- Research article
- Open Access
- Open Peer Review
This article has Open Peer Review reports available.
The use of complementary and alternative medicine by women experiencing menopausal symptoms in Bologna
- Francesco Cardini†1Email author,
- Grazia Lesi†2,
- Flavia Lombardo†3,
- Corinne van der Sluijs†4 and
- MSCG - Menopause Survey Collaborative Group2
© Cardini et al; licensee BioMed Central Ltd. 2010
Received: 25 June 2009
Accepted: 27 February 2010
Published: 27 February 2010
The present study describes Complementary and Alternative Medicine (CAM) use amongst Italian women transitioning through menopause. Popularity and perceived effectiveness of CAM treatments, use of pharmaceutical medications, characteristics of CAM users, the extent of communication between medical practitioners and women about their use of CAM, and variables associated with CAM use were also investigated.
Women, aged 45-65 years attending Family Planning and Women's Health clinics or Menopause Centres in Bologna were invited to complete a voluntary, anonymous, self administered questionnaire, which was used in a previous study in Sydney. The questionnaire was translated and adapted for use amongst Italian women. Data on general demographic and health characteristics, menopause related symptoms and the use of CAM and pharmaceutical treatments during the previous 12 months were collected.
In total, 1,203 women completed the survey, of which 1,106 were included in the final sample. Of women who had symptoms linked with menopause and/or used remedies to alleviate symptoms, 33.5% reported to have used CAM. Among these, 23.5% had consulted one or more practitioners and 24% had used at least one CAM product.
Approximately nine out of ten respondents reported medical practitioners did not seek information about their use of CAM; while one third of CAM users did not disclose the use of CAM to their physician. Nevertheless, medical practitioners were the most popular source of information. From the multivariate analysis, variables associated with CAM use were: professional employment, time since the last natural menses, use of CAM for conditions other than menopause, and presence of some severe symptoms.
The relatively high prevalence of CAM use by women transitioning through menopause should encourage research initiatives into determining which CAM treatments are the safest and effective. The increasing and likely concomitant use of CAM with HRT and other pharmaceuticals underlines the need for the implementation of a surveillance system to report and monitor possible drug-herb adverse events. The discrepancy between women preferring to seek information about CAM from their medical doctor and the difficulties noted in communication between doctor and patient should encourage educational initiatives on CAM by health-care agencies and institutions.
A significant proportion of women experience symptoms during the peri-menopause and Hormone Replacement Therapy (HRT) is often prescribed to alleviate these symptoms . However, despite the effectiveness of HRT , many women refuse or discontinue treatment because of side effects such as vaginal bleeding, bloating and breast tenderness or due to concerns about an increased risk of cancer or other HRT-linked conditions [3–8]. Therefore, many women are seeking safer alternative therapies to relieve symptoms and improve quality of life [9–19]. A large number of these treatments come under the broad term of Complementary and Alternative Medicine (CAM). This term refers to a wide range of diagnostic and therapeutic practices whose theoretical bases are different from those of the dominant scientific medical model. While in Italy the term generally used is "Non-conventional Medicine", this article uses the term CAM in order to be consistent with terminology used by colleagues and collaborators at CompleMED for present and future work. The terms "CAM products" and "CAM treatments" refer to preparations and treatments prescribed within their respective CAM domain, while the term "CAM practitioners" includes care-givers who may or may not be medical doctors.
In Italy, as in other developed countries, the range of CAM treatments for improving quality of life during the menopausal transition is diverse. Modalities include self-care techniques, treatments that require consultations with qualified professionals and/or the use of herbal or homeopathic products.
Although a number of studies have investigated the use of CAM during the menopausal transition [9–19], only one study was conducted in Italy , which investigated the use of HRT and other treatments for menopausal syndrome amongst a convenience sample of female medical doctors and the wives of doctors.
