.G., Jeong, D.J. et al. Rare case of complete colon structure in a mature cystic teratoma of the ovary in menopausal woman: a case report. BMC Women's Health 16, 70 (2016) doi:10.1186/s12905-016-0349-8
- Germ cell and embryonal