However, the findings from such a sample do not give a clear representation of the use of CAM. Therefore, the present study, although based on a convenience sample as well, aimed to obtain a more clear insight on the nature of CAM use amongst a larger sample of Italian women transitioning through menopause who were symptomatic or asymptomatic but taking treatments for menopausal related symptoms. We also investigated the popularity and perceived effectiveness of CAM treatments, the use of pharmaceutical medications, the characteristics of CAM users and the extent of communication between medical practitioners and women about their use of CAM.
This project was approved by the Ethics Committee of the Local Health Unit of Bologna and was conducted in collaboration with CompleMED, the Centre for Complementary Medicine, University of Western Sydney. The questionnaire, originally developed, validated and used in a similar study , was translated into Italian (see Additional file 1). The original list of CAM products and CAM practitioners was modified to include modalities most likely to be used by Italian women. The 19 item questionnaire collected data on general demographic and health characteristics, menopause related symptoms and the use of CAM and pharmaceutical treatments during the previous 12 months. "Natural menses" was defined as a menstrual period not brought on by HRT or other medications. The menstrual status was determined from the date of the last natural menses as either having occurred more than 12 months ago, between 2 and 11 months or last month. The severity of symptoms related to menopause was rated according to a scale from 0 (no discomfort) to 6 (extreme discomfort). For clarity in interpreting the results, the severity scores were collapsed to produce three categories (0-1: none; 2-4: mild; 5-6: severe). We defined "CAM users" as women who had consulted at least one CAM practitioner (herbalist, nutritionist, naturopath, acupuncturist, traditional Chinese medical (TCM) doctor, homeopath or other practitioner) and/or used at least one CAM product (soy food or tablets, Cimicifuga racemosa preparations, Angelica sinensis preparations, phytoestrogens extracted from Dioscorea villosa or Trifolium pratense, traditional Chinese herbal formulae, homeopathic pills or other product). Women rated the effectiveness of each CAM treatment they used on a scale from 0 (no effect) to 6 (very effective). As with symptom severity, the perceived effectiveness scores for both practitioners and products were collapsed to produce three categories (0-1: not effective; 2-4: moderately effective; 5-6: very effective). Women were also asked where they had obtained information and advice regarding CAM and whether they had informed their doctor about their use of CAM.
Based on the results from previous studies [9, 10], we calculated a sample size of approximately 1,200 women, which would allow an estimate of CAM use prevalence up to a 25% with a fixed precision of 2.5%.
This sample size was considered large enough to be able to make later comparisons with the sample recruited in Sydney . Women, aged 45-65 years who were literate in Italian and who attended one of seven Family Planning and Women's Health (FP & WH) clinics of the Bologna Local Health Unit or two Menopause Centres (one located at a hospital and the other at a territorial center) were invited to complete the voluntary, anonymous and self administered questionnaire. Over two years the questionnaire was distributed to eligible women by staff, predominately midwives, of participating clinics and centers after information about the purpose of the study was given and informed consent was obtained. Women completed the questionnaire in the waiting room before or immediately after a consultation. Completed questionnaires were placed in a specifically designated closed container stationed in the same room. Women were excluded from the study if they had completed less than 80% of the questionnaire, were not within the designated age range, were asymptomatic but not taking specific treatments for menopausal symptoms or if the use or non-use of CAM was unclear.
Data was entered using the software package EpiInfo 2000. All statistical analyses were conducted by the CNESPS (National Centre of Epidemiology, Health Surveillance and Promotion, Italian National Health Institute, Rome) using the program STATA 8.0 (Stata Corporation, College Station, TX, USA). Data were expressed as percentages, except age which was expressed as the mean and standard deviation (SD). Differences between groups were assessed using the χ2 test for categorical variables and either the Mann-Whitney test (two groups) or the Kruskal-Wallis test (three or more groups) for ordinal variables. In order to determine the characteristics associated to CAM use, we calculated prevalence ratios (PRs) with a multivariate Poisson regression using a robust error variance. All variables in the model were entered on the basis of a previous exploratory univariate analysis. Statistical significance was set at 5% (p < 0.05).
Demographic and general health characteristics
Demographic and health characteristics for the total sample and by therapy used
N = 1106
N = 295
N = 114
CAM & HRT
N = 75
Age (at 2006), mean ± SD
56.0 ± 5.3
55.8 ± 4.9
56.3 ± 5.2
55.6 ± 4.1
Marital status, n ( % )
Education, n ( % )
Occupation, n ( % )
Birth place, n ( % )
Recruitment, n ( % )
FP&WH Clinic **
Last menstruation, n ( % )
≥ 12 months
CAM for other conditions, n (%)
Use of other drugs, n ( % )
Current health, n ( % )
Past health, n ( % )
Menopausal symptoms, n (%≥5):
Severe hot flushes
Use of CAM and HRT for menopausal symptoms
The majority of women (56.2%) reported they had not used any treatment for menopausal complaints during the previous 12 months. Of women who had used remedies to alleviate symptoms, 10.3% had used HRT alone, 26.7% had used CAM exclusively, while 6.8% had used CAM in conjunction with HRT. Overall, 33.5% had used CAM during the twelve months before questionnaire completion. Among CAM users, one in five (20.5%) women had reported using CAM together with HRT, while 15.7% of CAM non users had used HRT (p < 0.05).
Health status and perceived effectiveness of CAM modalities
The majority of women who used any therapy to alleviate menopausal symptoms reported their general health to be good. The current health status reported by women using CAM treatments did not differ when compared to women taking HRT (p = 0.14). The current perceived health of respondents not using any treatment for menopause was significantly better when compared to women who used CAM (p < 0.01). CAM users reported a number of symptoms to be more severe compared to non-users including: sleep disturbance, tension, mood, hot flushes, muscle pain, accelerated heartbeat and sweating.
Communication about CAM with medical practitioners
Approximately nine out of ten respondents reported medical practitioners did not seek information about their use of CAM; CAM users were more often questioned by doctors than non users (19.9% and 7.9% respectively, p <0.001). Thirty one percent of CAM users did not disclose the use of CAM to their physician. It is worth noting, that 83 women (22%) who declared they had never used CAM, were in fact users as they had consulted at least one practitioner and/or used at least one product. Approximately half of the respondents (48.7%) were using prescription medications other than CAM and HRT. This proportion was similar for both CAM and non-CAM users (46.8 and 49.7% respectively).
Sources of information about CAM
Women accessed a wide range of sources to obtain information about CAM. The most popular sources of information were medical practitioners (25%), books and herbalists (15% each), magazines (14%), friends or neighbours (13%) and pharmacists (12%). The most frequently consulted practitioner in the "other" category (completed by 8% of respondents) was the gynaecologist. Television (3%) and the Internet (2%) were the least frequently used sources of information.
Variables associated to CAM use: multivariate analysis
Prevalence Ratios and 95% CI for significant associations with CAM use
Occupation (vs none):
CAM for other reasons (yes vs no)
Last natural menses (vs last month)
≥ 12 months
Symptoms and discomfort (vs none)
One third of our sample, including women aged 45-65 years and attending FP & WH Clinics or Menopause Centers in Bologna, reported to have used at least one CAM modality for menopausal complaints during the 12 months prior to the survey. Previously conducted studies investigating the use of CAM amongst menopausal women reported a wide range in prevalence rates [9–12]. These differences may be due to varying research methodologies and/or the number of modalities included as CAM. Nevertheless, when compared to the outcomes of studies incorporating similar methodologies and large sample sizes, our results indicate that CAM is utilized less frequently in Bologna [9–12, 19]. According to the 2005 Multiscope Survey conducted by the Italian National Institute of Statistics (ISTAT), 20.4% of Italian women aged 45-55 years, and 17% of women aged 55-64 years used at least one CAM treatment during the previous three years . The higher prevalence of use reported by our respondents may be due to different inclusion criteria, as we selected for women with menopausal symptoms. Furthermore, sociological factors may also play a role in the uptake of CAM use in Bologna. The national Multiscope Survey  determined that consumers of CAM tended to be middle-aged, better educated and have higher disposable incomes than non-users. CAM use was also found to be more prevalent in richer north-eastern regions of Italy [21, 22]. Our survey was conducted in an affluent area with adequate medical health care services and facilities, therefore the use of CAM for menopausal complaints in Bologna may be significantly higher than other areas of Italy.
We found that respondents in Bologna were more likely to take CAM products than to see a practitioner, but this difference is less than in other surveys conducted abroad [9, 19]. This could be due to the fact that in Italy CAM products are sold only in pharmacies or herbalist's shops, while in other countries these products are also sold in supermarkets.
Respondents preferred taking soy as food and/or phytoestrogens rather than other CAM products. The addition of soy containing foods to the diet is an easy and inexpensive way to increase phytoestrogen consumption [9, 19]. Therefore, our observation supports the hypothesis that CAM users orient their choices towards simple and less expensive products. Respondents regarded traditional Chinese herbal products, phytoestrogens and Cimicifuga to be the most effective products. Despite individual clinical trial outcomes suggesting that phytoestrogens isolated from soy and other herbs may confer a moderate effect in alleviating menopausal symptoms, the effectiveness of isoflavones and phytoestrogens were not assessed and therefore remains controversial [23, 24]. Contrary to the findings of the Multiscope Italian survey (which refers to the general population), our respondents consulted with herbalists and nutritionists, more often than homeopaths and manipulative therapists such as osteopaths, chiropractors and massage therapists [21, 22]. The findings that manipulative treatments were not commonly utilised for menopausal complaints by respondents contrasts those of the original survey conducted in Sydney .
Our results indicate that, amongst both CAM users and non users, almost one in two respondents used pharmaceutical medications within the past year. Approximately 20% of CAM users had taken HRT during the previous 12 months. However, we were unable to ascertain if pharmaceuticals were used concurrently or sequentially with CAM treatments. Nevertheless, these significantly high usage rates indicate a need to improve our knowledge of and to strengthen our surveillance measures for detecting possible interactions between CAM and pharmaceutical medications [25, 26]. Our results confirm a lack of communication between physicians and patients on the use of CAM , which makes monitoring the use of medications difficult. This lack of communication was bi-directional, as 9 out of 10 respondents indicated that GPs did not discuss their use of CAM, while two out of five CAM users disclosed their use of alternative therapies to their doctor. It was interesting to note the high number of missing (8%) and inconsistent answers (22%) to the question "do you usually tell your medical doctor when using CAM?". The fact that one in five CAM users answered "I have never used CAM" indicates a gap in communication which may be due to either a confusion over the definition of "complementary medicine" or the purposeful concealment of the use of CAM, possibly due to the belief that declaring the use of CAM may negatively interfere with the healing relationship between doctor and patient. This worry is rather common and has been described in previous studies. A national survey conducted in the U.S.  found more than one third of respondents declared they did not disclose the use of CAM to their doctors because "the doctor would not understand" (20%), "would disapprove of or discourage CAM use" (14%) or "might not continue as their provider" (2%). Despite these concerns, participants in our study indicated the medical doctor as the most frequently consulted source of information about CAM. The Internet was one of the least consulted sources, possibly due to the age of respondents, who are more likely to be computer illiterate. Use of the Internet as a source of information may increase in popularity as successive more computer-literate generations reach menopausal age. Since Italian television has dedicated little time to the exploration of CAM, television as a source of information was rated poorly.
The most significant variables associated with CAM use were: having used CAM for other conditions, the presence of severe symptoms, being post menopausal and professionally employed. If a woman had used CAM for other conditions, she was around two times more likely to use CAM for menopausal complaints: this may indicate a level of satisfaction with previous CAM use, warranting its use for menopausal symptoms. Postmenopausal women with severe symptoms were more likely to be users of CAM. The disruption of sleep due to night sweats (more than any other symptom, including hot flushes) may instigate the use of alternative treatments, as women may no longer tolerate symptoms that affect daytime mood and performance. Finally, women who have higher disposable incomes were more likely to use CAM, which is consistent with the findings of previous surveys .
Strengths and limitations
To our knowledge, this is the first comprehensive survey conducted in Italy that explores the use of CAM by symptomatic women or by women who were asymptomatic but taking menopause specific treatments during the menopausal transition. The Italian translation of the questionnaire was validated for face and content by a panel of experts who reviewed and adapted it to the Italian context; it was not validated for repeatability and reliability, given that this had already been done in Australia for the original questionnaire (19). We acknowledge that some limitations of our study make the extrapolation of our results to the general population difficult. The use of convenience sampling of women from a number of health clinics may have over inflated the use of CAM and the reporting of menopausal symptoms. Furthermore, the voluntary self administration of the questionnaire may have selected for respondents who were more interested in CAM thereby overestimating the true prevalence of CAM use. Despite these limitations, we believe our study is valuable in highlighting the popularity of CAM use by symptomatic menopausal women. Strengths of the survey included the large sample size of women recruited throughout the Bologna region, and that we explored the use and perceived effectiveness of both CAM practitioners and products.
The results of this survey highlight a number of issues relating to the use of CAM during the menopausal transition for women in Bologna. The increasing and likely concomitant use of CAM with HRT and other pharmaceuticals may necessitate a need for the implementation of a surveillance system to report and monitor possible drug-herb adverse events.
The discrepancy between women preferring to seek information about CAM from their medical doctor and the difficulties noted in communication between doctor and patient should encourage educational initiatives on CAM by health-care agencies and institutions. Patients should be informed about the risks and benefits of CAM, while health care professionals (particularly primary care practitioners) should be encouraged to communicate effectively with patients about their use of CAM and pharmaceuticals, and clearly record all medications consumed, signaling any possible adverse events or interactions.
The high prevalence of CAM use by women transitioning through menopause should encourage research initiatives into determining which CAM treatments are the safest and effective, giving priority to treatments identified by the literature as the most promising and the most popular; however keeping in mind that popular treatments may not always equate to the most effective.
This survey was proposed and executed by the Consultori Operating Unit, Primary Care Department, AUSL Bologna (Director, at study launch: Dr. Clede Maria Garavini) and funded in the framework of the Non Conventional Medicine Experimental Programme 2006-2007 of the Region Emilia Romagna.
The authors wish to thank Dr. Roberto Raschetti (CNESPS - ISS) for his valuable recommendations regarding the statistical analyses and Dr. Bruno Caffari (CNEPS- ISS) for data processing.
The MSCG (Menopause Survey Collaborative Group - Bologna Local Health Unit) includes: Clede Maria Garavini (Director); Marilena Manfredi, Leonarda Rinaldi, Agnese Ricci, Maria Anita Cutini, Valentina Gualandi, Simonetta Salerno, Antoinette Del Serto, Ida Ceroni, Beatrice Galletti, Elena Macrì, Daniela Pasquini, Maria Siotto, Mariagrazia Opessi, Patrizia Stefanelli, Patrizia Santini, Michela Zuffrano, Marisa.Tonelli, Brunella Fava, Giuseppina Bernabei, Carla Dazzani (Midwives); Giovanni Fattorini, Liviana Gammi, Francesca Ananias, Benedetta Bonavita, Patrizia Masi, Lia Teglio, Maurizio Selvetti, Roberta Consort, Filiberto Ungaro, Massimo Toscano, Valeria Pluchinotta, Clara Mazzanti, Sergio Tirelli, Pasquale Create, Paola Coppola, Emilia Sganga, Daniela Nascetti, Guido Fuschini (MDs); Luca Zucchelli (data input manager).
- Guthrie JR, Dennerstein L, Hopper JL, Burger HG: Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women. Obstet Gynecol. 1996, 88: 437-442. 10.1016/0029-7844(96)00196-2.View ArticlePubMedGoogle Scholar
- MacLennan A, Lester S, Moore V: Oral estrogen replacement therapy versus placebo for hot flushes: a systematic review. Climacteric. 2001, 4: 58-74.View ArticlePubMedGoogle Scholar
- Ettinger B, Pressman A, Silver P: Effect of age on reasons for initiation and discontinuation of hormone replacement therapy. Menopause. 1999, 6: 282-289. 10.1097/00042192-199906010-00017.View ArticlePubMedGoogle Scholar
- Regan MM, Emond SK, Attardo MJ, Parker RA, Greenspan SL: Why do older women discontinue hormone replacement therapy?. J Womens Health Gend Based Med. 2001, 10: 343-350. 10.1089/152460901750269661.View ArticlePubMedGoogle Scholar
- Million Women Study Collaborators: Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet. 2003, 362: 419-427. 10.1016/S0140-6736(03)14065-2.View ArticleGoogle Scholar
- Hulley S, Furberg C, Barrett-Connor E, Cauley J, Grady D, Haskell W, Knopp R, Lowery M, Satterfield S, Schrott H, Vittinghoff E, Hunninghake D, HERS REsearch Group: Noncardiovascular disease outcomes during 6.8 years of hormone therapy: heart and estrogen/progestin replacement study follow-up (HERS II). JAMA. 2002, 288: 58-66. 10.1001/jama.288.1.58.View ArticlePubMedGoogle Scholar
- Writing Group for the Women's Health Initiative Investigators: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002, 288: 321-333. 10.1001/jama.288.3.321.View ArticleGoogle Scholar
- Ettinger B, Grady D, Tosteson ANA, Pressman A, Macer JL: Effect of the Women's Health Initiative on women's decisions to discontinue postmenopausal hormone therapy. Obstet Gynecol. 2003, 102: 1225-1232. 10.1016/j.obstetgynecol.2003.08.007.PubMedGoogle Scholar
- Newton KM, Buist DSM, Keenan NL, Anderson LA, La Croix AZ: Use of alternative therapies for menopause symptoms: results of a population-based study. Obstet Gynecol. 2002, 100: 18-25. 10.1016/S0029-7844(02)02005-7.PubMedGoogle Scholar
- Mantyranta T, Hemminki E, Kangas I, Topo P, Uutela A: Alternative drug use for the climacteric in Finland. Maturitas. 1997, 27: 5-11. 10.1016/S0378-5122(97)01106-7.View ArticlePubMedGoogle Scholar
- Keenan NL, Mark S, Fugh-Berman A, Browne D, Kaczmarczyk J, Hunter C: Severity of menopausal symptoms and use of both conventional and complementary/alternative therapies. Menopause. 2003, 10: 507-515. 10.1097/01.GME.0000064865.58809.3E.View ArticlePubMedGoogle Scholar
- Bair YA, Gold EB, Greendale GA, Sternfeld B, Adler SR, Azari R, Harkey M: Ethnic differences in use of complementary and alternative medicine at midlife: longitudinal results from SWAN participants. Am J Public Health. 2002, 92: 1832-1840. 10.2105/AJPH.92.11.1832.View ArticlePubMedPubMed CentralGoogle Scholar
- Gollschewski S, Anderson D, Skerman H, Lyons-Wall P: The use of complementary and alternative medications by menopausal women in South East Queensland. Womens Health Issues. 2004, 14: 165-171.View ArticlePubMedGoogle Scholar
- Lloyd P, Lupton D, Wiesner D, Hasleton S: Choosing alternative therapy: an exploratory study of sociodemographic characteristics and motives of patients resident in Sydney. Australian Journal of Public Health. 1993, 17: 135-144.View ArticlePubMedGoogle Scholar
- Seidl MM, Stewart DE: Alternative treatments for menopausal symptoms: qualitative study of women's experiences. Canadian Family Physician. 1998, 44: 1271-1276.PubMedPubMed CentralGoogle Scholar
- Factor-Litvak P, Cushman LF, Kronenberg F, Wade C, Kalmuss D: Use of complementary and alternative medicine among women in New York City: A pilot study. The Journal of Alternative and Complementary Medicine. 2001, 7: 658-666. 10.1089/10755530152755216.View ArticleGoogle Scholar
- Vashisht A, Domoney CL, Cronje W, Studd JWW: Prevalence of and satisfaction with complementary therapies and hormone replacement therapy in a specialist menopause clinic. Climacteric. 2001, 4: 250-256.View ArticlePubMedGoogle Scholar
- Cherrington A, Lewis CE, McCreath HE, Herman CJ, Richter DL, Bryrd T: Association of complementary and alternative medicine use, demographic factors, and perimenopausal symptoms in a multiethnic sample of women: the ENDOW study. Family and Community Health. 2003, 26: 74-84.View ArticlePubMedGoogle Scholar
- Sluijs van der C, Bensoussan A, Liyanage L, Shah S: Women's health during mid-life survey: the use of complementary and alternative medicine by symptomatic women transitioning through menopause in Sydney. Menopause. 2007, 14: 397-403. 10.1097/01.gme.0000236937.36078.f4.View ArticlePubMedGoogle Scholar
- Biglia N, Cozzarella M, Ponzone R, Marenco D, Maggiorotto F, Fuso L, Sismondi P: Personal use of HRT by postmenopausal women doctors and doctors' wives in the north of Italy. Gynecol Endocrinol. 2004, 18: 165-74. 10.1080/09513590310001653026.View ArticlePubMedGoogle Scholar
- Istituto Nazionale di Statistica: Le terapie non convenzionali in Italia. [http://www.istat.it/salastampa/comunicati/non_calendario/20070821_00/]
- Menniti-Ippolito F, Gargiulo L, Bologna E, Forcella E, Raschetti R: Use of unconventional medicine in Italy: a nation-wide survey. Eur J Clin Pharmacol. 2002, 58: 61-4. 10.1007/s00228-002-0435-8.View ArticlePubMedGoogle Scholar
- Howes LG, Howes JB, Knight DC: Isoflavone therapy for menopausal flushes; a systematic review and meta-analysis. Maturitas. 2006, 55: 203-211. 10.1016/j.maturitas.2006.03.008.View ArticlePubMedGoogle Scholar
- Lethaby AE, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J: Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2007, 17 (4): CD001395.Google Scholar
- Page RL, Lawrence JD: Potentiation of warfarin by dong quai. Pharmacotherapy. 1999, 19: 870-876. 10.1592/phco.19.10.870.31558.View ArticlePubMedGoogle Scholar
- Cambria-Kiely JA: Effect of soy milk on warfarin efficacy. Annals of Pharmacotherapy. 2002, 36: 1893-1896. 10.1345/aph.1C160.View ArticlePubMedGoogle Scholar
- Cockayne NL, Duguid M, Shenfield GM: Health professionals rarely record history of complementary and alternative medicines. Br J Clin Pharmacol. 2004, 59: 254-258. 10.1111/j.1365-2125.2004.02328.x.View ArticleGoogle Scholar
- Eisenberg DM, Kessler RC, Van Rompay MI, Kaptchuk TJ, Wilkey SA, Appel S, Davis RB: Perceptions about complementary therapies relative to conventional therapies among adults who use both: results from a national survey. Ann Intern Med. 2001, 135: 344-351.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6874/10/7/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.